6ROG

Crystal Structure of the KELCH domain of human KEAP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
X	0008134	molecular_function	transcription factor binding
X	0016567	biological_process	protein ubiquitination
X	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FMT X 701

Chain	Residue
X	TYR491
X	PRO492
X	GLU493
X	ARG494
X	HOH840

---

site_id	AC2
Number of Residues	6
Details	binding site for residue FMT X 702

Chain	Residue
X	HOH832
X	HOH951
X	TYR334
X	SER363
X	ARG380
X	ASN382

---

site_id	AC3
Number of Residues	5
Details	binding site for residue FMT X 703

Chain	Residue
X	MET399
X	TYR473
X	TYR491
X	ILE500
X	HOH826

---

site_id	AC4
Number of Residues	4
Details	binding site for residue FMT X 704

Chain	Residue
X	ASN381
X	SER383
X	GLY386
X	THR388

---

site_id	AC5
Number of Residues	5
Details	binding site for residue FMT X 705

Chain	Residue
A	ARG336
A	GLN337
X	TYR334
X	PHE577
X	HOH874

---

site_id	AC6
Number of Residues	5
Details	binding site for residue NA X 706

Chain	Residue
X	VAL465
X	VAL512
X	HOH813
X	HOH944
X	HOH983

---

site_id	AC7
Number of Residues	6
Details	binding site for residue NA X 707

Chain	Residue
X	ASN382
X	SER383
X	GLY386
X	ASN387
X	HOH977
X	HOH980

---

site_id	AC8
Number of Residues	5
Details	binding site for residue FMT A 701

Chain	Residue
A	TYR491
A	PRO492
A	GLU493
A	ARG494
A	HOH840

---

site_id	AC9
Number of Residues	4
Details	binding site for residue FMT A 702

Chain	Residue
A	MET399
A	TYR473
A	HOH806
A	HOH813

---

site_id	AD1
Number of Residues	9
Details	binding site for residue FMT A 703

Chain	Residue
A	ALA366
A	GLY367
A	ILE559
A	GLY605
A	VAL606
A	HOH801
A	HOH812
A	HOH900
A	HOH970

---

site_id	AD2
Number of Residues	1
Details	binding site for residue FMT A 704

Chain	Residue
A	PHE546

---

site_id	AD3
Number of Residues	6
Details	binding site for residue NA A 705

Chain	Residue
A	ASN382
A	SER383
A	GLY386
A	ASN387
A	HOH927
A	HOH991

---

site_id	AD4
Number of Residues	6
Details	binding site for residue NA A 706

Chain	Residue
A	VAL465
A	VAL512
A	HOH801
A	HOH896
A	HOH973
A	HOH994

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	100
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	92
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	92
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	92
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---