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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6SIU

Crystal structure of IbpAFic2 covalently tethered to Cdc42

Functional Information from GO Data
ChainGOidnamespacecontents
C0000139cellular_componentGolgi membrane
C0001669cellular_componentacrosomal vesicle
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0007015biological_processactin filament organization
C0007030biological_processGolgi organization
C0007163biological_processestablishment or maintenance of cell polarity
C0007165biological_processsignal transduction
C0007229biological_processintegrin-mediated signaling pathway
C0009653biological_processanatomical structure morphogenesis
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0017119cellular_componentCOG complex
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030010biological_processestablishment of cell polarity
C0030036biological_processactin cytoskeleton organization
C0030175cellular_componentfilopodium
C0030225biological_processmacrophage differentiation
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030742molecular_functionGTP-dependent protein binding
C0031274biological_processpositive regulation of pseudopodium assembly
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031996molecular_functionthioesterase binding
C0032427molecular_functionGBD domain binding
C0032467biological_processpositive regulation of cytokinesis
C0032956biological_processregulation of actin cytoskeleton organization
C0032991cellular_componentprotein-containing complex
C0034191molecular_functionapolipoprotein A-I receptor binding
C0034329biological_processcell junction assembly
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0038189biological_processneuropilin signaling pathway
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0044788biological_processhost-mediated perturbation of viral process
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0048549biological_processpositive regulation of pinocytosis
C0051130biological_processpositive regulation of cellular component organization
C0051233cellular_componentspindle midzone
C0051489biological_processregulation of filopodium assembly
C0051491biological_processpositive regulation of filopodium assembly
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051683biological_processestablishment of Golgi localization
C0051988biological_processregulation of attachment of spindle microtubules to kinetochore
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
C0060997biological_processdendritic spine morphogenesis
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0071944cellular_componentcell periphery
C0072384biological_processorganelle transport along microtubule
C0072686cellular_componentmitotic spindle
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D0000139cellular_componentGolgi membrane
D0001669cellular_componentacrosomal vesicle
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006897biological_processendocytosis
D0006911biological_processphagocytosis, engulfment
D0007015biological_processactin filament organization
D0007030biological_processGolgi organization
D0007163biological_processestablishment or maintenance of cell polarity
D0007165biological_processsignal transduction
D0007229biological_processintegrin-mediated signaling pathway
D0009653biological_processanatomical structure morphogenesis
D0010591biological_processregulation of lamellipodium assembly
D0010592biological_processpositive regulation of lamellipodium assembly
D0015630cellular_componentmicrotubule cytoskeleton
D0016020cellular_componentmembrane
D0017119cellular_componentCOG complex
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030010biological_processestablishment of cell polarity
D0030036biological_processactin cytoskeleton organization
D0030175cellular_componentfilopodium
D0030225biological_processmacrophage differentiation
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030742molecular_functionGTP-dependent protein binding
D0031274biological_processpositive regulation of pseudopodium assembly
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031996molecular_functionthioesterase binding
D0032427molecular_functionGBD domain binding
D0032467biological_processpositive regulation of cytokinesis
D0032956biological_processregulation of actin cytoskeleton organization
D0032991cellular_componentprotein-containing complex
D0034191molecular_functionapolipoprotein A-I receptor binding
D0034329biological_processcell junction assembly
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0038189biological_processneuropilin signaling pathway
D0042802molecular_functionidentical protein binding
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0044788biological_processhost-mediated perturbation of viral process
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0048549biological_processpositive regulation of pinocytosis
D0051130biological_processpositive regulation of cellular component organization
D0051233cellular_componentspindle midzone
D0051489biological_processregulation of filopodium assembly
