6RXS

Crystal structure of CobB Ac3(A76G,Y92A, I131L, V187Y) in complex with H4K16-Acetyl peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0036054	molecular_function	protein-malonyllysine demalonylase activity
A	0036055	molecular_function	protein-succinyllysine desuccinylase activity
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS155
A	CYS174
A	CYS176
A	CYS177

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site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 302

Chain	Residue
A	HOH470
A	VAL143
A	ILE144
A	HIS145
A	GLY196
A	HOH420

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 303

Chain	Residue
A	ARG154
A	PRO185
A	HIS186
A	TYR187
A	GLU192
A	HOH445

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL B 101

Chain	Residue
A	GLN260
A	GLU264
B	ARG17

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Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	DNA_BIND:

Chain	Residue	Details
B	ALY16-LYS20

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
B	LYS12
A	GLN129
A	GLY214
A	ASN240
A	ALA258

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393

Chain	Residue	Details
B	ALY16
A	ARG95

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793

Chain	Residue	Details
B	LYS20
A	CYS174

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447

Chain	Residue	Details
B	LYS12

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS20

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