6SAQ
wild-type NuoEF from Aquifex aeolicus bound to NADH-OH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003954 | molecular_function | NADH dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0022904 | biological_process | respiratory electron transport chain |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048038 | molecular_function | quinone binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| B | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| B | 0010181 | molecular_function | FMN binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048038 | molecular_function | quinone binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0003954 | molecular_function | NADH dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048038 | molecular_function | quinone binding |
| C | 0051536 | molecular_function | iron-sulfur cluster binding |
| C | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| D | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| D | 0010181 | molecular_function | FMN binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048038 | molecular_function | quinone binding |
| D | 0051536 | molecular_function | iron-sulfur cluster binding |
| D | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue FES A 1001 |
| Chain | Residue |
| A | CYS86 |
| A | VAL90 |
| A | CYS91 |
| A | CYS127 |
| A | LEU128 |
| A | ALA130 |
| A | CYS131 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1002 |
| Chain | Residue |
| A | HOH1106 |
| A | HOH1140 |
| A | HOH1158 |
| B | ARG175 |
| B | HOH1277 |
| A | HIS35 |
| A | ASP141 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1003 |
| Chain | Residue |
| A | PHE69 |
| A | ASP71 |
| B | ILE181 |
| B | HIS344 |
| B | GLU345 |
| B | HOH1119 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue FMN B 1001 |
| Chain | Residue |
| B | GLY65 |
| B | ARG66 |
| B | GLY67 |
| B | LYS76 |
| B | ASN92 |
| B | ASP94 |
| B | GLU95 |
| B | SER96 |
| B | TYR180 |
| B | GLY183 |
| B | GLU184 |
| B | GLU185 |
| B | VAL218 |
| B | ASN219 |
| B | ASN220 |
| B | THR223 |
| B | L3W1003 |
| B | HOH1154 |
| B | HOH1164 |
| B | HOH1176 |
| B | HOH1204 |
| B | HOH1210 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 B 1002 |
| Chain | Residue |
| B | THR346 |
| B | CYS347 |
| B | GLY348 |
| B | GLN349 |
| B | CYS350 |
| B | CYS353 |
| B | SER391 |
| B | CYS393 |
| B | GLY396 |
| site_id | AC6 |
| Number of Residues | 27 |
| Details | binding site for residue L3W B 1003 |
| Chain | Residue |
| B | GLY67 |
| B | GLY68 |
| B | ALA69 |
| B | PHE71 |
| B | LYS76 |
| B | GLU95 |
| B | SER96 |
| B | GLU97 |
| B | THR100 |
| B | ASP103 |
| B | TYR180 |
| B | GLU185 |
| B | LYS202 |
| B | TYR205 |
| B | PRO206 |
| B | VAL207 |
| B | THR319 |
| B | FMN1001 |
| B | HOH1107 |
| B | HOH1110 |
| B | HOH1114 |
| B | HOH1124 |
| B | HOH1133 |
| B | HOH1225 |
| B | HOH1252 |
| B | HOH1257 |
| B | HOH1295 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1004 |
| Chain | Residue |
| B | PRO267 |
| B | THR270 |
| B | GLU274 |
| B | LYS278 |
| B | TYR279 |
| B | HOH1142 |
| B | HOH1161 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 1005 |
| Chain | Residue |
| B | ARG273 |
| B | LYS288 |
| B | VAL289 |
| B | SER302 |
| B | HOH1198 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 1006 |
| Chain | Residue |
| B | GLU44 |
| B | ASN48 |
| B | LEU163 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue FES C 1001 |
| Chain | Residue |
| C | GLY129 |
| C | ALA130 |
| C | CYS131 |
| C | CYS86 |
| C | SER88 |
| C | VAL90 |
| C | CYS91 |
| C | CYS127 |
| C | LEU128 |
| site_id | AD2 |
| Number of Residues | 22 |
| Details | binding site for residue FMN D 1001 |
| Chain | Residue |
| D | GLY65 |
| D | ARG66 |
| D | GLY67 |
| D | LYS76 |
| D | ASN92 |
| D | ASP94 |
| D | GLU95 |
| D | SER96 |
| D | TYR180 |
| D | GLY183 |
| D | GLU184 |
| D | GLU185 |
| D | VAL218 |
| D | ASN219 |
| D | ASN220 |
| D | THR223 |
| D | L3W1003 |
| D | HOH1111 |
| D | HOH1124 |
| D | HOH1147 |
| D | HOH1166 |
| D | HOH1194 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue SF4 D 1002 |
| Chain | Residue |
| D | THR346 |
| D | CYS347 |
| D | GLY348 |
| D | GLN349 |
| D | CYS350 |
| D | CYS353 |
| D | SER391 |
| D | CYS393 |
| D | LEU395 |
| D | GLY396 |
| site_id | AD4 |
| Number of Residues | 29 |
| Details | binding site for residue L3W D 1003 |
| Chain | Residue |
| B | TRP235 |
| B | ARG239 |
| D | GLY67 |
| D | GLY68 |
| D | ALA69 |
| D | PHE71 |
| D | LYS76 |
| D | PHE79 |
| D | GLU95 |
| D | SER96 |
| D | GLU97 |
| D | THR100 |
| D | ASP103 |
| D | TYR180 |
| D | GLU185 |
| D | TYR205 |
| D | VAL207 |
| D | THR319 |
| D | FMN1001 |
| D | HOH1106 |
| D | HOH1110 |
| D | HOH1123 |
| D | HOH1131 |
| D | HOH1158 |
| D | HOH1171 |
| D | HOH1175 |
| D | HOH1176 |
| D | HOH1182 |
| D | HOH1189 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 1004 |
| Chain | Residue |
| D | PRO267 |
| D | THR270 |
| D | GLU274 |
| D | LYS278 |
| D | TYR279 |
| D | HOH1178 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 1005 |
| Chain | Residue |
| D | ARG22 |
| D | TYR34 |
| D | GLU116 |
| D | PRO228 |
| D | PHE229 |
| D | SER232 |
| D | HOH1119 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGFGGTGTVIvLteeddive..........AALK |
| Chain | Residue | Details |
| B | LEU314-LYS337 |
| site_id | PS00644 |
| Number of Residues | 16 |
| Details | COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES |
| Chain | Residue | Details |
| B | GLY176-SER191 |
| site_id | PS00645 |
| Number of Residues | 12 |
| Details | COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ETCGqCtPCRvG |
| Chain | Residue | Details |
| B | GLU345-GLY356 |
| site_id | PS01099 |
| Number of Residues | 19 |
| Details | COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DgkFKivpvqCLGaCseAP |
| Chain | Residue | Details |
| A | ASP117-PRO135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
