6S5F
Structure of the human RAB39B in complex with GMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000421 | cellular_component | autophagosome membrane |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006914 | biological_process | autophagy |
| A | 0010506 | biological_process | regulation of autophagy |
| A | 0015031 | biological_process | protein transport |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031489 | molecular_function | myosin V binding |
| A | 0031982 | cellular_component | vesicle |
| A | 0032482 | biological_process | Rab protein signal transduction |
| A | 0043005 | cellular_component | neuron projection |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050808 | biological_process | synapse organization |
| A | 0120281 | cellular_component | autolysosome membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue GLY A 301 |
| Chain | Residue |
| A | TRP5 |
| A | LEU6 |
| A | SER191 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for residue GNP A 302 |
| Chain | Residue |
| A | CYS23 |
| A | PHE33 |
| A | ALA34 |
| A | GLN35 |
| A | SER37 |
| A | PRO39 |
| A | THR40 |
| A | GLY67 |
| A | HIS123 |
| A | LYS124 |
| A | ASP126 |
| A | LEU127 |
| A | SER153 |
| A | ALA154 |
| A | ARG155 |
| A | MG304 |
| A | HOH416 |
| A | HOH435 |
| A | HOH442 |
| A | HOH465 |
| A | HOH472 |
| A | SER17 |
| A | THR18 |
| A | VAL19 |
| A | GLY20 |
| A | LYS21 |
| A | SER22 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | THR181 |
| A | ILE182 |
| A | HOH409 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 304 |
| Chain | Residue |
| A | SER22 |
| A | THR40 |
| A | GNP302 |
| A | HOH416 |
| A | HOH442 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"JUL-2019","submissionDatabase":"PDB data bank","title":"Structure of the human RAB39B in complex with GMPPNP.","authors":["Diaz-Saez L.","Jung S.","Huber K.","von Delft F.","Arrowsmith C.H.","Edwards A.","Bountra C."]}},{"source":"PDB","id":"6S5F","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2019","submissionDatabase":"PDB data bank","title":"Structure of the human RAB39B in complex with GMPPNP.","authors":["Diaz-Saez L.","Jung S.","Huber K.","von Delft F.","Arrowsmith C.H.","Edwards A.","Bountra C."]}},{"source":"PDB","id":"6S5F","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2019","submissionDatabase":"PDB data bank","title":"Structure of the human RAB39B in complex with GMPPNP.","authors":["Diaz-Saez L.","Jung S.","Huber K.","von Delft F.","Arrowsmith C.H.","Edwards A.","Bountra C."]}}]} |
| Chain | Residue | Details |
