6RMW

Structure of N-terminal truncated IMP bound Plasmodium falciparum IMP-nucleotidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006190	biological_process	inosine salvage
A	0006204	biological_process	IMP catabolic process
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0071590	biological_process	nicotinamide riboside biosynthetic process
A	0071592	biological_process	nicotinic acid riboside biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006190	biological_process	inosine salvage
B	0006204	biological_process	IMP catabolic process
B	0008253	molecular_function	5'-nucleotidase activity
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0071590	biological_process	nicotinamide riboside biosynthetic process
B	0071592	biological_process	nicotinic acid riboside biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006190	biological_process	inosine salvage
C	0006204	biological_process	IMP catabolic process
C	0008253	molecular_function	5'-nucleotidase activity
C	0009117	biological_process	nucleotide metabolic process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0071590	biological_process	nicotinamide riboside biosynthetic process
C	0071592	biological_process	nicotinic acid riboside biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006190	biological_process	inosine salvage
D	0006204	biological_process	IMP catabolic process
D	0008253	molecular_function	5'-nucleotidase activity
D	0009117	biological_process	nucleotide metabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0071590	biological_process	nicotinamide riboside biosynthetic process
D	0071592	biological_process	nicotinic acid riboside biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006190	biological_process	inosine salvage
E	0006204	biological_process	IMP catabolic process
E	0008253	molecular_function	5'-nucleotidase activity
E	0009117	biological_process	nucleotide metabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
E	0071590	biological_process	nicotinamide riboside biosynthetic process
E	0071592	biological_process	nicotinic acid riboside biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006190	biological_process	inosine salvage
F	0006204	biological_process	IMP catabolic process
F	0008253	molecular_function	5'-nucleotidase activity
F	0009117	biological_process	nucleotide metabolic process
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
F	0071590	biological_process	nicotinamide riboside biosynthetic process
F	0071592	biological_process	nicotinic acid riboside biosynthetic process
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006190	biological_process	inosine salvage
G	0006204	biological_process	IMP catabolic process
G	0008253	molecular_function	5'-nucleotidase activity
G	0009117	biological_process	nucleotide metabolic process
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
G	0071590	biological_process	nicotinamide riboside biosynthetic process
G	0071592	biological_process	nicotinic acid riboside biosynthetic process
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006190	biological_process	inosine salvage
H	0006204	biological_process	IMP catabolic process
H	0008253	molecular_function	5'-nucleotidase activity
H	0009117	biological_process	nucleotide metabolic process
H	0016787	molecular_function	hydrolase activity
H	0046872	molecular_function	metal ion binding
H	0071590	biological_process	nicotinamide riboside biosynthetic process
H	0071592	biological_process	nicotinic acid riboside biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue IMP A 501

Chain	Residue
A	ASP170
A	PHE358
A	ASP363
A	TRP365
A	ASP367
A	LYS371
A	GLN395
A	ASN401
A	MG502
A	ASN172
A	ASP178
A	THR204
A	ALA205
A	ALA206
A	SER207
A	LYS305
A	SER308

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 502

Chain	Residue
A	ASP170
A	ASN172
A	ASP394
A	GLN395
A	IMP501

---

site_id	AC3
Number of Residues	12
Details	binding site for residue IMP B 501

Chain	Residue
B	ASP170
B	ASN172
B	THR204
B	ALA205
B	SER207
B	SER308
B	GLY360
B	ASP363
B	TRP365
B	LYS371
B	ASN401
B	MG502

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG B 502

Chain	Residue
B	ASP170
B	ASN172
B	ASP394
B	IMP501

---

site_id	AC5
Number of Residues	16
Details	binding site for residue IMP C 501

Chain	Residue
C	ASP170
C	ASN172
C	THR204
C	ALA205
C	SER207
C	LYS305
C	SER308
C	PHE358
C	GLY360
C	ASP363
C	TRP365
C	ASP367
C	LYS371
C	GLN395
C	ASN401
C	MG502

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MG C 502

Chain	Residue
C	ASP170
C	ASN172
C	ASP394
C	GLN395
C	IMP501

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MG D 502

Chain	Residue
D	ASP170
D	ASN172
D	ASP394
D	IMP501

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL D 503

Chain	Residue
D	GLN216
D	GLU255
D	ALA256
D	THR257

---

site_id	AC9
Number of Residues	15
Details	binding site for residue IMP E 501

Chain	Residue
E	ASP170
E	ASN172
E	ASP178
E	THR204
E	ALA205
E	SER207
E	LYS305
E	PHE358
E	GLY360
E	ASP363
E	TRP365
E	ASP367
E	LYS371
E	ASN401
E	MG502

---

site_id	AD1
Number of Residues	4
Details	binding site for residue MG E 502

Chain	Residue
E	ASP170
E	ASN172
E	ASP394
E	IMP501

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL E 503

Chain	Residue
E	GLN216
E	GLU220
E	GLU255
E	ALA256
E	THR257

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MG F 502

Chain	Residue
F	ASP170
F	ASN172
F	ASP394
F	GLN395
F	IMP501

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MG G 502

Chain	Residue
G	GLN395
G	ASP402
G	IMP501
G	ASP170
G	ASN172
G	ASP394

---

site_id	AD5
Number of Residues	12
Details	binding site for residue IMP H 501

Chain	Residue
H	ASP170
H	ASN172
H	THR204
H	ALA205
H	ALA206
H	SER207
H	SER308
H	ASP363
H	TRP365
H	LYS371
H	ASN401
H	MG502

---

site_id	AD6
Number of Residues	4
Details	binding site for residue MG H 502

Chain	Residue
H	ASP170
H	ASN172
H	ASP394
H	IMP501

---

site_id	AD7
Number of Residues	18
Details	binding site for Di-peptide IMP D 501 and ASN D 401

Chain	Residue
D	ASP170
D	ASN172
D	THR204
D	ALA205
D	SER207
D	GLU245
D	LYS305
D	SER308
D	PHE358
D	ASP363
D	TRP365
D	ASP367
D	LYS371
D	GLN395
D	GLY400
D	ASP402
D	PHE403
D	MG502

---

site_id	AD8
Number of Residues	21
Details	binding site for Di-peptide IMP F 501 and ASN F 401

Chain	Residue
F	ASP170
F	ASN172
F	THR204
F	ALA205
F	ALA206
F	SER207
F	GLU245
F	LYS305
F	SER308
F	PHE358
F	GLY360
F	ASP363
F	TRP365
F	ASP367
F	LYS371
F	ASP394
F	GLN395
F	GLY400
F	ASP402
F	PHE403
F	MG502

---

site_id	AD9
Number of Residues	17
Details	binding site for Di-peptide IMP F 501 and SER F 207

Chain	Residue
F	ASP170
F	ASN172
F	THR204
F	ALA205
F	ALA206
F	TYR208
F	ASN209
F	LYS305
F	SER308
F	GLY360
F	ASP363
F	TRP365
F	ASP367
F	LYS371
F	ASP394
F	ASN401
F	MG502

---

site_id	AE1
Number of Residues	19
Details	binding site for Di-peptide IMP G 501 and ASN G 401

Chain	Residue
G	ASP170
G	ASN172
G	THR204
G	ALA205
G	ALA206
G	SER207
G	SER308
G	CYS356
G	PHE358
G	ASP363
G	TRP365
G	ASP367
G	LYS371
G	GLN395
G	GLY400
G	ASP402
G	PHE403
G	PRO404
G	MG502

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"32591529","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"32591529","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32591529","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RMD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32591529","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RME","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RMW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---