6SKS

Crystal structure of bovine carbonic anhydrase II in complex with a benzenesulfonamide-based ligand (SH1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0015670	biological_process	carbon dioxide transport
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0018820	molecular_function	cyanamide hydratase activity
A	0038166	biological_process	angiotensin-activated signaling pathway
A	0044070	biological_process	regulation of monoatomic anion transport
A	0045177	cellular_component	apical part of cell
A	0046872	molecular_function	metal ion binding
A	0051453	biological_process	regulation of intracellular pH
A	2001150	biological_process	positive regulation of dipeptide transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CU A 301

Chain	Residue
A	HIS2
A	HIS9
A	HIS14
A	ASP18
A	HOH571

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CU A 302

Chain	Residue
A	ASP150
A	E68308
A	HOH538
A	HOH548

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CU A 303

Chain	Residue
A	HIS3
A	TRP4
A	HIS63
A	HOH401
A	HOH575

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CU A 304

Chain	Residue
A	HIS3
A	HIS63
A	HOH553

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 305

Chain	Residue
A	HIS93
A	HIS95
A	HIS118
A	E68308

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL A 306

Chain	Residue
A	TYR6
A	TRP243
A	HOH433

---

site_id	AC7
Number of Residues	10
Details	binding site for residue GOL A 307

Chain	Residue
A	ASN61
A	HIS63
A	SER64
A	ASN66
A	GLN91
A	HIS93
A	E68308
A	HOH424
A	HOH503
A	HOH506

---

site_id	AC8
Number of Residues	18
Details	binding site for residue E68 A 308

Chain	Residue
A	ASP71
A	VAL90
A	GLN91
A	HIS93
A	HIS95
A	HIS118
A	VAL120
A	PHE129
A	ASP150
A	LEU196
A	THR197
A	THR198
A	TRP207
A	CU302
A	ZN305
A	GOL307
A	HOH410
A	HOH549

---

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdrkkYaaELHLV

Chain	Residue	Details
A	SER104-VAL120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	256
Details	Domain: {"description":"Alpha-carbonic anhydrase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01134","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15039588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Site: {"description":"Fine-tunes the proton-transfer properties of H-64","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P27139","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---