6SHK

High resolution structure of the antimicrobial peptide Dermcidin from human

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008233	molecular_function	peptidase activity
A	0031640	biological_process	killing of cells of another organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 101

Chain	Residue
A	GLU5
A	ASP9
A	HIS38
A	ASP42

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 102

Chain	Residue
A	SER1
A	LYS20
A	ASP24
A	ASP28

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	Peptide: {"description":"DCD-1","featureId":"PRO_0000021084","evidences":[{"source":"PubMed","id":"11694882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17448443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Propeptide: {"featureId":"PRO_0000408312","evidences":[{"source":"PubMed","id":"11694882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25946035","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"23426625","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"23426625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YMK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23426625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YMK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"23426625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YMK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---