6SC5

dAb3/HOIP-RBR-Ligand2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0008270	molecular_function	zinc ion binding
A	0071797	cellular_component	LUBAC complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue L6B A 2001

Chain	Residue
A	LEU880
A	CYS885
A	HIS887
A	PHE888
A	HIS889

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2002

Chain	Residue
A	CYS699
A	CYS702
A	CYS722
A	CYS725

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 2003

Chain	Residue
A	CYS717
A	CYS719
A	CYS744
A	CYS747

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 2004

Chain	Residue
A	CYS799
A	CYS802
A	CYS817
A	CYS820

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 2005

Chain	Residue
A	CYS825
A	CYS828
A	HIS836
A	CYS841

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 2006

Chain	Residue
A	CYS871
A	CYS874
A	CYS890
A	CYS893

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 2007

Chain	Residue
A	CYS898
A	CYS901
A	HIS926
A	CYS930

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN A 2008

Chain	Residue
A	CYS911
A	CYS916
A	HIS923
A	HIS925

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN A 2009

Chain	Residue
A	CYS969
A	CYS986
A	CYS998
A	HIS1001

---

site_id	AD1
Number of Residues	8
Details	binding site for residue SO4 A 2010

Chain	Residue
A	ASN903
A	LEU1063
A	GLY1064
A	GLN1065
A	HOH2107
A	HOH2116
A	HOH2120
A	HOH2122

---

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 A 2011

Chain	Residue
A	GLY884
A	CYS885
A	MET886
A	HIS887
A	ARG935

---

site_id	AD3
Number of Residues	2
Details	binding site for residue CL A 2012

Chain	Residue
A	TRP798
B	GLY104

---

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 B 201

Chain	Residue
A	HOH2129
B	SER52
B	PRO53
B	ILE54
B	GLY55
B	THR56
B	TYR57

---

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 B 202

Chain	Residue
B	PHE27
B	THR28
B	TYR32

---

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CrHqFCsgCY

Chain	Residue	Details
A	CYS893-TYR902

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Zinc finger: {"description":"RING-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	62
Details	Zinc finger: {"description":"IBR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Zinc finger: {"description":"RING-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"35294289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7V8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V8G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35294289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7V8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V8G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27572974","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---