6S87

Crystal structure of 2-methylcitrate synthase (PrpC) from Pseudomonas aeruginosa in complex with oxaloacetate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004108	molecular_function	citrate (Si)-synthase activity
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0019679	biological_process	propionate metabolic process, methylcitrate cycle
A	0036440	molecular_function	citrate synthase activity
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
A	0050440	molecular_function	2-methylcitrate synthase activity
B	0004108	molecular_function	citrate (Si)-synthase activity
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0006099	biological_process	tricarboxylic acid cycle
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0019679	biological_process	propionate metabolic process, methylcitrate cycle
B	0036440	molecular_function	citrate synthase activity
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0050440	molecular_function	2-methylcitrate synthase activity
C	0004108	molecular_function	citrate (Si)-synthase activity
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0019679	biological_process	propionate metabolic process, methylcitrate cycle
C	0036440	molecular_function	citrate synthase activity
C	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
C	0050440	molecular_function	2-methylcitrate synthase activity
D	0004108	molecular_function	citrate (Si)-synthase activity
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0006099	biological_process	tricarboxylic acid cycle
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0019679	biological_process	propionate metabolic process, methylcitrate cycle
D	0036440	molecular_function	citrate synthase activity
D	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
D	0050440	molecular_function	2-methylcitrate synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 401

Chain	Residue
A	GLY224
A	ALA225
A	ASN226
A	ASP312
A	THR330
A	PHE333
A	HOH502
A	HOH530

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL B 401

Chain	Residue
B	GLN118
B	ASP121
B	GLU111

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL B 402

Chain	Residue
B	GLY224
B	ALA225
B	ASN226
B	ASP312
B	THR330

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL C 401

Chain	Residue
C	GLY224
C	ALA225
C	ASN226
C	ASP312
C	THR330
C	PHE333

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL D 401

Chain	Residue
D	ARG139
D	ASN150
D	LEU163
D	GLY166
D	HOH571

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL D 402

Chain	Residue
C	THR202
C	ARG356
C	HOH538
D	ASN190
D	ALA191
D	HIS222
D	OAA403

---

site_id	AC7
Number of Residues	8
Details	binding site for residue OAA D 403

Chain	Residue
C	ARG356
D	HIS187
D	ASN190
D	HIS222
D	HIS261
D	ARG270
D	ARG337
D	GOL402

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Functional Information from PROSITE/UniProt

site_id	PS00480
Number of Residues	13
Details	CITRATE_SYNTHASE Citrate synthase signature. GFGHaIy.KdsDPR

Chain	Residue	Details
A	GLY258-ARG270

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