6RQZ
GOLGI ALPHA-MANNOSIDASE II complex with Manno-epi-cyclophellitol aziridine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004559 | molecular_function | alpha-mannosidase activity |
| A | 0004572 | molecular_function | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005795 | cellular_component | Golgi stack |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006486 | biological_process | obsolete protein glycosylation |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0006491 | biological_process | N-glycan processing |
| A | 0015923 | molecular_function | mannosidase activity |
| A | 0016063 | biological_process | rhodopsin biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0035010 | biological_process | encapsulation of foreign target |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1904381 | biological_process | Golgi apparatus N-glycan mannose trimming |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1201 |
| Chain | Residue |
| A | ARG176 |
| A | ASN177 |
| A | MET433 |
| A | VAL436 |
| A | HOH1346 |
| A | HOH1522 |
| A | HOH1688 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1202 |
| Chain | Residue |
| A | HIS273 |
| A | HOH1536 |
| A | HOH1599 |
| A | HOH1617 |
| A | LYS63 |
| A | TYR267 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1203 |
| Chain | Residue |
| A | LEU568 |
| A | ASP570 |
| A | ARG617 |
| A | GLU753 |
| A | HOH1511 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1204 |
| Chain | Residue |
| A | GLU936 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1205 |
| Chain | Residue |
| A | ARG228 |
| A | TYR267 |
| A | ASP409 |
| A | KGH1210 |
| A | HOH1502 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1206 |
| Chain | Residue |
| A | ASP340 |
| A | ASP341 |
| A | ARG343 |
| A | HOH1503 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1207 |
| Chain | Residue |
| A | ARG457 |
| A | ALA496 |
| A | HOH1587 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1208 |
| Chain | Residue |
| A | SER552 |
| A | LYS553 |
| A | HIS554 |
| A | PHE934 |
| A | ASN937 |
| A | HOH1552 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue SIN A 1209 |
| Chain | Residue |
| A | SER534 |
| A | ARG540 |
| A | TYR572 |
| A | ARG617 |
| A | ARG777 |
| A | HOH1355 |
| A | HOH1385 |
| A | HOH1464 |
| A | HOH1861 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue KGH A 1210 |
| Chain | Residue |
| A | HIS90 |
| A | ASP92 |
| A | TRP95 |
| A | ASP204 |
| A | PHE206 |
| A | ARG228 |
| A | TYR269 |
| A | ASP341 |
| A | TRP415 |
| A | HIS471 |
| A | ASP472 |
| A | TYR727 |
| A | ARG876 |
| A | EDO1205 |
| A | ZN1211 |
| A | HOH1351 |
| A | HOH1687 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1211 |
| Chain | Residue |
| A | HIS90 |
| A | ASP92 |
| A | ASP204 |
| A | HIS471 |
| A | KGH1210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 793 |
| Chain | Residue | Details |
| A | HIS90 | metal ligand |
| A | ASP92 | metal ligand |
| A | ASP204 | covalently attached, metal ligand, nucleofuge, nucleophile |
| A | ASP341 | activator, increase nucleophilicity, proton acceptor, proton donor |
| A | HIS471 | metal ligand |
