Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue TOP A 301 |
| Chain | Residue |
| A | ASP101 |
| A | NDP302 |
| A | HOH469 |
| A | HOH478 |
| A | HOH526 |
| A | PHE105 |
| A | SER123 |
| A | ILE168 |
| A | TYR174 |
| A | ILE243 |
| A | ALA244 |
| A | ALA245 |
| A | MET258 |
| site_id | AC2 |
| Number of Residues | 32 |
| Details | binding site for residue NDP A 302 |
| Chain | Residue |
| A | GLY117 |
| A | ARG118 |
| A | HIS119 |
| A | THR120 |
| A | LEU136 |
| A | SER137 |
| A | SER138 |
| A | LYS150 |
| A | ILE168 |
| A | GLY170 |
| A | GLY171 |
| A | ARG172 |
| A | VAL173 |
| A | TYR174 |
| A | GLN176 |
| A | ALA244 |
| A | ALA245 |
| A | ILE252 |
| A | GLY253 |
| A | ASN256 |
| A | ALA257 |
| A | MET258 |
| A | TRP260 |
| A | TOP301 |
| A | CL304 |
| A | HOH444 |
| A | HOH451 |
| A | HOH456 |
| A | HOH511 |
| A | HOH541 |
| A | HOH554 |
| A | HOH558 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | TRP47 |
| A | GLY125 |
| A | ARG145 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | VAL152 |
| A | NDP302 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 305 |
| Chain | Residue |
| A | SER33 |
| A | HOH479 |
| A | HOH568 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue PG4 A 306 |
| Chain | Residue |
| A | PRO163 |
| A | GLU164 |
| A | LYS183 |
| A | GLY238 |
| A | GLN267 |
| A | GLY268 |
| A | GLN270 |
| A | HOH518 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 307 |
| Chain | Residue |
| A | LEU178 |
| A | PRO179 |
| A | TYR202 |
| A | GLU203 |
| A | TRP207 |
| A | ARG232 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ILE243 | |
| A | ASP101 | |
| A | ARG126 | |
| A | ARG131 | |
| A | THR187 | |
| Chain | Residue | Details |
| A | ALA245 | |
| A | VAL251 | |
| A | HIS119 | |
| A | SER137 | |
| A | LYS150 | |
| A | GLY169 | |
