6S5H

Structure of the human RAB38 in complex with GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005739	cellular_component	mitochondrion
A	0005764	cellular_component	lysosome
A	0005769	cellular_component	early endosome
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006886	biological_process	intracellular protein transport
A	0007005	biological_process	mitochondrion organization
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0012505	cellular_component	endomembrane system
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0030670	cellular_component	phagocytic vesicle membrane
A	0030742	molecular_function	GTP-dependent protein binding
A	0031090	cellular_component	organelle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031905	cellular_component	early endosome lumen
A	0031982	cellular_component	vesicle
A	0032438	biological_process	melanosome organization
A	0033162	cellular_component	melanosome membrane
A	0035612	molecular_function	AP-2 adaptor complex binding
A	0035646	biological_process	endosome to melanosome transport
A	0035650	molecular_function	AP-1 adaptor complex binding
A	0035651	molecular_function	AP-3 adaptor complex binding
A	0036461	molecular_function	BLOC-2 complex binding
A	0042470	cellular_component	melanosome
A	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
A	0044297	cellular_component	cell body
A	0045335	cellular_component	phagocytic vesicle
A	0046872	molecular_function	metal ion binding
A	0048023	biological_process	positive regulation of melanin biosynthetic process
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0060155	biological_process	platelet dense granule organization
A	0072657	biological_process	protein localization to membrane
A	0090383	biological_process	phagosome acidification
A	1903232	biological_process	melanosome assembly
A	1904377	biological_process	positive regulation of protein localization to cell periphery
A	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue GTP A 301

Chain	Residue
A	LEU18
A	SER36
A	TYR38
A	ALA40
A	THR41
A	GLY68
A	ASN127
A	LYS128
A	ASP130
A	SER159
A	ALA160
A	GLY19
A	LYS161
A	EDO304
A	MG311
A	HOH411
A	HOH434
A	HOH454
A	HOH474
A	VAL20
A	GLY21
A	LYS22
A	THR23
A	SER24
A	PHE34
A	SER35

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	MET75
A	TYR79
A	TYR79
A	HOH402

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 303

Chain	Residue
A	LYS27
A	ASN33
A	SER35
A	ARG39
A	ASP109
A	PRO119
A	HOH468

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 304

Chain	Residue
A	SER36
A	GLU149
A	LYS161
A	GTP301
A	HOH420

---

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 305

Chain	Residue
A	LEU18
A	HOH417

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 306

Chain	Residue
A	PHE46
A	ARG77
A	ARG81

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 307

Chain	Residue
A	VAL30
A	GLN32
A	LEU48
A	LYS49
A	VAL50

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 308

Chain	Residue
A	HOH418
A	HOH430
A	HOH430

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 309

Chain	Residue
A	ASN139

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 310

Chain	Residue
A	PHE98
A	HOH410
A	HOH456
A	HOH471

---

site_id	AD2
Number of Residues	5
Details	binding site for residue MG A 311

Chain	Residue
A	THR23
A	THR41
A	GTP301
A	HOH411
A	HOH434

---

site_id	AD3
Number of Residues	4
Details	binding site for residue BR A 312

Chain	Residue
A	GLN69
A	ARG94
A	PRO95
A	ALA96

---

site_id	AD4
Number of Residues	2
Details	binding site for residue BR A 313

Chain	Residue
A	HOH506
A	HOH506

---

site_id	AD5
Number of Residues	3
Details	binding site for residue BR A 314

Chain	Residue
A	ASN106
A	HIS150
A	HOH455

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	32
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGKTSIIKrYvhqnfsshyratigvd..FALK

Chain	Residue	Details
A	LEU18-LYS49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Motif: {"description":"Switch 1","evidences":[{"source":"UniProtKB","id":"Q13637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	13
Details	Motif: {"description":"Switch 2","evidences":[{"source":"UniProtKB","id":"Q13637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2019","submissionDatabase":"PDB data bank","title":"Structure of the human RAB38 in complex with GTP.","authors":["Diaz-Saez L.","a Jung S.","Huber K.","von Delft F.","Arrowsmith C.H.","Edwards A.","Bountra C."]}},{"source":"PDB","id":"6S5H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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