6S7Q
Crystal structure of ergothioneine degrading enzyme Ergothionase from Treponema denticola in complex with desmethyl-ergothioneine sulfonic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004397 | molecular_function | histidine ammonia-lyase activity |
| A | 0006548 | biological_process | L-histidine catabolic process |
| A | 0016841 | molecular_function | ammonia-lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004397 | molecular_function | histidine ammonia-lyase activity |
| B | 0006548 | biological_process | L-histidine catabolic process |
| B | 0016841 | molecular_function | ammonia-lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004397 | molecular_function | histidine ammonia-lyase activity |
| C | 0006548 | biological_process | L-histidine catabolic process |
| C | 0016841 | molecular_function | ammonia-lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004397 | molecular_function | histidine ammonia-lyase activity |
| D | 0006548 | biological_process | L-histidine catabolic process |
| D | 0016841 | molecular_function | ammonia-lyase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004397 | molecular_function | histidine ammonia-lyase activity |
| E | 0006548 | biological_process | L-histidine catabolic process |
| E | 0016841 | molecular_function | ammonia-lyase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004397 | molecular_function | histidine ammonia-lyase activity |
| F | 0006548 | biological_process | L-histidine catabolic process |
| F | 0016841 | molecular_function | ammonia-lyase activity |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004397 | molecular_function | histidine ammonia-lyase activity |
| G | 0006548 | biological_process | L-histidine catabolic process |
| G | 0016841 | molecular_function | ammonia-lyase activity |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004397 | molecular_function | histidine ammonia-lyase activity |
| H | 0006548 | biological_process | L-histidine catabolic process |
| H | 0016841 | molecular_function | ammonia-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue KZ5 A 501 |
| Chain | Residue |
| A | TYR54 |
| A | ALA408 |
| A | GLU412 |
| B | ARG281 |
| D | GLY380 |
| D | THR381 |
| D | LYS384 |
| A | VAL60 |
| A | GLY61 |
| A | HIS84 |
| A | GLU143 |
| A | ILE146 |
| A | SER195 |
| A | ASN311 |
| A | PHE327 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue KZ5 C 502 |
| Chain | Residue |
| B | GLY380 |
| B | THR381 |
| B | LYS384 |
| C | TYR54 |
| C | VAL60 |
| C | GLY61 |
| C | HIS84 |
| C | GLU143 |
| C | ILE146 |
| C | SER195 |
| C | ASN311 |
| C | ALA408 |
| C | GLU412 |
| D | ARG281 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue KZ5 D 501 |
| Chain | Residue |
| A | GLY380 |
| A | THR381 |
| A | LYS384 |
| C | ARG281 |
| D | TYR54 |
| D | VAL60 |
| D | GLY61 |
| D | HIS84 |
| D | GLU143 |
| D | ILE146 |
| D | SER195 |
| D | ASN311 |
| D | PHE327 |
| D | ALA408 |
| D | GLU412 |
| D | HOH606 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue KZ5 F 501 |
| Chain | Residue |
| E | ARG281 |
| F | TYR54 |
| F | VAL60 |
| F | GLY61 |
| F | HIS84 |
| F | GLU143 |
| F | SER195 |
| F | ASN311 |
| F | ALA408 |
| F | GLU412 |
| G | GLY380 |
| G | THR381 |
| G | LYS384 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue KZ5 G 501 |
| Chain | Residue |
| F | GLY380 |
| F | THR381 |
| F | LYS384 |
| G | TYR54 |
| G | VAL60 |
| G | GLY61 |
| G | HIS84 |
| G | GLU143 |
| G | ILE146 |
| G | SER195 |
| G | ASN311 |
| G | PHE327 |
| G | GLU412 |
| H | ARG281 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide KZ5 C 501 and LYS C 384 |
| Chain | Residue |
| A | ARG281 |
| B | TYR54 |
| B | VAL60 |
| B | GLY61 |
| B | HIS84 |
| B | SER139 |
| B | ILE141 |
| B | GLU143 |
| B | ILE146 |
| B | SER195 |
| B | ASN311 |
| B | PHE327 |
| B | ALA408 |
| B | GLU412 |
| C | GLY380 |
| C | THR381 |
| C | ILE382 |
| C | GLN383 |
| C | THR385 |
| C | PHE386 |
| C | MET388 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide KZ5 E 501 and LYS E 384 |
| Chain | Residue |
| E | THR387 |
| E | MET388 |
| H | TYR54 |
| H | VAL60 |
| H | GLY61 |
| H | HIS84 |
| H | SER139 |
| H | ILE146 |
| H | THR147 |
| H | SER195 |
| H | ASN311 |
| H | LEU407 |
| H | GLU412 |
| E | GLY380 |
| E | THR381 |
| E | ILE382 |
| E | GLN383 |
| E | THR385 |
| E | PHE386 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide KZ5 H 501 and LYS H 384 |
| Chain | Residue |
| E | TYR54 |
| E | GLY61 |
| E | HIS84 |
| E | SER139 |
| E | ILE141 |
| E | GLU143 |
| E | ILE146 |
| E | ALA408 |
| E | GLU412 |
| F | ARG281 |
| H | GLY380 |
| H | THR381 |
| H | ILE382 |
| H | GLN383 |
| H | THR385 |
| H | PHE386 |
| H | MET388 |
