6S7Q

Crystal structure of ergothioneine degrading enzyme Ergothionase from Treponema denticola in complex with desmethyl-ergothioneine sulfonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016841	molecular_function	ammonia-lyase activity
B	0003824	molecular_function	catalytic activity
B	0016841	molecular_function	ammonia-lyase activity
C	0003824	molecular_function	catalytic activity
C	0016841	molecular_function	ammonia-lyase activity
D	0003824	molecular_function	catalytic activity
D	0016841	molecular_function	ammonia-lyase activity
E	0003824	molecular_function	catalytic activity
E	0016841	molecular_function	ammonia-lyase activity
F	0003824	molecular_function	catalytic activity
F	0016841	molecular_function	ammonia-lyase activity
G	0003824	molecular_function	catalytic activity
G	0016841	molecular_function	ammonia-lyase activity
H	0003824	molecular_function	catalytic activity
H	0016841	molecular_function	ammonia-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue KZ5 A 501

Chain	Residue
A	TYR54
A	ALA408
A	GLU412
B	ARG281
D	GLY380
D	THR381
D	LYS384
A	VAL60
A	GLY61
A	HIS84
A	GLU143
A	ILE146
A	SER195
A	ASN311
A	PHE327

---

site_id	AC2
Number of Residues	14
Details	binding site for residue KZ5 C 502

Chain	Residue
B	GLY380
B	THR381
B	LYS384
C	TYR54
C	VAL60
C	GLY61
C	HIS84
C	GLU143
C	ILE146
C	SER195
C	ASN311
C	ALA408
C	GLU412
D	ARG281

---

site_id	AC3
Number of Residues	16
Details	binding site for residue KZ5 D 501

Chain	Residue
A	GLY380
A	THR381
A	LYS384
C	ARG281
D	TYR54
D	VAL60
D	GLY61
D	HIS84
D	GLU143
D	ILE146
D	SER195
D	ASN311
D	PHE327
D	ALA408
D	GLU412
D	HOH606

---

site_id	AC4
Number of Residues	13
Details	binding site for residue KZ5 F 501

Chain	Residue
E	ARG281
F	TYR54
F	VAL60
F	GLY61
F	HIS84
F	GLU143
F	SER195
F	ASN311
F	ALA408
F	GLU412
G	GLY380
G	THR381
G	LYS384

---

site_id	AC5
Number of Residues	14
Details	binding site for residue KZ5 G 501

Chain	Residue
F	GLY380
F	THR381
F	LYS384
G	TYR54
G	VAL60
G	GLY61
G	HIS84
G	GLU143
G	ILE146
G	SER195
G	ASN311
G	PHE327
G	GLU412
H	ARG281

---

site_id	AC6
Number of Residues	21
Details	binding site for Di-peptide KZ5 C 501 and LYS C 384

Chain	Residue
A	ARG281
B	TYR54
B	VAL60
B	GLY61
B	HIS84
B	SER139
B	ILE141
B	GLU143
B	ILE146
B	SER195
B	ASN311
B	PHE327
B	ALA408
B	GLU412
C	GLY380
C	THR381
C	ILE382
C	GLN383
C	THR385
C	PHE386
C	MET388

---

site_id	AC7
Number of Residues	19
Details	binding site for Di-peptide KZ5 E 501 and LYS E 384

Chain	Residue
E	THR387
E	MET388
H	TYR54
H	VAL60
H	GLY61
H	HIS84
H	SER139
H	ILE146
H	THR147
H	SER195
H	ASN311
H	LEU407
H	GLU412
E	GLY380
E	THR381
E	ILE382
E	GLN383
E	THR385
E	PHE386

---

site_id	AC8
Number of Residues	17
Details	binding site for Di-peptide KZ5 H 501 and LYS H 384

Chain	Residue
E	TYR54
E	GLY61
E	HIS84
E	SER139
E	ILE141
E	GLU143
E	ILE146
E	ALA408
E	GLU412
F	ARG281
H	GLY380
H	THR381
H	ILE382
H	GLN383
H	THR385
H	PHE386
H	MET388

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