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6SII

T. brucei FPPS in complex with 1-((1H-indol-3-yl)methyl)-N-(3-chlorobenzyl)piperidin-4-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004659molecular_functionprenyltransferase activity
A0008299biological_processisoprenoid biosynthetic process
A0016740molecular_functiontransferase activity
A0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue LEZ A 401
ChainResidue
AILE208
ALYS212
AGLN252
AASP255
AASP256
AMET258
AASP259
AASP273
ACYS279

site_idAC2
Number of Residues4
Detailsbinding site for residue GOL A 402
ChainResidue
AARG160
AARG163
AVAL164
ALEU219

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQVqDDVmD
ChainResidueDetails
AMET247-ASP259

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVeDDim..DnsvtRRG
ChainResidueDetails
ALEU100-GLY114

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PDB entries from 2024-07-24

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