6RWH
Fragment AZ-007 binding at a primary and secondary binding site of the the p53pT387/14-3-3 sigma complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001836 | biological_process | release of cytochrome c from mitochondria |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006611 | biological_process | protein export from nucleus |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | intracellular protein localization |
| A | 0008426 | molecular_function | protein kinase C inhibitor activity |
| A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
| A | 0010482 | biological_process | regulation of epidermal cell division |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022407 | biological_process | regulation of cell-cell adhesion |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0032880 | biological_process | regulation of protein localization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0045606 | biological_process | positive regulation of epidermal cell differentiation |
| A | 0045785 | biological_process | positive regulation of cell adhesion |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0046827 | biological_process | positive regulation of protein export from nucleus |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0061436 | biological_process | establishment of skin barrier |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 0141156 | biological_process | cAMP/PKA signal transduction |
| A | 1903077 | biological_process | negative regulation of protein localization to plasma membrane |
| A | 1903829 | biological_process | positive regulation of protein localization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue KLB A 301 |
| Chain | Residue |
| A | GLU14 |
| A | ASN42 |
| A | LEU43 |
| A | HOH451 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue KLB A 302 |
| Chain | Residue |
| A | ASP97 |
| A | TYR128 |
| A | ASP139 |
| A | ILE143 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 303 |
| Chain | Residue |
| A | HOH552 |
| A | HOH557 |
| A | LYS9 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 304 |
| Chain | Residue |
| A | GLU35 |
| A | GLU110 |
| A | GLU188 |
| A | HOH473 |
| A | HOH524 |
| A | HOH545 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG P 401 |
| Chain | Residue |
| P | ASP391 |
| P | ASP393 |
| P | HOH502 |
| P | HOH504 |
| P | HOH505 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with phosphoserine on interacting protein"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine; by KMT5A; alternate","evidences":[{"source":"PubMed","id":"17707234","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20870725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22864287","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"11124955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22214662","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"1999","firstPage":"6462","lastPage":"6471","volume":"18","journal":"EMBO J.","title":"Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.","authors":["Gostissa M.","Hengstermann A.","Fogal V.","Sandy P.","Schwarz S.E.","Scheffner M.","Del Sal G."]}}]} |
| Chain | Residue | Details |
