6SE3
Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 3-6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| C | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0050661 | molecular_function | NADP binding |
| D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0050661 | molecular_function | NADP binding |
| E | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| E | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| E | 0050661 | molecular_function | NADP binding |
| F | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| F | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| F | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue FAD D 601 |
| Chain | Residue |
| D | ILE8 |
| D | LEU40 |
| D | TRP41 |
| D | ARG51 |
| D | THR60 |
| D | ASN61 |
| D | SER62 |
| D | LEU109 |
| D | VAL110 |
| D | CYS146 |
| D | GLY148 |
| D | GLY9 |
| D | HIS150 |
| D | ALA377 |
| D | THR378 |
| D | NAP602 |
| D | HOH726 |
| D | HOH733 |
| D | HOH736 |
| D | GLY11 |
| D | VAL12 |
| D | SER13 |
| D | PHE31 |
| D | GLU32 |
| D | ARG33 |
| D | GLY39 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for residue NAP D 602 |
| Chain | Residue |
| D | TYR55 |
| D | PHE59 |
| D | ASN61 |
| D | HIS150 |
| D | ASN154 |
| D | PRO156 |
| D | PHE160 |
| D | GLY191 |
| D | LEU192 |
| D | GLY193 |
| D | ASN194 |
| D | SER195 |
| D | ASP198 |
| D | ARG215 |
| D | SER216 |
| D | ARG223 |
| D | LYS280 |
| D | GLU281 |
| D | ALA328 |
| D | THR329 |
| D | GLY330 |
| D | TYR331 |
| D | GLN373 |
| D | FAD601 |
| D | HOH727 |
| D | HOH731 |
| D | HOH735 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue OXY D 603 |
| Chain | Residue |
| D | ASN61 |
| D | LEU375 |
| D | GLY376 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | ILE8 |
| A | GLY9 |
| A | GLY11 |
| A | VAL12 |
| A | SER13 |
| A | PHE31 |
| A | GLU32 |
| A | ARG33 |
| A | GLY39 |
| A | LEU40 |
| A | TRP41 |
| A | GLY50 |
| A | ARG51 |
| A | THR60 |
| A | ASN61 |
| A | SER62 |
| A | LEU109 |
| A | VAL110 |
| A | CYS146 |
| A | HIS150 |
| A | ALA377 |
| A | THR378 |
| A | NAP602 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for residue NAP A 602 |
| Chain | Residue |
| A | TYR55 |
| A | PHE59 |
| A | THR60 |
| A | ASN61 |
| A | PRO156 |
| A | PHE160 |
| A | GLY193 |
| A | ASN194 |
| A | SER195 |
| A | ASP198 |
| A | ARG215 |
| A | SER216 |
| A | ARG223 |
| A | LYS280 |
| A | GLU281 |
| A | ASN302 |
| A | ALA328 |
| A | THR329 |
| A | GLY330 |
| A | FAD601 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue OXY A 603 |
| Chain | Residue |
| A | ASN61 |
| A | GLU281 |
| A | SER374 |
| A | LEU375 |
| A | GLY376 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | binding site for residue FAD B 601 |
| Chain | Residue |
| B | ILE8 |
| B | GLY9 |
| B | GLY11 |
| B | VAL12 |
| B | SER13 |
| B | PHE31 |
| B | GLU32 |
| B | ARG33 |
| B | GLY39 |
| B | LEU40 |
| B | TRP41 |
| B | ARG51 |
| B | THR60 |
| B | ASN61 |
| B | SER62 |
| B | LEU109 |
| B | VAL110 |
| B | CYS146 |
| B | SER147 |
| B | GLY148 |
| B | HIS150 |
| B | ALA377 |
| B | THR378 |
| B | NAP602 |
| B | HOH709 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | binding site for residue NAP B 602 |
| Chain | Residue |
| B | TYR55 |
| B | PHE59 |
| B | ASN61 |
| B | PRO156 |
| B | PHE160 |
| B | GLY191 |
| B | LEU192 |
| B | GLY193 |
| B | ASN194 |
| B | SER195 |
| B | ASP198 |
| B | ARG215 |
| B | SER216 |
| B | ARG223 |
| B | LYS280 |
| B | GLU281 |
| B | ALA328 |
| B | THR329 |
| B | GLY330 |
| B | GLN373 |
