6S9K
Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002842 | biological_process | positive regulation of T cell mediated immune response to tumor cell |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005080 | molecular_function | protein kinase C binding |
| A | 0005159 | molecular_function | insulin-like growth factor receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006605 | biological_process | protein targeting |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | protein localization |
| A | 0008426 | molecular_function | protein kinase C inhibitor activity |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0022409 | biological_process | positive regulation of cell-cell adhesion |
| A | 0030971 | molecular_function | receptor tyrosine kinase binding |
| A | 0031982 | cellular_component | vesicle |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0032880 | biological_process | regulation of protein localization |
| A | 0042149 | biological_process | cellular response to glucose starvation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045202 | cellular_component | synapse |
| A | 0045664 | biological_process | regulation of neuron differentiation |
| A | 0048167 | biological_process | regulation of synaptic plasticity |
| A | 0050870 | biological_process | positive regulation of T cell activation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098793 | cellular_component | presynapse |
| A | 0140031 | molecular_function | phosphorylation-dependent protein binding |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 1904262 | biological_process | negative regulation of TORC1 signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue CFH A 301 |
| Chain | Residue |
| A | GLU15 |
| A | ASN43 |
| A | LEU44 |
| A | VAL47 |
| A | HOH416 |
| B | PRO143 |
| B | CYS145 |
| B | SER147 |
| B | CYS148 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue CFH A 302 |
| Chain | Residue |
| A | LEU221 |
| A | LEU225 |
| A | ASP228 |
| B | LEU150 |
| B | TYR151 |
| B | LEU154 |
| B | THR158 |
| B | HOH207 |
Functional Information from PROSITE/UniProt
| site_id | PS00796 |
| Number of Residues | 11 |
| Details | 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV |
| Chain | Residue | Details |
| A | ARG42-VAL52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER157 | |
| A | ARG132 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial => ECO:0000269|Ref.7 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylvaline; partial => ECO:0000269|PubMed:14534293, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | VAL2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER71 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P61983 |
| Chain | Residue | Details |
| A | TYR133 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|Ref.7 |
| Chain | Residue | Details |
| A | THR145 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P61983 |
| Chain | Residue | Details |
| A | SER215 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR234 |
