6RMW
Structure of N-terminal truncated IMP bound Plasmodium falciparum IMP-nucleotidase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006190 | biological_process | inosine salvage |
| A | 0006204 | biological_process | IMP catabolic process |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| A | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| A | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006190 | biological_process | inosine salvage |
| B | 0006204 | biological_process | IMP catabolic process |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| B | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| B | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006190 | biological_process | inosine salvage |
| C | 0006204 | biological_process | IMP catabolic process |
| C | 0009117 | biological_process | nucleotide metabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| C | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| C | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006190 | biological_process | inosine salvage |
| D | 0006204 | biological_process | IMP catabolic process |
| D | 0009117 | biological_process | nucleotide metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| D | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| D | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006190 | biological_process | inosine salvage |
| E | 0006204 | biological_process | IMP catabolic process |
| E | 0009117 | biological_process | nucleotide metabolic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| E | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| E | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006190 | biological_process | inosine salvage |
| F | 0006204 | biological_process | IMP catabolic process |
| F | 0009117 | biological_process | nucleotide metabolic process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| F | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| F | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
| G | 0000287 | molecular_function | magnesium ion binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006190 | biological_process | inosine salvage |
| G | 0006204 | biological_process | IMP catabolic process |
| G | 0009117 | biological_process | nucleotide metabolic process |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| G | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| G | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
| H | 0000287 | molecular_function | magnesium ion binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006190 | biological_process | inosine salvage |
| H | 0006204 | biological_process | IMP catabolic process |
| H | 0009117 | biological_process | nucleotide metabolic process |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
| H | 0071590 | biological_process | nicotinamide riboside biosynthetic process |
| H | 0071592 | biological_process | nicotinic acid riboside biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue IMP A 501 |
| Chain | Residue |
| A | ASP170 |
| A | PHE358 |
| A | ASP363 |
| A | TRP365 |
| A | ASP367 |
| A | LYS371 |
| A | GLN395 |
| A | ASN401 |
| A | MG502 |
| A | ASN172 |
| A | ASP178 |
| A | THR204 |
| A | ALA205 |
| A | ALA206 |
| A | SER207 |
| A | LYS305 |
| A | SER308 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | ASP170 |
| A | ASN172 |
| A | ASP394 |
| A | GLN395 |
| A | IMP501 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue IMP B 501 |
| Chain | Residue |
| B | ASP170 |
| B | ASN172 |
| B | THR204 |
| B | ALA205 |
| B | SER207 |
| B | SER308 |
| B | GLY360 |
| B | ASP363 |
| B | TRP365 |
| B | LYS371 |
| B | ASN401 |
| B | MG502 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 502 |
| Chain | Residue |
| B | ASP170 |
| B | ASN172 |
| B | ASP394 |
| B | IMP501 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue IMP C 501 |
| Chain | Residue |
| C | ASP170 |
| C | ASN172 |
| C | THR204 |
| C | ALA205 |
| C | SER207 |
| C | LYS305 |
| C | SER308 |
| C | PHE358 |
| C | GLY360 |
| C | ASP363 |
| C | TRP365 |
| C | ASP367 |
| C | LYS371 |
| C | GLN395 |
| C | ASN401 |
| C | MG502 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 502 |
| Chain | Residue |
| C | ASP170 |
| C | ASN172 |
| C | ASP394 |
| C | GLN395 |
| C | IMP501 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 502 |
| Chain | Residue |
| D | ASP170 |
| D | ASN172 |
| D | ASP394 |
| D | IMP501 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| D | GLN216 |
| D | GLU255 |
| D | ALA256 |
| D | THR257 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue IMP E 501 |
| Chain | Residue |
| E | ASP170 |
| E | ASN172 |
| E | ASP178 |
| E | THR204 |
| E | ALA205 |
| E | SER207 |
| E | LYS305 |
| E | PHE358 |
| E | GLY360 |
| E | ASP363 |
| E | TRP365 |
| E | ASP367 |
| E | LYS371 |
