6S8W

Aromatic aminotransferase AroH (Aro8) form Aspergillus fumigatus in complex with PLP (internal aldimine)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005575	cellular_component	cellular_component
A	0006571	biological_process	tyrosine biosynthetic process
A	0008483	molecular_function	transaminase activity
A	0008793	molecular_function	aromatic-amino-acid:2-oxoglutarate aminotransferase activity
A	0009058	biological_process	biosynthetic process
A	0009074	biological_process	aromatic amino acid family catabolic process
A	0019878	biological_process	lysine biosynthetic process via aminoadipic acid
A	0030170	molecular_function	pyridoxal phosphate binding
A	0047536	molecular_function	2-aminoadipate transaminase activity
B	0005575	cellular_component	cellular_component
B	0006571	biological_process	tyrosine biosynthetic process
B	0008483	molecular_function	transaminase activity
B	0008793	molecular_function	aromatic-amino-acid:2-oxoglutarate aminotransferase activity
B	0009058	biological_process	biosynthetic process
B	0009074	biological_process	aromatic amino acid family catabolic process
B	0019878	biological_process	lysine biosynthetic process via aminoadipic acid
B	0030170	molecular_function	pyridoxal phosphate binding
B	0047536	molecular_function	2-aminoadipate transaminase activity
C	0005575	cellular_component	cellular_component
C	0006571	biological_process	tyrosine biosynthetic process
C	0008483	molecular_function	transaminase activity
C	0008793	molecular_function	aromatic-amino-acid:2-oxoglutarate aminotransferase activity
C	0009058	biological_process	biosynthetic process
C	0009074	biological_process	aromatic amino acid family catabolic process
C	0019878	biological_process	lysine biosynthetic process via aminoadipic acid
C	0030170	molecular_function	pyridoxal phosphate binding
C	0047536	molecular_function	2-aminoadipate transaminase activity
D	0005575	cellular_component	cellular_component
D	0006571	biological_process	tyrosine biosynthetic process
D	0008483	molecular_function	transaminase activity
D	0008793	molecular_function	aromatic-amino-acid:2-oxoglutarate aminotransferase activity
D	0009058	biological_process	biosynthetic process
D	0009074	biological_process	aromatic amino acid family catabolic process
D	0019878	biological_process	lysine biosynthetic process via aminoadipic acid
D	0030170	molecular_function	pyridoxal phosphate binding
D	0047536	molecular_function	2-aminoadipate transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue PLP A 601

Chain	Residue
A	GLY184
A	SER345
A	SER347
A	LYS348
A	ARG355
B	TYR149
B	GLN378
A	SER185
A	THR186
A	PHE210
A	ILE262
A	ASN267
A	ASP295
A	PRO297
A	TYR298

---

site_id	AC2
Number of Residues	6
Details	binding site for residue FMT A 602

Chain	Residue
A	LEU75
A	GLY92
A	GLY93
B	PHE210
B	ASN267
B	ARG498

---

site_id	AC3
Number of Residues	7
Details	binding site for residue FMT D 601

Chain	Residue
C	LEU75
C	GLY92
C	GLY93
D	PHE210
D	ASN267
D	PHE442
D	ARG498

---

site_id	AC4
Number of Residues	16
Details	binding site for Di-peptide PLP B 601 and LYS B 348

Chain	Residue
A	TYR149
A	GLN378
B	GLY184
B	SER185
B	THR186
B	PHE210
B	ASN267
B	ASP295
B	PRO297
B	TYR298
B	SER345
B	PHE346
B	SER347
B	VAL349
B	ARG355
B	MET441

---

site_id	AC5
Number of Residues	16
Details	binding site for Di-peptide PLP C 601 and LYS C 348

Chain	Residue
C	GLY184
C	SER185
C	THR186
C	PHE210
C	ILE262
C	ASN267
C	ASP295
C	PRO297
C	TYR298
C	SER345
C	PHE346
C	SER347
C	VAL349
C	ARG355
D	TYR149
D	GLN378

---

site_id	AC6
Number of Residues	16
Details	binding site for Di-peptide PLP D 602 and LYS D 348

Chain	Residue
C	GLY93
C	TYR149
C	GLN378
D	GLY184
D	SER185
D	THR186
D	PHE210
D	ASN267
D	ASP295
D	PRO297
D	TYR298
D	SER345
D	PHE346
D	SER347
D	VAL349
D	ARG355

---

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. LIHNPPY

Chain	Residue	Details
A	LEU168-TYR174

---

site_id	PS00879
Number of Residues	18
Details	ODR_DC_2_2 Orn/DAP/Arg decarboxylases family 2 signature 2. AarylktPgLISLGGGLP

Chain	Residue	Details
A	ALA78-PRO95

---