6S6V

Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
A	0003677	molecular_function	DNA binding
A	0004519	molecular_function	endonuclease activity
A	0004527	molecular_function	exonuclease activity
A	0004529	molecular_function	DNA exonuclease activity
A	0005515	molecular_function	protein binding
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006274	biological_process	DNA replication termination
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	1990238	molecular_function	double-stranded DNA endonuclease activity
A	1990391	cellular_component	DNA repair complex
B	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
B	0003677	molecular_function	DNA binding
B	0004519	molecular_function	endonuclease activity
B	0004527	molecular_function	exonuclease activity
B	0004529	molecular_function	DNA exonuclease activity
B	0005515	molecular_function	protein binding
B	0006259	biological_process	DNA metabolic process
B	0006260	biological_process	DNA replication
B	0006274	biological_process	DNA replication termination
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0008408	molecular_function	3'-5' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	1990238	molecular_function	double-stranded DNA endonuclease activity
B	1990391	cellular_component	DNA repair complex
C	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004527	molecular_function	exonuclease activity
C	0004529	molecular_function	DNA exonuclease activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication
C	0006274	biological_process	DNA replication termination
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006310	biological_process	DNA recombination
C	0008296	molecular_function	3'-5'-DNA exonuclease activity
C	0016887	molecular_function	ATP hydrolysis activity
C	1990238	molecular_function	double-stranded DNA endonuclease activity
C	1990391	cellular_component	DNA repair complex
D	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004527	molecular_function	exonuclease activity
D	0004529	molecular_function	DNA exonuclease activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006260	biological_process	DNA replication
D	0006274	biological_process	DNA replication termination
D	0006281	biological_process	DNA repair
D	0006302	biological_process	double-strand break repair
D	0006310	biological_process	DNA recombination
D	0008296	molecular_function	3'-5'-DNA exonuclease activity
D	0016887	molecular_function	ATP hydrolysis activity
D	1990238	molecular_function	double-stranded DNA endonuclease activity
D	1990391	cellular_component	DNA repair complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 501

Chain	Residue
A	ASP8
A	HIS10
A	ASP48
A	HIS224
A	MN502

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MN A 502

Chain	Residue
A	MN501
A	ASP48
A	ASN83
A	HIS184
A	HIS222

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MN B 501

Chain	Residue
B	ASP8
B	HIS10
B	ASP48
B	HIS222
B	HIS224
B	MN502

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MN B 502

Chain	Residue
B	ASP8
B	ASP48
B	ASN83
B	HIS184
B	HIS222
B	MN501

---

site_id	AC5
Number of Residues	3
Details	binding site for residue MG C 1102

Chain	Residue
C	THR44
C	GLN155
D	AGS1101

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG D 1102

Chain	Residue
C	AGS1101
D	THR44
D	GLN155

---

site_id	AC7
Number of Residues	23
Details	binding site for Di-peptide AGS C 1101 and ARG C 946

Chain	Residue
C	TYR922
C	GLU935
C	VAL936
C	ASP938
C	VAL945
C	ASP947
C	THR950
C	SER952
C	GLY954
C	GLU955
D	ASN12
D	SER13
D	GLY40
D	GLY42
D	LYS43
D	THR44
D	THR45
D	ARG60
D	LEU71
D	MET72
D	ARG74
D	GLN155
D	MG1102

---

site_id	AC8
Number of Residues	44
Details	binding site for Di-peptide AGS C 1101 and ASN D 12

Chain	Residue
C	ASN10
C	LEU11
C	SER13
C	LEU14
C	GLY40
C	GLY42
C	LYS43
C	THR44
C	THR45
C	ARG60
C	LEU71
C	MET72
C	THR73
C	ARG74
C	GLN155
C	TYR922
C	ARG946
C	THR950
C	SER952
C	GLY954
C	GLU955
C	HIS1016
C	MG1102
D	LEU11
D	SER13
D	GLY40
D	GLY42
D	LYS43
D	THR44
D	THR45
D	ARG60
D	LEU71
D	MET72
D	THR73
D	ARG74
D	GLN155
D	TYR922
D	ARG946
D	THR950
D	SER952
D	GLY953
D	GLY954
D	GLU955
D	MG1102

---

site_id	AC9
Number of Residues	45
Details	binding site for Di-peptide AGS C 1101 and LYS D 43

Chain	Residue
C	GLY40
C	GLY42
C	THR44
C	THR45
C	LEU46
C	ARG60
C	LEU71
C	MET72
C	THR73
C	ARG74
C	GLN155
C	TYR922
C	ARG946
C	THR950
C	SER952
C	GLY954
C	GLU955
C	HIS1016
C	MG1102
D	ASN12
D	SER13
D	PRO38
D	GLY40
D	GLY42
D	THR44
D	THR45
D	LEU46
D	ARG60
D	LEU71
D	MET72
D	ARG74
D	GLN155
D	TYR922
D	ARG946
D	THR950
D	SER952
D	GLY953
D	GLY954
D	GLU955
D	ILE1014
D	MG1102
C	ASN12
C	SER13
C	GLY37
C	PRO38

---

site_id	AD1
Number of Residues	26
Details	binding site for Di-peptide AGS D 1101 and ARG D 946

Chain	Residue
C	ASN12
C	SER13
C	GLY40
C	GLY42
C	LYS43
C	THR44
C	THR45
C	ARG60
C	LEU71
C	MET72
C	THR73
C	ARG74
C	GLN155
C	HIS1016
C	MG1102
D	TYR922
D	GLU935
D	VAL936
D	ASP938
D	VAL945
D	ASP947
D	THR950
D	SER952
D	GLY953
D	GLY954
D	GLU955

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
C	GLY37
D	GLY37

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