6SCH
NADH-dependent variant of CBADH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050009 | molecular_function | isopropanol dehydrogenase (NADP+) activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050009 | molecular_function | isopropanol dehydrogenase (NADP+) activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0050009 | molecular_function | isopropanol dehydrogenase (NADP+) activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050009 | molecular_function | isopropanol dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | THR38 |
| A | ASP198 |
| A | TYR199 |
| A | ARG200 |
| A | ALA242 |
| A | GLY244 |
| A | GLU247 |
| A | ILE265 |
| A | ASN266 |
| A | TYR267 |
| A | LEU294 |
| A | SER39 |
| A | LYS340 |
| A | ZN405 |
| A | MG407 |
| A | HOH501 |
| A | HOH567 |
| A | HOH577 |
| A | HIS42 |
| A | HIS59 |
| A | ASP150 |
| A | GLY174 |
| A | GLY176 |
| A | ALA177 |
| A | VAL178 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 2PE A 402 |
| Chain | Residue |
| A | SER317 |
| A | VAL320 |
| A | THR321 |
| A | VAL323 |
| A | ASP343 |
| A | MG406 |
| A | HOH515 |
| B | VAL320 |
| B | THR321 |
| B | HIS322 |
| B | VAL323 |
| B | TYR324 |
| B | ASP343 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 2PE A 403 |
| Chain | Residue |
| A | GLN165 |
| A | SER169 |
| A | LYS234 |
| A | GLY235 |
| A | ARG238 |
| A | LYS257 |
| A | PRO258 |
| B | LEU93 |
| B | ALA97 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue 2PE A 404 |
| Chain | Residue |
| A | TYR25 |
| A | ASP89 |
| A | ARG91 |
| C | TYR25 |
| C | ARG91 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 405 |
| Chain | Residue |
| A | CYS37 |
| A | SER39 |
| A | HIS59 |
| A | ASP150 |
| A | NAD401 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 406 |
| Chain | Residue |
| A | 2PE402 |
| A | HOH518 |
| B | THR321 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 407 |
| Chain | Residue |
| A | GLY244 |
| A | NAD401 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| A | MET285 |
| B | THR38 |
| B | SER39 |
| B | HIS42 |
| B | HIS59 |
| B | ASP150 |
| B | THR154 |
| B | GLY174 |
| B | GLY176 |
| B | ALA177 |
| B | VAL178 |
| B | VAL197 |
| B | ASP198 |
| B | TYR199 |
| B | ARG200 |
| B | ALA242 |
| B | GLY243 |
| B | GLY244 |
| B | GLU247 |
| B | ILE265 |
| B | ASN266 |
| B | TYR267 |
| B | LEU294 |
| B | ZN404 |
| B | HOH529 |
| B | HOH559 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue 2PE B 402 |
| Chain | Residue |
| A | LEU93 |
| A | ALA97 |
| A | PHE99 |
| B | SER169 |
| B | LYS234 |
| B | GLY235 |
| B | ARG238 |
| B | LYS257 |
| B | PRO258 |
| B | HOH540 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue 2PE B 403 |
| Chain | Residue |
| B | ASP89 |
| B | ARG91 |
| B | HOH557 |
| D | ASP89 |
| D | ARG91 |
| D | HOH570 |
| B | TYR25 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 404 |
| Chain | Residue |
| B | CYS37 |
| B | SER39 |
| B | HIS59 |
| B | ASP150 |
| B | NAD401 |
| site_id | AD3 |
| Number of Residues | 22 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| C | THR38 |
| C | TRP110 |
| C | ASP150 |
| C | THR154 |
| C | ILE173 |
| C | GLY174 |
| C | GLY176 |
| C | VAL178 |
| C | ASP198 |
| C | TYR199 |
| C | ARG200 |
| C | ALA242 |
| C | GLY243 |
| C | GLY244 |
| C | GLU247 |
| C | ILE265 |
| C | ASN266 |
| C | TYR267 |
| C | LYS340 |
| C | ZN403 |
| C | HOH513 |
| C | HOH516 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue 2PE C 402 |
| Chain | Residue |
| C | GLN165 |
| C | SER169 |
| C | LYS234 |
| C | GLY235 |
| C | ASP237 |
| C | ARG238 |
| C | LYS257 |
| D | LEU93 |
| D | ALA97 |
| D | PHE99 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 403 |
| Chain | Residue |
| C | CYS37 |
| C | HIS59 |
| C | ASP150 |
| C | NAD401 |
| site_id | AD6 |
| Number of Residues | 23 |
| Details | binding site for residue NAD D 401 |
| Chain | Residue |
| D | THR38 |
| D | SER39 |
| D | HIS42 |
| D | TRP110 |
| D | ASP150 |
| D | THR154 |
| D | ILE173 |
| D | GLY174 |
| D | GLY176 |
| D | ALA177 |
| D | VAL178 |
| D | ASP198 |
| D | TYR199 |
| D | ARG200 |
| D | ALA242 |
| D | GLY244 |
| D | GLU247 |
| D | ILE265 |
| D | ASN266 |
| D | TYR267 |
| D | ZN404 |
| D | HOH502 |
| D | HOH508 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue 2PE D 402 |
| Chain | Residue |
| C | ALA97 |
| D | GLN165 |
| D | SER169 |
| D | LYS234 |
| D | GLY235 |
| D | ASP237 |
| D | ARG238 |
| D | LYS257 |
| D | HOH526 |
| D | HOH542 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue 2PE D 403 |
| Chain | Residue |
| D | GLU18 |
| D | ARG19 |
| D | TYR123 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 404 |
| Chain | Residue |
| D | CYS37 |
| D | SER39 |
| D | HIS59 |
| D | ASP150 |
| D | NAD401 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaVGEvvevGseV |
| Chain | Residue | Details |
| A | GLY58-VAL72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12381840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20102159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9836873","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9836873","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
