6RMO

Structure of Plasmodium falciparum IMP-nucleotidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006190	biological_process	inosine salvage
A	0006204	biological_process	IMP catabolic process
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0050483	molecular_function	IMP 5'-nucleotidase activity
A	0071590	biological_process	nicotinamide riboside biosynthetic process
A	0071592	biological_process	nicotinic acid riboside biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006190	biological_process	inosine salvage
B	0006204	biological_process	IMP catabolic process
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0050483	molecular_function	IMP 5'-nucleotidase activity
B	0071590	biological_process	nicotinamide riboside biosynthetic process
B	0071592	biological_process	nicotinic acid riboside biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006190	biological_process	inosine salvage
C	0006204	biological_process	IMP catabolic process
C	0009117	biological_process	nucleotide metabolic process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0050483	molecular_function	IMP 5'-nucleotidase activity
C	0071590	biological_process	nicotinamide riboside biosynthetic process
C	0071592	biological_process	nicotinic acid riboside biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006190	biological_process	inosine salvage
D	0006204	biological_process	IMP catabolic process
D	0009117	biological_process	nucleotide metabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0050483	molecular_function	IMP 5'-nucleotidase activity
D	0071590	biological_process	nicotinamide riboside biosynthetic process
D	0071592	biological_process	nicotinic acid riboside biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006190	biological_process	inosine salvage
E	0006204	biological_process	IMP catabolic process
E	0009117	biological_process	nucleotide metabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
E	0050483	molecular_function	IMP 5'-nucleotidase activity
E	0071590	biological_process	nicotinamide riboside biosynthetic process
E	0071592	biological_process	nicotinic acid riboside biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006190	biological_process	inosine salvage
F	0006204	biological_process	IMP catabolic process
F	0009117	biological_process	nucleotide metabolic process
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
F	0050483	molecular_function	IMP 5'-nucleotidase activity
F	0071590	biological_process	nicotinamide riboside biosynthetic process
F	0071592	biological_process	nicotinic acid riboside biosynthetic process
G	0000287	molecular_function	magnesium ion binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006190	biological_process	inosine salvage
G	0006204	biological_process	IMP catabolic process
G	0009117	biological_process	nucleotide metabolic process
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
G	0050483	molecular_function	IMP 5'-nucleotidase activity
G	0071590	biological_process	nicotinamide riboside biosynthetic process
G	0071592	biological_process	nicotinic acid riboside biosynthetic process
H	0000287	molecular_function	magnesium ion binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006190	biological_process	inosine salvage
H	0006204	biological_process	IMP catabolic process
H	0009117	biological_process	nucleotide metabolic process
H	0016787	molecular_function	hydrolase activity
H	0046872	molecular_function	metal ion binding
H	0050483	molecular_function	IMP 5'-nucleotidase activity
H	0071590	biological_process	nicotinamide riboside biosynthetic process
H	0071592	biological_process	nicotinic acid riboside biosynthetic process
I	0000287	molecular_function	magnesium ion binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006190	biological_process	inosine salvage
I	0006204	biological_process	IMP catabolic process
I	0009117	biological_process	nucleotide metabolic process
I	0016787	molecular_function	hydrolase activity
I	0046872	molecular_function	metal ion binding
I	0050483	molecular_function	IMP 5'-nucleotidase activity
I	0071590	biological_process	nicotinamide riboside biosynthetic process
I	0071592	biological_process	nicotinic acid riboside biosynthetic process
J	0000287	molecular_function	magnesium ion binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006190	biological_process	inosine salvage
J	0006204	biological_process	IMP catabolic process
J	0009117	biological_process	nucleotide metabolic process
J	0016787	molecular_function	hydrolase activity
J	0046872	molecular_function	metal ion binding
J	0050483	molecular_function	IMP 5'-nucleotidase activity
J	0071590	biological_process	nicotinamide riboside biosynthetic process
J	0071592	biological_process	nicotinic acid riboside biosynthetic process
K	0000287	molecular_function	magnesium ion binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0006190	biological_process	inosine salvage
K	0006204	biological_process	IMP catabolic process
K	0009117	biological_process	nucleotide metabolic process
K	0016787	molecular_function	hydrolase activity
K	0046872	molecular_function	metal ion binding
K	0050483	molecular_function	IMP 5'-nucleotidase activity
K	0071590	biological_process	nicotinamide riboside biosynthetic process
K	0071592	biological_process	nicotinic acid riboside biosynthetic process
L	0000287	molecular_function	magnesium ion binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0006190	biological_process	inosine salvage
L	0006204	biological_process	IMP catabolic process
L	0009117	biological_process	nucleotide metabolic process
L	0016787	molecular_function	hydrolase activity
L	0046872	molecular_function	metal ion binding
L	0050483	molecular_function	IMP 5'-nucleotidase activity
L	0071590	biological_process	nicotinamide riboside biosynthetic process
L	0071592	biological_process	nicotinic acid riboside biosynthetic process
M	0000287	molecular_function	magnesium ion binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0006190	biological_process	inosine salvage
M	0006204	biological_process	IMP catabolic process
M	0009117	biological_process	nucleotide metabolic process
M	0016787	molecular_function	hydrolase activity
M	0046872	molecular_function	metal ion binding
M	0050483	molecular_function	IMP 5'-nucleotidase activity
M	0071590	biological_process	nicotinamide riboside biosynthetic process
M	0071592	biological_process	nicotinic acid riboside biosynthetic process
N	0000287	molecular_function	magnesium ion binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0006190	biological_process	inosine salvage
N	0006204	biological_process	IMP catabolic process
N	0009117	biological_process	nucleotide metabolic process
N	0016787	molecular_function	hydrolase activity
N	0046872	molecular_function	metal ion binding
N	0050483	molecular_function	IMP 5'-nucleotidase activity
N	0071590	biological_process	nicotinamide riboside biosynthetic process
N	0071592	biological_process	nicotinic acid riboside biosynthetic process
O	0000287	molecular_function	magnesium ion binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0006190	biological_process	inosine salvage
O	0006204	biological_process	IMP catabolic process
O	0009117	biological_process	nucleotide metabolic process
O	0016787	molecular_function	hydrolase activity
O	0046872	molecular_function	metal ion binding
O	0050483	molecular_function	IMP 5'-nucleotidase activity
O	0071590	biological_process	nicotinamide riboside biosynthetic process
O	0071592	biological_process	nicotinic acid riboside biosynthetic process
P	0000287	molecular_function	magnesium ion binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0006190	biological_process	inosine salvage
P	0006204	biological_process	IMP catabolic process
P	0009117	biological_process	nucleotide metabolic process
P	0016787	molecular_function	hydrolase activity
P	0046872	molecular_function	metal ion binding
P	0050483	molecular_function	IMP 5'-nucleotidase activity
P	0071590	biological_process	nicotinamide riboside biosynthetic process
P	0071592	biological_process	nicotinic acid riboside biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:32591529