| B | FAD601 |
| B | HOH721 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue OXY B 603 |
| Chain | Residue |
| B | ASN61 |
| B | LEU375 |
| B | GLY376 |
| site_id | AD1 |
| Number of Residues | 28 |
| Details | binding site for residue FAD C 601 |
| Chain | Residue |
| C | ILE8 |
| C | GLY9 |
| C | GLY11 |
| C | VAL12 |
| C | SER13 |
| C | PHE31 |
| C | GLU32 |
| C | ARG33 |
| C | GLY39 |
| C | LEU40 |
| C | TRP41 |
| C | ARG51 |
| C | THR60 |
| C | ASN61 |
| C | SER62 |
| C | THR108 |
| C | LEU109 |
| C | VAL110 |
| C | CYS146 |
| C | SER147 |
| C | GLY148 |
| C | HIS150 |
| C | PHE337 |
| C | ALA377 |
| C | THR378 |
| C | NAP602 |
| C | HOH701 |
| C | HOH719 |
| site_id | AD2 |
| Number of Residues | 23 |
| Details | binding site for residue NAP C 602 |
| Chain | Residue |
| C | TYR55 |
| C | PHE59 |
| C | ASN61 |
| C | HIS150 |
| C | PRO156 |
| C | PHE160 |
| C | GLY191 |
| C | LEU192 |
| C | GLY193 |
| C | ASN194 |
| C | SER195 |
| C | ASP198 |
| C | ARG215 |
| C | SER216 |
| C | ARG223 |
| C | LYS280 |
| C | GLU281 |
| C | ALA328 |
| C | THR329 |
| C | GLY330 |
| C | GLN373 |
| C | FAD601 |
| C | HOH729 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue OXY C 603 |
| Chain | Residue |
| C | ASN61 |
| C | LEU375 |
| C | GLY376 |
| site_id | AD4 |
| Number of Residues | 27 |
| Details | binding site for residue FAD E 601 |
| Chain | Residue |
| E | ILE8 |
| E | GLY9 |
| E | GLY11 |
| E | VAL12 |
| E | SER13 |
| E | PHE31 |
| E | GLU32 |
| E | ARG33 |
| E | GLY39 |
| E | LEU40 |
| E | TRP41 |
| E | ARG51 |
| E | THR60 |
| E | ASN61 |
| E | SER62 |
| E | THR108 |
| E | LEU109 |
| E | VAL110 |
| E | CYS146 |
| E | SER147 |
| E | GLY148 |
| E | HIS150 |
| E | ALA377 |
| E | THR378 |
| E | NAP602 |
| E | HOH703 |
| E | HOH707 |
| site_id | AD5 |
| Number of Residues | 22 |
| Details | binding site for residue NAP E 602 |
| Chain | Residue |
| E | TYR55 |
| E | PHE59 |
| E | THR60 |
| E | ASN61 |
| E | HIS150 |
| E | PRO156 |
| E | PHE160 |
| E | GLY191 |
| E | LEU192 |
| E | GLY193 |
| E | ASN194 |
| E | SER195 |
| E | ASP198 |
| E | ARG215 |
| E | SER216 |
| E | ARG223 |
| E | GLU281 |
| E | ALA328 |
| E | THR329 |
| E | GLY330 |
| E | GLN373 |
| E | FAD601 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue OXY E 603 |
| Chain | Residue |
| E | ASN61 |
| E | SER374 |
| E | LEU375 |
| site_id | AD7 |
| Number of Residues | 27 |
| Details | binding site for residue FAD F 601 |
| Chain | Residue |
| F | ILE8 |
| F | GLY9 |
| F | GLY11 |
| F | VAL12 |
| F | SER13 |
| F | PHE31 |
| F | GLU32 |
| F | ARG33 |
| F | GLY39 |
| F | LEU40 |
| F | TRP41 |
| F | ARG51 |
| F | THR60 |
| F | ASN61 |
| F | SER62 |
| F | LEU109 |
| F | VAL110 |
| F | CYS146 |
| F | SER147 |
| F | GLY148 |
| F | HIS150 |
| F | PHE337 |
| F | ALA377 |
| F | THR378 |
| F | NAP602 |
| F | HOH716 |
| F | HOH719 |
| site_id | AD8 |
| Number of Residues | 27 |
| Details | binding site for residue NAP F 602 |
| Chain | Residue |
| F | TYR55 |
| F | PHE59 |
| F | ASN61 |
| F | HIS150 |
| F | PRO156 |
| F | PHE160 |
| F | GLY191 |
| F | LEU192 |
| F | GLY193 |
| F | ASN194 |
| F | SER195 |
| F | ASP198 |
| F | ARG215 |
| F | SER216 |
| F | ARG223 |
| F | LYS280 |
| F | GLU281 |
| F | ALA328 |
| F | THR329 |
| F | GLY330 |
| F | TYR331 |
| F | GLN373 |
| F | FAD601 |
| F | HOH703 |
| F | HOH705 |
| F | HOH708 |
| F | HOH725 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue OXY F 603 |
| Chain | Residue |
| F | ASN61 |
| F | LEU375 |
| F | GLY376 |
