6S0H

Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed doripenem

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
B	0008270	molecular_function	zinc ion binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS77
A	HIS79
A	HIS139
A	KQ8310

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	ASP81
A	CYS158
A	HIS197
A	KQ8310

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 303

Chain	Residue
A	ILE70
A	SER93
B	LYS127
A	GLU69

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 305

Chain	Residue
A	SER99
A	LEU101
A	TYR134
A	ASP142
A	LEU144

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 306

Chain	Residue
A	THR42
A	ASP43
A	GLY67
A	GLU69

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 308

Chain	Residue
A	GLU10
A	HIS34
A	SER198
A	GLU199
A	LYS200

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO A 309

Chain	Residue
A	ASN128

---

site_id	AC8
Number of Residues	15
Details	binding site for residue KQ8 A 310

Chain	Residue
A	TRP28
A	VAL30
A	THR32
A	PHE51
A	HIS77
A	HIS79
A	ASP81
A	HIS139
A	CYS158
A	LYS161
A	LEU165
A	ASN167
A	HIS197
A	ZN301
A	ZN302

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO B 401

Chain	Residue
A	GLN113
B	SER119
B	GLU120

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 402

Chain	Residue
B	HIS77
B	HIS79
B	HIS139
B	KQ8404

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN B 403

Chain	Residue
B	ASP81
B	CYS158
B	HIS197
B	KQ8404

---

site_id	AD3
Number of Residues	19
Details	binding site for residue KQ8 B 404

Chain	Residue
B	VAL25
B	TRP28
B	VAL30
B	VAL31
B	THR32
B	PHE51
B	HIS77
B	HIS79
B	SER80
B	ASP81
B	HIS139
B	CYS158
B	LYS161
B	LEU165
B	GLY166
B	ASN167
B	HIS197
B	ZN402
B	ZN403

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	20
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. IsSHfHSDstGGiewlnsq.S

Chain	Residue	Details
A	ILE74-SER93

---

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PeskILfGgCFIK

Chain	Residue	Details
A	PRO149-LYS161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32205343","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2020","submissionDatabase":"PDB data bank","title":"Structure of IMP-13 metallo-beta-lactamase complexed with citrate anion.","authors":["Zak K.M.","Zhou R.X.","Softley C.A.","Bostock M.J.","Sattler M.","Popowicz G.M."]}},{"source":"PDB","id":"6R73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6R79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RZR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RZS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6S0H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6YI4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P52699","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32205343","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---