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6SIU

Crystal structure of IbpAFic2 covalently tethered to Cdc42

Functional Information from GO Data
ChainGOidnamespacecontents
C0000139cellular_componentGolgi membrane
C0000322cellular_componentstorage vacuole
C0002040biological_processsprouting angiogenesis
C0003015biological_processheart process
C0003161biological_processcardiac conduction system development
C0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005925cellular_componentfocal adhesion
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0007015biological_processactin filament organization
C0007030biological_processGolgi organization
C0007088biological_processregulation of mitotic nuclear division
C0007097biological_processnuclear migration
C0007163biological_processestablishment or maintenance of cell polarity
C0007229biological_processintegrin-mediated signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007399biological_processnervous system development
C0008104biological_processprotein localization
C0009653biological_processanatomical structure morphogenesis
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0017119cellular_componentGolgi transport complex
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030036biological_processactin cytoskeleton organization
C0030141cellular_componentsecretory granule
C0030154biological_processcell differentiation
C0030175cellular_componentfilopodium
C0030225biological_processmacrophage differentiation
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030742molecular_functionGTP-dependent protein binding
C0031252cellular_componentcell leading edge
C0031256cellular_componentleading edge membrane
C0031274biological_processpositive regulation of pseudopodium assembly
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
C0031996molecular_functionthioesterase binding
C0032427molecular_functionGBD domain binding
C0032467biological_processpositive regulation of cytokinesis
C0032488biological_processCdc42 protein signal transduction
C0032956biological_processregulation of actin cytoskeleton organization
C0032991cellular_componentprotein-containing complex
C0034191molecular_functionapolipoprotein A-I receptor binding
C0034329biological_processcell junction assembly
C0034332biological_processadherens junction organization
C0035050biological_processembryonic heart tube development
C0035088biological_processestablishment or maintenance of apical/basal cell polarity
C0036336biological_processdendritic cell migration
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0038189biological_processneuropilin signaling pathway
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043410biological_processpositive regulation of MAPK cascade
C0043525biological_processpositive regulation of neuron apoptotic process
C0044788biological_processmodulation by host of viral process
C0045177cellular_componentapical part of cell
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045335cellular_componentphagocytic vesicle
C0045740biological_processpositive regulation of DNA replication
C0046330biological_processpositive regulation of JNK cascade
C0046847biological_processfilopodium assembly
C0048549biological_processpositive regulation of pinocytosis
C0048664biological_processneuron fate determination
C0051130biological_processpositive regulation of cellular component organization
C0051233cellular_componentspindle midzone
C0051489biological_processregulation of filopodium assembly
C0051491biological_processpositive regulation of filopodium assembly
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051647biological_processnucleus localization
C0051649biological_processestablishment of localization in cell
C0051683biological_processestablishment of Golgi localization
C0051835biological_processpositive regulation of synapse structural plasticity
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051988biological_processregulation of attachment of spindle microtubules to kinetochore
C0060047biological_processheart contraction
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
C0060661biological_processsubmandibular salivary gland formation
C0060997biological_processdendritic spine morphogenesis
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0071346biological_processcellular response to type II interferon
C0071944cellular_componentcell periphery
C0072384biological_processorganelle transport along microtubule
C0072686cellular_componentmitotic spindle
C0086101biological_processendothelin receptor signaling pathway involved in heart process
C0090135biological_processactin filament branching
C0090316biological_processpositive regulation of intracellular protein transport
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099159biological_processregulation of modification of postsynaptic structure
C0099175biological_processregulation of postsynapse organization
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D0000139cellular_componentGolgi membrane
D0000322cellular_componentstorage vacuole
D0002040biological_processsprouting angiogenesis
D0003015biological_processheart process
D0003161biological_processcardiac conduction system development
D0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005925cellular_componentfocal adhesion
D0006897biological_processendocytosis
D0006911biological_processphagocytosis, engulfment
D0007015biological_processactin filament organization
D0007030biological_processGolgi organization
D0007088biological_processregulation of mitotic nuclear division
D0007097biological_processnuclear migration
D0007163biological_processestablishment or maintenance of cell polarity
D0007229biological_processintegrin-mediated signaling pathway
D0007264biological_processsmall GTPase-mediated signal transduction
D0007399biological_processnervous system development
D0008104biological_processprotein localization
D0009653biological_processanatomical structure morphogenesis
D0010591biological_processregulation of lamellipodium assembly
D0010592biological_processpositive regulation of lamellipodium assembly
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0017119cellular_componentGolgi transport complex
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030036biological_processactin cytoskeleton organization
D0030141cellular_componentsecretory granule
D0030154biological_processcell differentiation
D0030175cellular_componentfilopodium
D0030225biological_processmacrophage differentiation
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030742molecular_functionGTP-dependent protein binding
D0031252cellular_componentcell leading edge
D0031256cellular_componentleading edge membrane
D0031274biological_processpositive regulation of pseudopodium assembly
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
D0031996molecular_functionthioesterase binding
D0032427molecular_functionGBD domain binding
D0032467biological_processpositive regulation of cytokinesis
D0032488biological_processCdc42 protein signal transduction
D0032956biological_processregulation of actin cytoskeleton organization
D0032991cellular_componentprotein-containing complex
D0034191molecular_functionapolipoprotein A-I receptor binding
D0034329biological_processcell junction assembly
D0034332biological_processadherens junction organization
D0035050biological_processembryonic heart tube development
D0035088biological_processestablishment or maintenance of apical/basal cell polarity
D0036336biological_processdendritic cell migration
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0038189biological_processneuropilin signaling pathway
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043410biological_processpositive regulation of MAPK cascade
D0043525biological_processpositive regulation of neuron apoptotic process
D0044788biological_processmodulation by host of viral process
D0045177cellular_componentapical part of cell
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0045335cellular_componentphagocytic vesicle
D0045740biological_processpositive regulation of DNA replication
D0046330biological_processpositive regulation of JNK cascade
D0046847biological_processfilopodium assembly
D0048549biological_processpositive regulation of pinocytosis
D0048664biological_processneuron fate determination
D0051130biological_processpositive regulation of cellular component organization
D0051233cellular_componentspindle midzone
D0051489biological_processregulation of filopodium assembly
D0051491biological_processpositive regulation of filopodium assembly
D0051492biological_processregulation of stress fiber assembly
D0051496biological_processpositive regulation of stress fiber assembly
D0051647biological_processnucleus localization
D0051649biological_processestablishment of localization in cell
D0051683biological_processestablishment of Golgi localization
D0051835biological_processpositive regulation of synapse structural plasticity
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051988biological_processregulation of attachment of spindle microtubules to kinetochore
D0060047biological_processheart contraction
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
D0060661biological_processsubmandibular salivary gland formation
D0060997biological_processdendritic spine morphogenesis
D0061630molecular_functionubiquitin protein ligase activity
D0070062cellular_componentextracellular exosome
D0071346biological_processcellular response to type II interferon
D0071944cellular_componentcell periphery
D0072384biological_processorganelle transport along microtubule
D0072686cellular_componentmitotic spindle
D0086101biological_processendothelin receptor signaling pathway involved in heart process
D0090135biological_processactin filament branching
D0090316biological_processpositive regulation of intracellular protein transport
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099159biological_processregulation of modification of postsynaptic structure
D0099175biological_processregulation of postsynapse organization
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue SO4 A 3801
ChainResidue
AARG3660
ALEU3661
ALYS3665
BLYS3532

