6S7C
Crystal structure of CARM1 in complex with inhibitor UM079
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue KY2 A 501 |
| Chain | Residue |
| A | TYR149 |
| A | LYS241 |
| A | VAL242 |
| A | GLU243 |
| A | GLU257 |
| A | MET259 |
| A | GLU266 |
| A | MET268 |
| A | SER271 |
| A | HIS414 |
| A | TRP415 |
| A | PHE150 |
| A | TYR153 |
| A | MET162 |
| A | ARG168 |
| A | GLY192 |
| A | GLU214 |
| A | ALA215 |
| A | GLY240 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue KY2 B 501 |
| Chain | Residue |
| B | PHE137 |
| B | TYR149 |
| B | PHE150 |
| B | TYR153 |
| B | MET162 |
| B | GLY192 |
| B | CYS193 |
| B | GLU214 |
| B | ALA215 |
| B | GLY240 |
| B | LYS241 |
| B | VAL242 |
| B | GLU243 |
| B | GLU257 |
| B | MET259 |
| B | GLY260 |
| B | GLU266 |
| B | MET268 |
| B | SER271 |
| B | HIS414 |
| B | TRP415 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue KY2 C 501 |
| Chain | Residue |
| C | TYR149 |
| C | PHE150 |
| C | TYR153 |
| C | ARG168 |
| C | GLY192 |
| C | GLU214 |
| C | GLY240 |
| C | LYS241 |
| C | VAL242 |
| C | GLU243 |
| C | GLU257 |
| C | MET259 |
| C | GLU266 |
| C | MET268 |
| C | SER271 |
| C | TRP415 |
| C | HOH632 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue KY2 D 501 |
| Chain | Residue |
| D | TYR149 |
| D | PHE150 |
| D | TYR153 |
| D | ARG168 |
| D | GLY192 |
| D | GLU214 |
| D | GLY240 |
| D | LYS241 |
| D | VAL242 |
| D | GLU243 |
| D | GLU257 |
| D | MET259 |
| D | GLU266 |
| D | MET268 |
| D | SER271 |
| D | TRP415 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21410432 |
| Chain | Residue | Details |
| A | GLN159 | |
| B | GLU214 | |
| B | GLU243 | |
| B | SER271 | |
| C | GLN159 | |
| C | ARG168 | |
| C | GLY192 | |
| C | GLU214 | |
| C | GLU243 | |
| C | SER271 | |
| D | GLN159 | |
| A | ARG168 | |
| D | ARG168 | |
| D | GLY192 | |
| D | GLU214 | |
| D | GLU243 | |
| D | SER271 | |
| A | GLY192 | |
| A | GLU214 | |
| A | GLU243 | |
| A | SER271 | |
| B | GLN159 | |
| B | ARG168 | |
| B | GLY192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
| Chain | Residue | Details |
| A | SER216 | |
| B | SER216 | |
| C | SER216 | |
| D | SER216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 |
| Chain | Residue | Details |
| A | LYS227 | |
| B | LYS227 | |
| C | LYS227 | |
| D | LYS227 |
