6RRN
GOLGI ALPHA-MANNOSIDASE II in complex with pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004559 | molecular_function | alpha-mannosidase activity |
| A | 0004572 | molecular_function | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005795 | cellular_component | Golgi stack |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006486 | biological_process | obsolete protein glycosylation |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0006491 | biological_process | N-glycan processing |
| A | 0015923 | molecular_function | mannosidase activity |
| A | 0016063 | biological_process | rhodopsin biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0035010 | biological_process | encapsulation of foreign target |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1904381 | biological_process | Golgi apparatus N-glycan mannose trimming |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1101 |
| Chain | Residue |
| A | ARG176 |
| A | ASN177 |
| A | LEU180 |
| A | MET433 |
| A | VAL436 |
| A | HOH1245 |
| A | HOH1340 |
| A | HOH1525 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1102 |
| Chain | Residue |
| A | TYR267 |
| A | HIS273 |
| A | HOH1258 |
| A | HOH1455 |
| A | HOH1465 |
| A | LYS63 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1103 |
| Chain | Residue |
| A | ASP42 |
| A | VAL43 |
| A | GLN44 |
| A | ARG51 |
| A | HOH1297 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue SIN A 1104 |
| Chain | Residue |
| A | SER534 |
| A | ARG540 |
| A | TYR572 |
| A | ARG617 |
| A | GLN766 |
| A | HOH1274 |
| A | HOH1376 |
| A | HOH1386 |
| A | HOH1565 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1105 |
| Chain | Residue |
| A | ARG964 |
| A | GLN973 |
| A | HIS1043 |
| A | HOH1296 |
| A | HOH1530 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue KFT A 1106 |
| Chain | Residue |
| A | HIS90 |
| A | ASP92 |
| A | TRP95 |
| A | ASP204 |
| A | PHE206 |
| A | ARG228 |
| A | TYR269 |
| A | ASP341 |
| A | HIS471 |
| A | ASP472 |
| A | TYR727 |
| A | ARG876 |
| A | GLY877 |
| A | ZN1110 |
| A | HOH1464 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 1107 |
| Chain | Residue |
| A | MET45 |
| A | LEU46 |
| A | TYR49 |
| A | ASP403 |
| A | ILE814 |
| A | LYS815 |
| A | ARG816 |
| A | HOH1635 |
| A | HOH1660 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1108 |
| Chain | Residue |
| A | HIS230 |
| A | THR406 |
| A | ALA826 |
| A | TYR829 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1109 |
| Chain | Residue |
| A | ARG228 |
| A | TYR267 |
| A | ASP409 |
| A | HOH1341 |
| A | HOH1536 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1110 |
| Chain | Residue |
| A | HIS90 |
| A | ASP92 |
| A | ASP204 |
| A | HIS471 |
| A | KFT1106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 793 |
| Chain | Residue | Details |
| A | HIS90 | metal ligand |
| A | ASP92 | metal ligand |
| A | ASP204 | covalently attached, metal ligand, nucleofuge, nucleophile |
| A | ASP341 | activator, increase nucleophilicity, proton acceptor, proton donor |
| A | HIS471 | metal ligand |
