Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0046777 | biological_process | protein autophosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue KRK A 501 |
| Chain | Residue |
| A | ILE165 |
| A | LEU294 |
| A | VAL306 |
| A | HOH677 |
| A | GLY166 |
| A | PHE170 |
| A | VAL173 |
| A | ALA186 |
| A | LYS188 |
| A | PHE238 |
| A | GLU239 |
| A | LEU241 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ASN198 |
| A | GLN199 |
| A | GLN199 |
| A | ILE202 |
| A | ILE202 |
| A | TYR319 |
| A | TYR319 |
| A | HOH610 |
| A | HOH610 |
| A | HOH639 |
| A | HOH639 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | THR466 |
| A | ARG467 |
| A | ILE468 |
| A | GLN469 |
| A | TYR472 |
| A | HOH778 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ALA382 |
| A | HIS383 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | VAL376 |
| A | LYS422 |
| A | LEU423 |
| A | HIS424 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 506 |
| Chain | Residue |
| A | ASN365 |
| A | GLU366 |
| A | VAL367 |
| A | LYS393 |
| A | SO4511 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | MET336 |
| A | ASP463 |
| A | PRO464 |
| A | LYS465 |
| A | HOH603 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | TYR243 |
| A | ASN251 |
| A | LEU274 |
| A | HOH625 |
| A | HOH652 |
| A | HOH774 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 509 |
| Chain | Residue |
| A | SER169 |
| A | LYS193 |
| A | LYS194 |
| A | HOH613 |
| A | HOH675 |
| A | HOH701 |
| A | HOH745 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 510 |
| Chain | Residue |
| A | ASN144 |
| A | TYR145 |
| A | SER169 |
| A | LYS191 |
| A | LYS193 |
| A | HOH641 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 511 |
| Chain | Residue |
| A | ASN232 |
| A | ARG325 |
| A | ARG328 |
| A | GLU366 |
| A | DMS506 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 512 |
| Chain | Residue |
| A | LYS264 |
| A | ARG300 |
| A | SER301 |
| A | HOH805 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydrveqew..........VAIK |
| Chain | Residue | Details |
| A | ILE165-LYS188 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL |
| Chain | Residue | Details |
| A | ILE283-LEU295 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q63470","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000269"}]} |
