6RWZ

Structure of Zika virus NS3 helicase in complex with ADP-BeF3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN A 701

Chain	Residue
A	THR201
A	GLU286
A	BEF702
A	ADP703
A	HOH877
A	HOH904

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site_id	AC2
Number of Residues	12
Details	binding site for residue BEF A 702

Chain	Residue
A	ALA317
A	ARG459
A	ARG462
A	MN701
A	ADP703
A	HOH877
A	HOH904
A	HOH960
A	HOH1034
A	PRO196
A	LYS200
A	GLU286

---

site_id	AC3
Number of Residues	16
Details	binding site for residue ADP A 703

Chain	Residue
A	GLY197
A	ALA198
A	GLY199
A	LYS200
A	THR201
A	ARG202
A	ASN330
A	ARG462
A	MN701
A	BEF702
A	HOH808
A	HOH824
A	HOH877
A	HOH904
A	HOH918
A	HOH932

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU194

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG456
A	ARG459

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
A	ARG617

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
A	LYS389

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