6S71
Crystal structure of CARM1 in complex with inhibitor WH5C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue KYE A 501 |
| Chain | Residue |
| A | TYR149 |
| A | SER195 |
| A | ILE197 |
| A | LEU198 |
| A | GLU214 |
| A | ALA215 |
| A | GLY240 |
| A | LYS241 |
| A | VAL242 |
| A | GLU243 |
| A | GLU257 |
| A | PHE150 |
| A | MET259 |
| A | GLU266 |
| A | MET268 |
| A | SER271 |
| A | TRP415 |
| A | HOH606 |
| A | HOH666 |
| A | TYR153 |
| A | GLN159 |
| A | MET162 |
| A | ARG168 |
| A | GLY192 |
| A | CYS193 |
| A | GLY194 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ASP392 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ALA350 |
| A | LYS351 |
| A | SER352 |
| A | TRP390 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | binding site for residue KYE B 501 |
| Chain | Residue |
| B | TYR149 |
| B | PHE150 |
| B | TYR153 |
| B | GLN159 |
| B | ARG168 |
| B | GLY192 |
| B | CYS193 |
| B | ILE197 |
| B | LEU198 |
| B | GLU214 |
| B | ALA215 |
| B | GLY240 |
| B | LYS241 |
| B | VAL242 |
| B | GLU243 |
| B | GLU257 |
| B | MET259 |
| B | TYR261 |
| B | GLU266 |
| B | MET268 |
| B | SER271 |
| B | HIS414 |
| B | TRP415 |
| B | HOH650 |
| B | HOH677 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | HOH612 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | GLN148 |
| B | TYR149 |
| B | PHE152 |
| B | GLU266 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | binding site for residue KYE C 501 |
| Chain | Residue |
| C | TYR149 |
| C | PHE150 |
| C | TYR153 |
| C | GLN159 |
| C | ARG168 |
| C | GLY192 |
| C | CYS193 |
| C | GLY194 |
| C | ILE197 |
| C | LEU198 |
| C | GLU214 |
| C | ALA215 |
| C | GLY240 |
| C | LYS241 |
| C | VAL242 |
| C | GLU243 |
| C | GLU257 |
| C | MET259 |
| C | GLU266 |
| C | MET268 |
| C | SER271 |
| C | HIS414 |
| C | TRP415 |
| C | HOH634 |
| C | HOH656 |
| C | HOH669 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| C | ASP392 |
| C | HOH667 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | binding site for residue KYE D 501 |
| Chain | Residue |
| D | ALA215 |
| D | GLY240 |
| D | LYS241 |
| D | VAL242 |
| D | GLU243 |
| D | GLU257 |
| D | MET259 |
| D | MET268 |
| D | SER271 |
| D | HIS414 |
| D | TRP415 |
| D | HOH621 |
| D | HOH623 |
| D | HOH627 |
| D | HOH677 |
| D | TYR149 |
| D | PHE150 |
| D | TYR153 |
| D | GLN159 |
| D | ARG168 |
| D | GLY192 |
| D | CYS193 |
| D | GLY194 |
| D | LEU198 |
| D | GLU214 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| D | GLN148 |
| D | GLU266 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| D | ASP392 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21410432 |
| Chain | Residue | Details |
| A | GLN159 | |
| B | GLU214 | |
| B | GLU243 | |
| B | SER271 | |
| C | GLN159 | |
| C | ARG168 | |
| C | GLY192 | |
| C | GLU214 | |
| C | GLU243 | |
| C | SER271 | |
| D | GLN159 | |
| A | ARG168 | |
| D | ARG168 | |
| D | GLY192 | |
| D | GLU214 | |
| D | GLU243 | |
| D | SER271 | |
| A | GLY192 | |
| A | GLU214 | |
| A | GLU243 | |
| A | SER271 | |
| B | GLN159 | |
| B | ARG168 | |
| B | GLY192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
| Chain | Residue | Details |
| A | SER216 | |
| B | SER216 | |
| C | SER216 | |
| D | SER216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 |
| Chain | Residue | Details |
| A | LYS227 | |
| B | LYS227 | |
| C | LYS227 | |
| D | LYS227 |
