6RRW
GOLGI ALPHA-MANNOSIDASE II in complex with (2R,3R,4R,5S)-1-(5-{[4-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)benzyl]oxy}pentyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004559 | molecular_function | alpha-mannosidase activity |
| A | 0004572 | molecular_function | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005795 | cellular_component | Golgi stack |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006486 | biological_process | protein glycosylation |
| A | 0006491 | biological_process | N-glycan processing |
| A | 0015923 | molecular_function | mannosidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016063 | biological_process | rhodopsin biosynthetic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0035010 | biological_process | encapsulation of foreign target |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue KG5 A 1101 |
| Chain | Residue |
| A | HIS90 |
| A | TYR727 |
| A | ARG876 |
| A | GLY877 |
| A | ZN1102 |
| A | HOH1226 |
| A | ASP92 |
| A | TRP95 |
| A | ASP204 |
| A | PHE206 |
| A | ARG228 |
| A | ASP341 |
| A | HIS471 |
| A | ASP472 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1102 |
| Chain | Residue |
| A | HIS90 |
| A | ASP92 |
| A | ASP204 |
| A | HIS471 |
| A | KG51101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP204 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS90 | |
| A | ASP92 | |
| A | ASP204 | |
| A | HIS471 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 793 |
| Chain | Residue | Details |
| A | HIS90 | metal ligand |
| A | ASP92 | metal ligand |
| A | ASP204 | covalently attached, metal ligand, nucleofuge, nucleophile |
| A | ASP341 | activator, increase nucleophilicity, proton acceptor, proton donor |
| A | HIS471 | metal ligand |
