6S59
Structure of ovine transhydrogenase in the apo state
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue PC1 A 1101 |
| Chain | Residue |
| A | TYR470 |
| A | TRP474 |
| A | ILE828 |
| A | TYR831 |
| A | PC11102 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PC1 A 1102 |
| Chain | Residue |
| A | PC11101 |
| B | LEU586 |
| B | ALA593 |
| A | TYR436 |
| A | PHE462 |
| A | ILE467 |
| A | TYR470 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PC1 A 1103 |
| Chain | Residue |
| A | TYR798 |
| A | TYR831 |
| A | CYS834 |
| A | ARG839 |
| A | SER840 |
| A | LEU841 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue PC1 A 1104 |
| Chain | Residue |
| A | GLN536 |
| A | ASN552 |
| A | MET609 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue PC1 B 1101 |
| Chain | Residue |
| B | PHE462 |
| B | TYR470 |
| B | TRP474 |
| B | TRP801 |
| B | SER824 |
| B | TYR831 |
| B | PC11102 |
| B | PC11103 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue PC1 B 1102 |
| Chain | Residue |
| A | LEU586 |
| B | TYR436 |
| B | TYR470 |
| B | HIS471 |
| B | PC11101 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PC1 B 1103 |
| Chain | Residue |
| B | TYR798 |
| B | TYR831 |
| B | SER840 |
| B | PC11101 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue PC1 B 1104 |
| Chain | Residue |
| B | GLN536 |
| B | ASP540 |
| B | ASN552 |
| B | ALA559 |
Functional Information from PROSITE/UniProt
| site_id | PS00836 |
| Number of Residues | 27 |
| Details | ALADH_PNT_1 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. GVPkEifqNEk..RVAlSPaGVqaLvKqG |
| Chain | Residue | Details |
| A | GLY17-GLY43 |
| site_id | PS00837 |
| Number of Residues | 26 |
| Details | ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. IVGGGvAGlaSagaAkSMGAiVrgfD |
| Chain | Residue | Details |
| A | ILE189-ASP214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 550 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"UniProtKB","id":"P11024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P11024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31462775","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6QTI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QUE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31462775","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6QUE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P07001","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13423","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13423","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q61941","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
