6RV4

Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005252	molecular_function	open rectifier potassium channel activity
A	0005267	molecular_function	potassium channel activity
A	0016020	cellular_component	membrane
A	0071805	biological_process	potassium ion transmembrane transport
B	0005252	molecular_function	open rectifier potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0016020	cellular_component	membrane
B	0071805	biological_process	potassium ion transmembrane transport
C	0005252	molecular_function	open rectifier potassium channel activity
C	0005267	molecular_function	potassium channel activity
C	0016020	cellular_component	membrane
C	0071805	biological_process	potassium ion transmembrane transport
D	0005252	molecular_function	open rectifier potassium channel activity
D	0005267	molecular_function	potassium channel activity
D	0016020	cellular_component	membrane
D	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue K A 302

Chain	Residue
A	ILE94
B	GLY201
A	GLY95
A	ILE200
A	GLY201
A	K303
A	K309
B	ILE94
B	GLY95
B	ILE200

---

site_id	AC2
Number of Residues	10
Details	binding site for residue K A 303

Chain	Residue
A	THR93
A	ILE94
A	THR199
A	ILE200
A	K302
A	K304
B	THR93
B	ILE94
B	THR199
B	ILE200

---

site_id	AC3
Number of Residues	5
Details	binding site for residue K A 304

Chain	Residue
A	THR93
A	THR199
A	K303
B	THR93
B	THR199

---

site_id	AC4
Number of Residues	5
Details	binding site for residue Y01 A 305

Chain	Residue
A	ARG3
A	PHE238
A	PHE246
B	LEU115
B	PRO119

---

site_id	AC5
Number of Residues	5
Details	binding site for residue Y01 A 306

Chain	Residue
A	ARG79
A	PHE80
A	ALA81
A	GLN215
B	PHE16

---

site_id	AC6
Number of Residues	20
Details	binding site for residue KKZ A 307

Chain	Residue
A	THR92
A	ILE118
A	LEU122
A	PHE125
A	LEU197
A	THR198
A	THR199
A	LEU232
A	ILE235
A	LEU239
B	THR92
B	THR93
B	ILE118
B	LEU122
B	LEU197
B	THR198
B	THR199
B	LEU232
B	ILE235
B	LEU239

---

site_id	AC7
Number of Residues	3
Details	binding site for residue PC1 A 308

Chain	Residue
A	PHE112
A	SER169
A	HIS180

---

site_id	AC8
Number of Residues	9
Details	binding site for residue K A 309

Chain	Residue
A	GLY95
A	TYR96
A	GLY201
A	PHE202
A	K302
B	GLY95
B	TYR96
B	GLY201
B	PHE202

---

site_id	AC9
Number of Residues	5
Details	binding site for residue Y01 A 301

Chain	Residue
A	LEU115
B	ARG3
B	ARG7
B	PHE238
B	PHE246

---

site_id	AD1
Number of Residues	5
Details	binding site for residue Y01 B 302

Chain	Residue
A	PHE16
B	ARG79
B	PHE80
B	ALA81
B	GLN215

---

site_id	AD2
Number of Residues	2
Details	binding site for residue PC1 B 303

Chain	Residue
B	SER169
B	HIS180

---

site_id	AD3
Number of Residues	10
Details	binding site for residue K C 302

Chain	Residue
C	ILE94
C	GLY95
C	ILE200
C	GLY201
C	K303
C	K307
D	ILE94
D	GLY95
D	ILE200
D	GLY201

---

site_id	AD4
Number of Residues	10
Details	binding site for residue K C 303

Chain	Residue
C	THR93
C	ILE94
C	THR199
C	ILE200
C	K302
C	K304
D	THR93
D	ILE94
D	THR199
D	ILE200

---

site_id	AD5
Number of Residues	5
Details	binding site for residue K C 304

Chain	Residue
C	THR93
C	THR199
C	K303
D	THR93
D	THR199

---

site_id	AD6
Number of Residues	3
Details	binding site for residue PC1 C 305

Chain	Residue
C	PHE112
C	SER169
C	HIS180

---

site_id	AD7
Number of Residues	5
Details	binding site for residue PC1 C 306

Chain	Residue
C	ALA28
D	PHE112
D	SER169
D	ALA176
D	HIS180

---

site_id	AD8
Number of Residues	9
Details	binding site for residue K C 307

Chain	Residue
C	GLY95
C	TYR96
C	GLY201
C	PHE202
C	K302
D	GLY95
D	TYR96
D	GLY201
D	PHE202

---

site_id	AD9
Number of Residues	4
Details	binding site for residue Y01 C 308

Chain	Residue
C	PHE238
C	PHE246
D	LEU115
D	PRO119

---

site_id	AE1
Number of Residues	20
Details	binding site for residue KKZ D 302

Chain	Residue
C	THR92
C	ILE118
C	LEU122
C	PHE125
C	LEU197
C	THR198
C	THR199
C	LEU232
C	ILE235
C	LEU239
D	THR92
D	THR93
D	ILE118
D	LEU122
D	LEU197
D	THR198
D	THR199
D	LEU232
D	ILE235
D	LEU239

---

site_id	AE2
Number of Residues	4
Details	binding site for residue Y01 D 303

Chain	Residue
C	LEU115
D	ARG3
D	PHE238
D	PHE246

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	320
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	92
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	92
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Region: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"26919430","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Region: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"26919430","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Region: {"description":"X-gate","evidences":[{"source":"PubMed","id":"32499642","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32499642","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RV2","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6RV4","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---