6RZ9

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004974	molecular_function	leukotriene receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue KO5 A 2001

Chain	Residue
A	LYS37
A	MET201
A	ASN202
A	ARG267
A	LEU271
A	HIS284
A	OLC2014
A	HOH2108
A	TYR119
A	TYR123
A	TYR127
A	SER169
A	SER170
A	LEU188
A	LEU190
A	LYS194

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CLR A 2002

Chain	Residue
A	SER218
A	LEU261
A	THR265

---

site_id	AC3
Number of Residues	3
Details	binding site for residue 1PE A 2003

Chain	Residue
A	ARG282
A	GLU1004
A	LEU1106

---

site_id	AC4
Number of Residues	5
Details	binding site for residue OLC A 2004

Chain	Residue
A	PHE36
A	GLU39
A	PHE40
A	OLC2005
A	OLC2006

---

site_id	AC5
Number of Residues	4
Details	binding site for residue OLC A 2005

Chain	Residue
A	PHE36
A	PHE40
A	LYS285
A	OLC2004

---

site_id	AC6
Number of Residues	3
Details	binding site for residue OLC A 2006

Chain	Residue
A	ASP96
A	ARG100
A	OLC2004

---

site_id	AC7
Number of Residues	3
Details	binding site for residue OLC A 2007

Chain	Residue
A	LEU54
A	GLY55
A	CYS299

---

site_id	AC8
Number of Residues	2
Details	binding site for residue OLC A 2008

Chain	Residue
A	CYS220
A	OLA2018

---

site_id	AC9
Number of Residues	2
Details	binding site for residue OLC A 2009

Chain	Residue
A	SER218
A	ARG226

---

site_id	AD1
Number of Residues	1
Details	binding site for residue OLC A 2010

Chain	Residue
A	TYR61

---

site_id	AD2
Number of Residues	1
Details	binding site for residue OLC A 2011

Chain	Residue
A	ASP96

---

site_id	AD3
Number of Residues	7
Details	binding site for residue OLC A 2012

Chain	Residue
A	LEU228
A	GLU232
A	LEU246
A	THR247
A	ILE250
A	LEU1106
A	OLA2023

---

site_id	AD4
Number of Residues	2
Details	binding site for residue OLC A 2013

Chain	Residue
A	TYR221
A	OLA2020

---

site_id	AD5
Number of Residues	6
Details	binding site for residue OLC A 2014

Chain	Residue
A	TYR127
A	LEU165
A	SER169
A	ILE204
A	VAL208
A	KO52001

---

site_id	AD6
Number of Residues	2
Details	binding site for residue OLC A 2015

Chain	Residue
A	ILE105
A	PHE106

---

site_id	AD7
Number of Residues	3
Details	binding site for residue OLA A 2017

Chain	Residue
A	TYR203
A	THR268
A	HOH2102

---

site_id	AD8
Number of Residues	3
Details	binding site for residue OLA A 2018

Chain	Residue
A	TYR137
A	PHE215
A	OLC2008

---

site_id	AD9
Number of Residues	1
Details	binding site for residue OLA A 2019

Chain	Residue
A	ARG226

---

site_id	AE1
Number of Residues	6
Details	binding site for residue OLA A 2020

Chain	Residue
A	TYR221
A	LEU229
A	GLU232
A	PRO262
A	OLC2013
A	HOH2101

---

site_id	AE2
Number of Residues	2
Details	binding site for residue OLA A 2021

Chain	Residue
A	LEU64
A	LEU85

---

site_id	AE3
Number of Residues	4
Details	binding site for residue OLA A 2022

Chain	Residue
A	SER83
A	LEU86
A	TRP163
A	MET167

---

site_id	AE4
Number of Residues	1
Details	binding site for residue OLA A 2023

Chain	Residue
A	OLC2012

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	ILE43-PHE63

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LEU64-SER72
A	ARG145-ARG153

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	VAL73-PHE93

---

site_id	SWS_FT_FI4
Number of Residues	77
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	ARG94-TYR123
A	ASP175-ILE204
A	ARG267-ALA286

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	SER124-PHE144

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	SER154-LEU174

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	ALA205-ILE225

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	LEU246-LEU266

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	LEU287-PHE307

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN20
A	ASN26
A	ASN30
A	ASN181

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

---