Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SLE

Structure of Reductive Aminase from Neosartorya fumigata in complex with NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0031491	molecular_function	nucleosome binding
A	0050661	molecular_function	NADP binding
A	0140673	biological_process	transcription elongation-coupled chromatin remodeling
B	0000166	molecular_function	nucleotide binding
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0031491	molecular_function	nucleosome binding
B	0050661	molecular_function	NADP binding
B	0140673	biological_process	transcription elongation-coupled chromatin remodeling
C	0000166	molecular_function	nucleotide binding
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0031491	molecular_function	nucleosome binding
C	0050661	molecular_function	NADP binding
C	0140673	biological_process	transcription elongation-coupled chromatin remodeling
D	0000166	molecular_function	nucleotide binding
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0031491	molecular_function	nucleosome binding
D	0050661	molecular_function	NADP binding
D	0140673	biological_process	transcription elongation-coupled chromatin remodeling
E	0000166	molecular_function	nucleotide binding
E	0000785	cellular_component	chromatin
E	0003677	molecular_function	DNA binding
E	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
E	0031491	molecular_function	nucleosome binding
E	0050661	molecular_function	NADP binding
E	0140673	biological_process	transcription elongation-coupled chromatin remodeling
F	0000166	molecular_function	nucleotide binding
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
F	0016491	molecular_function	oxidoreductase activity
F	0031491	molecular_function	nucleosome binding
F	0050661	molecular_function	NADP binding
F	0140673	biological_process	transcription elongation-coupled chromatin remodeling
G	0000166	molecular_function	nucleotide binding
G	0000785	cellular_component	chromatin
G	0003677	molecular_function	DNA binding
G	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
G	0016491	molecular_function	oxidoreductase activity
G	0031491	molecular_function	nucleosome binding
G	0050661	molecular_function	NADP binding
G	0140673	biological_process	transcription elongation-coupled chromatin remodeling
H	0000166	molecular_function	nucleotide binding
H	0000785	cellular_component	chromatin
H	0003677	molecular_function	DNA binding
H	0008442	molecular_function	3-hydroxyisobutyrate dehydrogenase activity
H	0016491	molecular_function	oxidoreductase activity
H	0031491	molecular_function	nucleosome binding
H	0050661	molecular_function	NADP binding
H	0140673	biological_process	transcription elongation-coupled chromatin remodeling

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue NAP A 1000

Chain	Residue
A	GLY8
A	LEU65
A	LEU66
A	ALA70
A	THR74
A	THR91
A	ASN92
A	ILE117
A	ALA119
A	PRO121
A	HOH1103
A	LEU9
A	HOH1104
B	SER229
B	ASN230
B	MET233
C	ALA267
A	GLY10
A	ALA11
A	MET12
A	ASN31
A	ARG32
A	SER33
A	CYS64

site_id	AC2
Number of Residues	16
Details	binding site for residue NAP B 301

Chain	Residue
A	SER229
A	ASN230
A	MET233
B	LEU9
B	GLY10
B	ALA11
B	MET12
B	ARG32
B	SER33
B	LEU65
B	LEU66
B	ASN92
B	ILE117
B	ALA119
B	THR120
B	PRO121

site_id	AC3
Number of Residues	19
Details	binding site for residue NAP C 301

Chain	Residue
C	GLY8
C	LEU9
C	GLY10
C	ALA11
C	MET12
C	ASN31
C	ARG32
C	SER33
C	CYS64
C	LEU65
C	LEU66
C	ALA70
C	THR91
C	ASN92
C	ILE117
C	ALA119
H	SER229
H	ASN230
H	MET233

site_id	AC4
Number of Residues	22
Details	binding site for residue NAP D 301

Chain	Residue
D	LEU9
D	GLY10
D	ALA11
D	MET12
D	ASN31
D	ARG32
D	SER33
D	ALA37
D	CYS64
D	LEU65
D	LEU66
D	ALA70
D	THR74
D	THR91
D	ASN92
D	ILE117
D	ALA119
D	HOH408
E	SER229
E	ASN230
E	MET233
G	ALA267

site_id	AC5
Number of Residues	17
Details	binding site for residue NAP E 301

Chain	Residue
D	SER229
D	ASN230
D	MET233
E	GLY8
E	LEU9
E	GLY10
E	ALA11
E	MET12
E	ARG32
E	CYS64
E	LEU65
E	LEU66
E	ALA70
E	ASN92
E	ILE117
E	ALA119
E	HOH405

site_id	AC6
Number of Residues	21
Details	binding site for residue NAP F 301

Chain	Residue
F	GLY8
F	LEU9
F	GLY10
F	ALA11
F	MET12
F	ASN31
F	ARG32
F	SER33
F	CYS64
F	LEU65
F	LEU66
F	ALA70
F	THR74
F	ASN92
F	ILE117
F	ALA119
F	PRO121
G	SER229
G	ASN230
G	MET233
E	ALA267

site_id	AC7
Number of Residues	19
Details	binding site for residue NAP G 301

Chain	Residue
F	SER229
F	ASN230
F	MET233
G	LEU9
G	GLY10
G	ALA11
G	MET12
G	ASN31
G	SER33
G	CYS64
G	LEU65
G	LEU66
G	THR91
G	ASN92
G	ILE117
G	ALA119
G	PRO121
G	HOH401
G	HOH408

site_id	AC8
Number of Residues	20
Details	binding site for residue NAP H 1001

Chain	Residue
B	ALA267
C	SER229
C	ASN230
C	MET233
H	LEU9
H	GLY10
H	ALA11
H	MET12
H	ASN31
H	ARG32
H	SER33
H	CYS64
H	LEU65
H	LEU66
H	ALA70
H	THR74
H	THR91
H	ASN92
H	ILE117
H	ALA119

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)