6SKB

Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK3496783A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue LH5 A 301

Chain	Residue
A	LEU41
A	VAL213
A	TRP215
A	GLY216
A	ASP217
A	TYR218
A	CYS220
A	GLY226
A	RH5302
A	HOH459
A	HOH471
A	HIS57
A	ASP189
A	SER190
A	CYS191
A	GLN192
A	GLY193
A	ASP194
A	SER195

---

site_id	AC2
Number of Residues	15
Details	binding site for residue RH5 A 302

Chain	Residue
A	LEU41
A	HIS57
A	ASP189
A	SER190
A	CYS191
A	GLN192
A	GLY193
A	ASP194
A	SER195
A	GLY216
A	ASP217
A	TYR218
A	CYS220
A	LH5301
A	HOH471

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL C 303

Chain	Residue
A	PRO92
A	ASP93
C	TYR34
C	PHE66
C	LYS70
C	LEU73
C	HOH449

---

site_id	AC4
Number of Residues	20
Details	binding site for residue LH5 C 302

Chain	Residue
A	GLY38
C	LEU41
C	HIS57
C	ASP189
C	SER190
C	CYS191
C	GLN192
C	GLY193
C	ASP194
C	SER195
C	VAL213
C	TRP215
C	GLY216
C	ASP217
C	TYR218
C	CYS220
C	RH5301
C	HOH459
C	HOH487
C	HOH505

---

site_id	AC5
Number of Residues	19
Details	binding site for Di-peptide LH5 B 301 and SER B 195

Chain	Residue
B	LEU41
B	CYS42
B	GLY43
B	HIS57
B	ASP189
B	SER190
B	CYS191
B	GLY193
B	ASP194
B	GLY196
B	GLY197
B	VAL213
B	TRP215
B	GLY216
B	ASP217
B	TYR218
B	CYS220
B	RH5302
B	HOH422

---

site_id	AC6
Number of Residues	18
Details	binding site for Di-peptide RH5 B 302 and SER B 195

Chain	Residue
B	LEU41
B	CYS42
B	GLY43
B	HIS57
B	ASP189
B	SER190
B	CYS191
B	GLY193
B	ASP194
B	GLY196
B	GLY197
B	VAL213
B	TRP215
B	GLY216
B	ASP217
B	TYR218
B	CYS220
B	LH5301

---

site_id	AC7
Number of Residues	21
Details	binding site for Di-peptide RH5 C 301 and SER C 195

Chain	Residue
C	LEU41
C	CYS42
C	GLY43
C	HIS57
C	CYS58
C	ASP189
C	SER190
C	CYS191
C	GLN192
C	GLY193
C	ASP194
C	GLY196
C	GLY197
C	VAL213
C	GLY216
C	ASP217
C	TYR218
C	CYS220
C	LH5302
C	HOH505
A	GLY38

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	660
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12016211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Cleavage; by autolysis"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---