6S0J

Structure of Zika virus NS3 helicase in complex with ADP-MgF3(H2O)-

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue KQB A 701

Chain	Residue
A	PRO196
A	HOH817
A	HOH832
A	HOH857
A	HOH871
A	HOH967
A	GLY197
A	LYS200
A	GLU286
A	GLY415
A	ARG459
A	ARG462
A	MG702
A	ADP703

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site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 702

Chain	Residue
A	THR201
A	KQB701
A	ADP703
A	HOH817
A	HOH871
A	HOH967

---

site_id	AC3
Number of Residues	18
Details	binding site for residue ADP A 703

Chain	Residue
A	GLY197
A	ALA198
A	GLY199
A	LYS200
A	THR201
A	ARG202
A	ASN330
A	ASN417
A	ARG462
A	KQB701
A	MG702
A	HOH817
A	HOH823
A	HOH841
A	HOH871
A	HOH912
A	HOH924
A	HOH1041

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU194

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG456
A	ARG459

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
A	ARG617

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
A	LYS389

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