| E | ASN401 |
| E | MG502 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 502 |
| Chain | Residue |
| E | ASP170 |
| E | ASN172 |
| E | ASP394 |
| E | IMP501 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 503 |
| Chain | Residue |
| E | GLN216 |
| E | GLU220 |
| E | GLU255 |
| E | ALA256 |
| E | THR257 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MG F 502 |
| Chain | Residue |
| F | ASP170 |
| F | ASN172 |
| F | ASP394 |
| F | GLN395 |
| F | IMP501 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MG G 502 |
| Chain | Residue |
| G | GLN395 |
| G | ASP402 |
| G | IMP501 |
| G | ASP170 |
| G | ASN172 |
| G | ASP394 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residue IMP H 501 |
| Chain | Residue |
| H | ASP170 |
| H | ASN172 |
| H | THR204 |
| H | ALA205 |
| H | ALA206 |
| H | SER207 |
| H | SER308 |
| H | ASP363 |
| H | TRP365 |
| H | LYS371 |
| H | ASN401 |
| H | MG502 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue MG H 502 |
| Chain | Residue |
| H | ASP170 |
| H | ASN172 |
| H | ASP394 |
| H | IMP501 |
| site_id | AD7 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide IMP D 501 and ASN D 401 |
| Chain | Residue |
| D | ASP170 |
| D | ASN172 |
| D | THR204 |
| D | ALA205 |
| D | SER207 |
| D | GLU245 |
| D | LYS305 |
| D | SER308 |
| D | PHE358 |
| D | ASP363 |
| D | TRP365 |
| D | ASP367 |
| D | LYS371 |
| D | GLN395 |
| D | GLY400 |
| D | ASP402 |
| D | PHE403 |
| D | MG502 |
| site_id | AD8 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide IMP F 501 and ASN F 401 |
| Chain | Residue |
| F | ASP170 |
| F | ASN172 |
| F | THR204 |
| F | ALA205 |
| F | ALA206 |
| F | SER207 |
| F | GLU245 |
| F | LYS305 |
| F | SER308 |
| F | PHE358 |
| F | GLY360 |
| F | ASP363 |
| F | TRP365 |
| F | ASP367 |
| F | LYS371 |
| F | ASP394 |
| F | GLN395 |
| F | GLY400 |
| F | ASP402 |
| F | PHE403 |
| F | MG502 |
| site_id | AD9 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide IMP F 501 and SER F 207 |
| Chain | Residue |
| F | ASP170 |
| F | ASN172 |
| F | THR204 |
| F | ALA205 |
| F | ALA206 |
| F | TYR208 |
| F | ASN209 |
| F | LYS305 |
| F | SER308 |
| F | GLY360 |
| F | ASP363 |
| F | TRP365 |
| F | ASP367 |
| F | LYS371 |
| F | ASP394 |
| F | ASN401 |
| F | MG502 |
| site_id | AE1 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide IMP G 501 and ASN G 401 |
| Chain | Residue |
| G | ASP170 |
| G | ASN172 |
| G | THR204 |
| G | ALA205 |
| G | ALA206 |
| G | SER207 |
| G | SER308 |
| G | CYS356 |
| G | PHE358 |
| G | ASP363 |
| G | TRP365 |
| G | ASP367 |
| G | LYS371 |
| G | GLN395 |
| G | GLY400 |
| G | ASP402 |
| G | PHE403 |
| G | PRO404 |
| G | MG502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:32591529 |
| Chain | Residue | Details |
| A | ASP170 | |
| B | ASP170 | |
| C | ASP170 | |
| D | ASP170 | |
| E | ASP170 | |
| F | ASP170 | |
| G | ASP170 | |
| H | ASP170 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:32591529 |
| Chain | Residue | Details |
| A | ASN172 | |
| B | ASN172 | |
| C | ASN172 | |
| D | ASN172 | |
| E | ASN172 | |
| F | ASN172 | |
| G | ASN172 | |
| H | ASN172 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32591529, ECO:0007744|PDB:6RMD |
| Chain | Residue | Details |
| A | LYS132 | |
| A | HIS150 | |
| B | LYS132 | |
| B | HIS150 | |
| C | LYS132 | |
| C | HIS150 | |
| D | LYS132 | |
| D | HIS150 | |
| E | LYS132 | |
| E | HIS150 | |
| F | LYS132 | |
| F | HIS150 | |
| G | LYS132 | |
| G | HIS150 | |
| H | LYS132 | |
| H | HIS150 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32591529, ECO:0007744|PDB:6RME, ECO:0007744|PDB:6RMW |
| Chain | Residue | Details |
| A | ASP170 | |
| A | ASN172 | |
| A | ASP178 | |
| A | THR204 | |
| A | SER207 | |
| A | SER308 | |
| A | ASP363 | |
| A | LYS371 | |
| A | ASP394 | |
| B | ASP170 | |
| B | ASN172 | |
| B | ASP178 | |
| B | THR204 | |
| B | SER207 | |
| B | SER308 | |
| B | ASP363 | |
| B | LYS371 | |
| B | ASP394 | |
| C | ASP170 | |
| C | ASN172 | |
| C | ASP178 | |
| C | THR204 | |
| C | SER207 | |
| C | SER308 | |
| C | ASP363 | |
| C | LYS371 | |
| C | ASP394 | |
| D | ASP170 | |
| D | ASN172 | |
| D | ASP178 | |
| D | THR204 | |
| D | SER207 | |
| D | SER308 | |
| D | ASP363 | |
| D | LYS371 | |
| D | ASP394 | |
| E | ASP170 | |
| E | ASN172 | |
| E | ASP178 | |
| E | THR204 | |
| E | SER207 | |
| E | SER308 | |
| E | ASP363 | |
| E | LYS371 | |
| E | ASP394 | |
| F | ASP170 | |
| F | ASN172 | |
| F | ASP178 | |
| F | THR204 | |
| F | SER207 | |
| F | SER308 | |
| F | ASP363 | |
| F | LYS371 | |
| F | ASP394 | |
| G | ASP170 | |
| G | ASN172 | |
| G | ASP178 | |
| G | THR204 | |
| G | SER207 | |
| G | SER308 | |
| G | ASP363 | |
| G | LYS371 | |
| G | ASP394 | |
| H | ASP170 | |
| H | ASN172 | |
| H | ASP178 | |
| H | THR204 | |
| H | SER207 | |
| H | SER308 | |
| H | ASP363 | |
| H | LYS371 | |
| H | ASP394 |