D0051491biological_processpositive regulation of filopodium assembly
D0051492biological_processregulation of stress fiber assembly
D0051496biological_processpositive regulation of stress fiber assembly
D0051683biological_processestablishment of Golgi localization
D0051988biological_processregulation of attachment of spindle microtubules to kinetochore
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
D0060997biological_processdendritic spine morphogenesis
D0061630molecular_functionubiquitin protein ligase activity
D0070062cellular_componentextracellular exosome
D0071944cellular_componentcell periphery
D0072384biological_processorganelle transport along microtubule
D0072686cellular_componentmitotic spindle
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue SO4 A 3801
ChainResidue
AARG3660
ALEU3661
ALYS3665
BLYS3532
site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 3802
ChainResidue
AGLU3537
AHOH3918
AHOH3923
DGLN74
site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 3803
ChainResidue
AARG3725
DLJN203
ASER3611
site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 A 3804
ChainResidue
ATHR3641
AVAL3642
AGLN3643
site_idAC5
Number of Residues5
Detailsbinding site for residue SO4 B 3801
ChainResidue
ALYS3532
BARG3660
BLEU3661
BLYS3665
BHOH3903
site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 B 3802
ChainResidue
BPRO3536
BGLU3537
CGLN74
site_idAC7
Number of Residues4
Detailsbinding site for residue SO4 B 3803
ChainResidue
BTHR3610
BSER3611
BARG3725
BHOH3901
site_idAC8
Number of Residues3
Detailsbinding site for residue SO4 B 3804
ChainResidue
BTHR3641
BVAL3642
BGLN3643
site_idAC9
Number of Residues18
Detailsbinding site for residue GDP C 201
ChainResidue
BGLU3671
CASP11
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CPHE28
CVAL33
CGLN116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CHOH302
CHOH303
site_idAD1
Number of Residues5
Detailsbinding site for residue GOL C 202
ChainResidue
BSER3534
CVAL36
CTHR58
CALA59
CHOH317
site_idAD2
Number of Residues5
Detailsbinding site for residue SO4 C 204
ChainResidue
BSER3761
CSER86
CPRO87
CSER88
CGLN134
site_idAD3
Number of Residues19
Detailsbinding site for residue GDP D 201
ChainResidue
AASN3672
DALA13
DVAL14
DGLY15
DLYS16
DTHR17
DCYS18
DPHE28
DVAL33
DGLN116
DASP118
DSER158
DALA159
DLEU160
DHOH308
DHOH309
DHOH313
DHOH314
DHOH315
site_idAD4
Number of Residues2
Detailsbinding site for residue GOL D 202
ChainResidue
ASER3534
DALA59
site_idAD5
Number of Residues5
Detailsbinding site for residue SO4 D 204
ChainResidue
ASER3761
DSER86
DPRO87
DSER88
DGLN134
site_idAD6
Number of Residues18
Detailsbinding site for Di-peptide LJN C 203 and TYR C 32
ChainResidue
CHOH304
CHOH308
BTHR3669
BLYS3670
BALA3673
BTYR3710
BILE3714
BHIS3717
BGLU3721
BASN3723
BGLY3724
BARG3728
BGLU3751
BILE3754
BCYS3755
BHOH3901
CGLU31
CVAL33
site_idAD7
Number of Residues18
Detailsbinding site for Di-peptide LJN D 203 and TYR D 32
ChainResidue
ATHR3669
ALYS3670
AALA3673
APHE3675
ATYR3710
AILE3714
AHIS3717
AGLY3722
AASN3723
AGLY3724
AARG3728
AGLU3751
ACYS3755
ASO43803
DGLU31
DVAL33
DHOH301
DHOH307
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues274
DetailsDomain: {"description":"Fido 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00791","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues44
DetailsRegion: {"description":"Arm region"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues10
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsPropeptide: {"description":"Removed in mature form","featureId":"PRO_0000030426","evidences":[{"source":"UniProtKB","id":"P61585","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues16
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19745154","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WMO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10211824","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10676816","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-1997","submissionDatabase":"PDB data bank","title":"The structure determination of CDC42Hs and GDP complex.","authors":["Kongsaeree P.","Cerione R.A.","Clardy J.C."]}},{"source":"PDB","id":"1AM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10211824","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10676816","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-1997","submissionDatabase":"PDB data bank","title":"The structure determination of CDC42Hs and GDP complex.","authors":["Kongsaeree P.","Cerione R.A.","Clardy J.C."]}},{"source":"PDB","id":"1A4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19745154","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WMN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622875","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"14506284","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"10676816","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsLipidation: {"description":"S-geranylgeranyl cysteine","evidences":[{"source":"PubMed","id":"10676816","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

257179

PDB entries from 2026-07-29

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