site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 3802
ChainResidue
AGLU3537
AHOH3918
AHOH3923
DGLN74

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 3803
ChainResidue
AARG3725
DLJN203
ASER3611

site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 A 3804
ChainResidue
ATHR3641
AVAL3642
AGLN3643

site_idAC5
Number of Residues5
Detailsbinding site for residue SO4 B 3801
ChainResidue
ALYS3532
BARG3660
BLEU3661
BLYS3665
BHOH3903

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 B 3802
ChainResidue
BPRO3536
BGLU3537
CGLN74

site_idAC7
Number of Residues4
Detailsbinding site for residue SO4 B 3803
ChainResidue
BTHR3610
BSER3611
BARG3725
BHOH3901

site_idAC8
Number of Residues3
Detailsbinding site for residue SO4 B 3804
ChainResidue
BTHR3641
BVAL3642
BGLN3643

site_idAC9
Number of Residues18
Detailsbinding site for residue GDP C 201
ChainResidue
BGLU3671
CASP11
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CPHE28
CVAL33
CGLN116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CHOH302
CHOH303

site_idAD1
Number of Residues5
Detailsbinding site for residue GOL C 202
ChainResidue
BSER3534
CVAL36
CTHR58
CALA59
CHOH317

site_idAD2
Number of Residues5
Detailsbinding site for residue SO4 C 204
ChainResidue
BSER3761
CSER86
CPRO87
CSER88
CGLN134

site_idAD3
Number of Residues19
Detailsbinding site for residue GDP D 201
ChainResidue
AASN3672
DALA13
DVAL14
DGLY15
DLYS16
DTHR17
DCYS18
DPHE28
DVAL33
DGLN116
DASP118
DSER158
DALA159
DLEU160
DHOH308
DHOH309
DHOH313
DHOH314
DHOH315

site_idAD4
Number of Residues2
Detailsbinding site for residue GOL D 202
ChainResidue
ASER3534
DALA59

site_idAD5
Number of Residues5
Detailsbinding site for residue SO4 D 204
ChainResidue
ASER3761
DSER86
DPRO87
DSER88
DGLN134

site_idAD6
Number of Residues18
Detailsbinding site for Di-peptide LJN C 203 and TYR C 32
ChainResidue
CHOH304
CHOH308
BTHR3669
BLYS3670
BALA3673
BTYR3710
BILE3714
BHIS3717
BGLU3721
BASN3723
BGLY3724
BARG3728
BGLU3751
BILE3754
BCYS3755
BHOH3901
CGLU31
CVAL33

site_idAD7
Number of Residues18
Detailsbinding site for Di-peptide LJN D 203 and TYR D 32
ChainResidue
ATHR3669
ALYS3670
AALA3673
APHE3675
ATYR3710
AILE3714
AHIS3717
AGLY3722
AASN3723
AGLY3724
AARG3728
AGLU3751
ACYS3755
ASO43803
DGLU31
DVAL33
DHOH301
DHOH307

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
CGLY10
CTHR115
DGLY10
DTHR115
BLYS3670
BGLY3722
BARG3728
BGLN3757

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
CASP57
DASP57

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875
ChainResidueDetails
CTYR32
DTYR32

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
CTHR35
DTHR35

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284
ChainResidueDetails
CTYR64
DTYR64

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
ChainResidueDetails
CCYS188
DCYS188

site_idSWS_FT_FI7
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
ChainResidueDetails
CCYS188
DCYS188

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
CTYR32
DTYR32

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
CTHR35
DTHR35

226707

PDB entries from 2024-10-30

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