6SCX

Crystal structure of the catalytic domain of human NUDT12 in complex with 7-methyl-guanosine-5'-triphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CD A 501

Chain	Residue
A	CYS284
A	CYS287
A	CYS302
A	CYS307

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CD A 502

Chain	Residue
A	ALA354
A	GLU374
A	MGP505

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CD A 503

Chain	Residue
A	GLU370
A	GLU415

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CD A 504

Chain	Residue
A	HIS251
C	HIS251

---

site_id	AC5
Number of Residues	18
Details	binding site for residue MGP A 505

Chain	Residue
A	ASP322
A	VAL324
A	ILE326
A	GLN342
A	ARG344
A	THR351
A	CYS352
A	ALA354
A	GLY355
A	PHE356
A	TRP390
A	MET397
A	ALA448
A	CD502
A	HOH601
B	VAL313
B	ASN315
B	TYR318

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CD B 501

Chain	Residue
B	CYS284
B	CYS287
B	CYS302
B	CYS307

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CD B 502

Chain	Residue
B	ALA354
B	GLU374
B	MGP504

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CD B 503

Chain	Residue
B	HIS251
B	HIS251

---

site_id	AC9
Number of Residues	16
Details	binding site for residue MGP B 504

Chain	Residue
A	VAL313
A	ASN315
A	TYR318
B	VAL324
B	ILE326
B	ARG344
B	THR351
B	CYS352
B	ALA354
B	GLY355
B	PHE356
B	TRP390
B	MET397
B	ALA448
B	CD502
B	HOH601

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CD C 501

Chain	Residue
C	CYS284
C	CYS287
C	CYS302
C	CYS307

---

site_id	AD2
Number of Residues	3
Details	binding site for residue CD C 502

Chain	Residue
C	ALA354
C	GLU374
C	MGP503

---

site_id	AD3
Number of Residues	16
Details	binding site for residue MGP C 503

Chain	Residue
C	VAL313
C	ASN315
C	TYR318
C	VAL324
C	ILE326
C	ARG344
C	THR351
C	CYS352
C	ALA354
C	GLY355
C	PHE356
C	TRP390
C	MET397
C	ALA448
C	CD502
C	HOH601

---

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GfiepgEtiedAVrREVeEEsG

Chain	Residue	Details
A	GLY355-GLY376

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31875550","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6SCX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9DCN1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCN1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---