6SAZ

Cleaved human fetuin-b in complex with crayfish astacin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
B	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
B	0005615	cellular_component	extracellular space
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
D	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
D	0005615	cellular_component	extracellular space

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TIIHELMHAI

Chain	Residue	Details
A	THR89-ILE98

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site_id	PS01254
Number of Residues	119
Details	FETUIN_1 Fetuin family signature 1. CNDsdvlavagfalrdinkdrkdgyvlrlnrvndaqeyrrgglgslfyltldvletdCHvlrkkawqdCgmriffesvygq..CkaifymnnpsrvlylaaynCtlrpvskkkiymtCpdC

Chain	Residue	Details
B	CYS36-CYS154

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site_id	PS01255
Number of Residues	10
Details	FETUIN_2 Fetuin family signature 2. DvLETdCHvL

Chain	Residue	Details
B	ASP87-LEU96

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER315
D	SER315

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
B	ASN37
B	ASN136
D	ASN37
D	ASN136
C	HIS96
C	HIS102

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN182
D	ASN182

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000250|UniProtKB:Q58D62

Chain	Residue	Details
B	THR289
B	THR292
D	THR289
D	THR292

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 403

Chain	Residue	Details
A	HIS92	metal ligand
A	GLU93	proton shuttle (general acid/base)
A	HIS96	metal ligand
A	HIS102	metal ligand
A	TYR149	transition state stabiliser

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site_id	MCSA2
Number of Residues	5
Details	M-CSA 403

Chain	Residue	Details
C	HIS92	metal ligand
C	GLU93	proton shuttle (general acid/base)
C	HIS96	metal ligand
C	HIS102	metal ligand
C	TYR149	transition state stabiliser

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