6RYO

Bacterial membrane enzyme structure by the in meso method at 1.9 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue OLC A 201

Chain	Residue
A	VAL17
A	VAL94
A	LEU98
A	ILE134
A	SER137
A	OLC202
A	OLC204
A	OLC205
B	OLC101

---

site_id	AC2
Number of Residues	5
Details	binding site for residue OLC A 202

Chain	Residue
A	LEU90
A	PHE91
A	VAL94
A	OLC201
A	7PE215

---

site_id	AC3
Number of Residues	6
Details	binding site for residue OLC A 203

Chain	Residue
A	ALA14
A	ILE19
A	PHE82
A	SER97
A	PHE100
A	7PE214

---

site_id	AC4
Number of Residues	8
Details	binding site for residue OLC A 204

Chain	Residue
A	THR9
A	LEU12
A	PHE16
A	PHE20
A	LEU60
A	SER61
A	PHE66
A	OLC201

---

site_id	AC5
Number of Residues	5
Details	binding site for residue OLC A 205

Chain	Residue
A	ILE28
A	PHE38
A	LEU45
A	OLC201
B	OLC101

---

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL A 206

Chain	Residue
A	ILE83
A	LYS84
A	TYR127
A	ASP128

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GOL A 207

Chain	Residue
A	PHE129
A	PRO130
B	7PE102

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL A 208

Chain	Residue
A	SER37
A	LYS152
A	7PE210
A	7PE216

---

site_id	AC9
Number of Residues	4
Details	binding site for residue 7PE A 209

Chain	Residue
A	ILE74
A	LEU78
A	PHE81
A	7PE214

---

site_id	AD1
Number of Residues	4
Details	binding site for residue 7PE A 210

Chain	Residue
A	PHE44
A	ASN89
A	ALA149
A	GOL208

---

site_id	AD2
Number of Residues	2
Details	binding site for residue 7PE A 211

Chain	Residue
A	THR140
B	MLE1

---

site_id	AD3
Number of Residues	2
Details	binding site for residue 7PE A 212

Chain	Residue
A	ASP121
A	TYR127

---

site_id	AD4
Number of Residues	7
Details	binding site for residue 7PE A 213

Chain	Residue
A	LYS25
A	ALA29
A	ARG51
A	THR113
A	GLU115
A	VAL117
A	HOH301

---

site_id	AD5
Number of Residues	6
Details	binding site for residue 7PE A 214

Chain	Residue
A	ILE19
A	GLN22
A	VAL23
A	TYR26
A	OLC203
A	7PE209

---

site_id	AD6
Number of Residues	7
Details	binding site for residue 7PE A 215

Chain	Residue
A	HIS2
A	ILE34
A	PHE44
A	TYR88
A	LEU90
A	PHE91
A	OLC202

---

site_id	AD7
Number of Residues	7
Details	binding site for residue 7PE A 216

Chain	Residue
A	VAL111
A	LEU112
A	LEU150
A	LEU151
A	LYS152
A	THR154
A	GOL208

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN A 217

Chain	Residue
A	HIS0
A	HIS2
A	HIS43
A	GLU115

---

site_id	AD9
Number of Residues	3
Details	binding site for residue 7PE A 218

Chain	Residue
A	THR65
A	PHE68
A	GOL220

---

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL A 219

Chain	Residue
A	GLY62
A	LYS63
A	MET64
A	THR65
A	GOL220
A	HOH303

---

site_id	AE2
Number of Residues	4
Details	binding site for residue GOL A 220

Chain	Residue
A	HOH303
A	THR65
A	7PE218
A	GOL219

---

site_id	AE3
Number of Residues	13
Details	binding site for residue OLC B 101

Chain	Residue
A	LEU45
A	ASN52
A	ASP118
A	PHE129
A	PRO130
A	ILE131
A	PHE132
A	THR140
A	OLC201
A	OLC205
B	IIL2
B	SER3
B	ALO4

---

site_id	AE4
Number of Residues	2
Details	binding site for residue 7PE B 102

Chain	Residue
A	TRP57
A	GOL207

---

site_id	AE5
Number of Residues	19
Details	binding site for Ligand residues ALO B 4 through SER B 3 bound to SER B 3

Chain	Residue
A	GLY8
A	LEU12
A	ASN52
A	GLY54
A	TRP57
A	LEU60
A	PHE67
A	THR71
A	ILE74
A	ASN106
A	ARG110
A	VAL116
A	ASP118
A	ASN133
A	ASP136
A	LEU139
A	7PE211
A	HOH306
B	OLC101

---

Functional Information from PROSITE/UniProt

site_id	PS00855
Number of Residues	13
Details	SPASE_II Signal peptidases II signature. LfAGALGNFIDRV

Chain	Residue	Details
A	LEU99-VAL111

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_00161","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00161","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---