6RS1

Dipeptide Gly-Pro binds to a glycolytic enzyme fructose bisphosphate aldolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003729	molecular_function	mRNA binding
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0009506	cellular_component	plasmodesma
A	0016829	molecular_function	lyase activity
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0031930	biological_process	mitochondria-nucleus signaling pathway
A	0071456	biological_process	cellular response to hypoxia
A	1901149	molecular_function	salicylic acid binding
B	0003729	molecular_function	mRNA binding
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0009506	cellular_component	plasmodesma
B	0016829	molecular_function	lyase activity
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0031930	biological_process	mitochondria-nucleus signaling pathway
B	0071456	biological_process	cellular response to hypoxia
B	1901149	molecular_function	salicylic acid binding
C	0003729	molecular_function	mRNA binding
C	0004332	molecular_function	fructose-bisphosphate aldolase activity
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0009506	cellular_component	plasmodesma
C	0016829	molecular_function	lyase activity
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0031930	biological_process	mitochondria-nucleus signaling pathway
C	0071456	biological_process	cellular response to hypoxia
C	1901149	molecular_function	salicylic acid binding
D	0003729	molecular_function	mRNA binding
D	0004332	molecular_function	fructose-bisphosphate aldolase activity
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0009506	cellular_component	plasmodesma
D	0016829	molecular_function	lyase activity
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0031930	biological_process	mitochondria-nucleus signaling pathway
D	0071456	biological_process	cellular response to hypoxia
D	1901149	molecular_function	salicylic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 401

Chain	Residue
A	LYS225
A	LEU265
A	SER266
A	GLY267
A	SER295
A	GLY297
A	ARG298
A	HOH559

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG203
A	ALA207
A	HOH545
A	HOH585
C	GLN156
D	LYS210
D	ASP214
A	GLN156

---

site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 B 401

Chain	Residue
A	GLN156
B	LYS210
B	ASP214
B	HOH505
B	HOH582
C	GLN156
C	ILE159
C	ARG203
C	ALA207

---

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 B 402

Chain	Residue
B	GLN156
B	ARG203
B	ALA207
B	HOH508
B	HOH519
C	LYS210
C	ASP214
D	GLN156
D	HOH503

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 B 403

Chain	Residue
B	ASP30
B	GLU31
B	SER32
B	THR35
B	LYS103
B	HOH583

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 C 401

Chain	Residue
C	ASP30
C	GLU31
C	SER32
C	THR35
C	LYS103
C	HOH605

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 C 402

Chain	Residue
C	GLU11
C	LYS94
C	ARG139

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 D 401

Chain	Residue
D	SER32
D	THR35
D	LYS103

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 D 402

Chain	Residue
A	LYS210
A	ASP214
B	GLN156
D	GLN156
D	ARG203
D	HOH513
D	HOH516

---

Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGtLLKPN

Chain	Residue	Details
A	VAL217-ASN227

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Schiff-base intermediate with dihydroxyacetone-P","evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"S-glutathionyl cysteine; transient","evidences":[{"source":"PubMed","id":"21782461","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"S-nitrosocysteine; transient; alternate","evidences":[{"source":"PubMed","id":"21782461","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---