6S40
Fragment AZ-001 binding at the p53pT387/14-3-3 sigma interface and additional sites
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0001836 | biological_process | release of cytochrome c from mitochondria |
A | 0003334 | biological_process | keratinocyte development |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006469 | biological_process | negative regulation of protein kinase activity |
A | 0006611 | biological_process | protein export from nucleus |
A | 0007165 | biological_process | signal transduction |
A | 0008104 | biological_process | protein localization |
A | 0008426 | molecular_function | protein kinase C inhibitor activity |
A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
A | 0010482 | biological_process | regulation of epidermal cell division |
A | 0010737 | biological_process | protein kinase A signaling |
A | 0010839 | biological_process | negative regulation of keratinocyte proliferation |
A | 0019901 | molecular_function | protein kinase binding |
A | 0022407 | biological_process | regulation of cell-cell adhesion |
A | 0030216 | biological_process | keratinocyte differentiation |
A | 0030307 | biological_process | positive regulation of cell growth |
A | 0031424 | biological_process | keratinization |
A | 0032880 | biological_process | regulation of protein localization |
A | 0042802 | molecular_function | identical protein binding |
A | 0043588 | biological_process | skin development |
A | 0043616 | biological_process | keratinocyte proliferation |
A | 0045296 | molecular_function | cadherin binding |
A | 0045606 | biological_process | positive regulation of epidermal cell differentiation |
A | 0045785 | biological_process | positive regulation of cell adhesion |
A | 0045824 | biological_process | negative regulation of innate immune response |
A | 0046827 | biological_process | positive regulation of protein export from nucleus |
A | 0050815 | molecular_function | phosphoserine residue binding |
A | 0051219 | molecular_function | phosphoprotein binding |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0061436 | biological_process | establishment of skin barrier |
A | 0070062 | cellular_component | extracellular exosome |
A | 0072089 | biological_process | stem cell proliferation |
A | 0140311 | molecular_function | protein sequestering activity |
A | 1903077 | biological_process | negative regulation of protein localization to plasma membrane |
A | 1903829 | biological_process | positive regulation of protein localization |
A | 2000647 | biological_process | negative regulation of stem cell proliferation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue MG A 301 |
Chain | Residue |
A | GLU35 |
A | GLU110 |
A | GLU188 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue MG A 302 |
Chain | Residue |
A | GLU89 |
A | HOH430 |
A | HOH479 |
site_id | AC3 |
Number of Residues | 1 |
Details | binding site for residue CL A 303 |
Chain | Residue |
A | LYS9 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue MG A 304 |
Chain | Residue |
A | HOH429 |
A | HOH429 |
A | GLU2 |
A | GLU2 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue MG A 305 |
Chain | Residue |
A | GLY-4 |
A | ALA-3 |
A | MET-2 |
A | GLU31 |
A | HOH420 |
A | HOH476 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue KTW A 306 |
Chain | Residue |
A | GLU14 |
A | GLU39 |
A | ASN42 |
A | LEU43 |
A | KTW308 |
A | HOH437 |
A | HOH512 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue KTW A 307 |
Chain | Residue |
A | GLN93 |
A | ASP97 |
A | LEU100 |
A | TYR128 |
A | LEU131 |
A | HOH567 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue KTW A 308 |
Chain | Residue |
A | KTW306 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue KTW A 309 |
Chain | Residue |
A | GLU34 |
A | LYS195 |
A | ASP199 |
A | ARG224 |
A | THR231 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue GOL A 310 |
Chain | Residue |
A | GLU110 |
A | PHE198 |
A | THR217 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue CA A 311 |
Chain | Residue |
A | ARG60 |
A | GLU133 |
A | HOH582 |
A | HOH600 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287 |
Chain | Residue | Details |
P | LYS382 | |
A | ARG129 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CK2, CDK2 and NUAK1 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:22214662 |
Chain | Residue | Details |
P | SER392 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37 |
Chain | Residue | Details |
P | LYS386 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
A | SER248 |