Chain	Residue	Details
A	ASP170
J	ASP170
K	ASP170
L	ASP170
M	ASP170
N	ASP170
O	ASP170
P	ASP170
B	ASP170
C	ASP170
D	ASP170
E	ASP170
F	ASP170
G	ASP170
H	ASP170
I	ASP170

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site_id	SWS_FT_FI2
Number of Residues	16
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:32591529

Chain	Residue	Details
A	ASP172
J	ASP172
K	ASP172
L	ASP172
M	ASP172
N	ASP172
O	ASP172
P	ASP172
B	ASP172
C	ASP172
D	ASP172
E	ASP172
F	ASP172
G	ASP172
H	ASP172
I	ASP172

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:32591529, ECO:0007744|PDB:6RMD

Chain	Residue	Details
A	LYS132
E	HIS150
F	LYS132
F	HIS150
G	LYS132
G	HIS150
H	LYS132
H	HIS150
I	LYS132
I	HIS150
J	LYS132
A	HIS150
J	HIS150
K	LYS132
K	HIS150
L	LYS132
L	HIS150
M	LYS132
M	HIS150
N	LYS132
N	HIS150
O	LYS132
B	LYS132
O	HIS150
P	LYS132
P	HIS150
B	HIS150
C	LYS132
C	HIS150
D	LYS132
D	HIS150
E	LYS132

---

site_id	SWS_FT_FI4
Number of Residues	144
Details	BINDING: BINDING => ECO:0000269|PubMed:32591529, ECO:0007744|PDB:6RME, ECO:0007744|PDB:6RMW

Chain	Residue	Details
A	ASP170
B	ASP170
L	ASP170
L	ASP172
L	ASP178
L	THR204
L	SER207
L	SER308
L	ASP363
L	LYS371
L	ASP394
M	ASP170
B	ASP172
M	ASP172
M	ASP178
M	THR204
M	SER207
M	SER308
M	ASP363
M	LYS371
M	ASP394
N	ASP170
N	ASP172
B	ASP178
N	ASP178
N	THR204
N	SER207
N	SER308
N	ASP363
N	LYS371
N	ASP394
O	ASP170
O	ASP172
O	ASP178
B	THR204
O	THR204
O	SER207
O	SER308
O	ASP363
O	LYS371
O	ASP394
P	ASP170
P	ASP172
P	ASP178
P	THR204
B	SER207
P	SER207
P	SER308
P	ASP363
P	LYS371
P	ASP394
B	SER308
B	ASP363
B	LYS371
B	ASP394
C	ASP170
A	ASP172
C	ASP172
C	ASP178
C	THR204
C	SER207
C	SER308
C	ASP363
C	LYS371
C	ASP394
D	ASP170
D	ASP172
A	ASP178
D	ASP178
D	THR204
D	SER207
D	SER308
D	ASP363
D	LYS371
D	ASP394
E	ASP170
E	ASP172
E	ASP178
A	THR204
E	THR204
E	SER207
E	SER308
E	ASP363
E	LYS371
E	ASP394
F	ASP170
F	ASP172
F	ASP178
F	THR204
A	SER207
F	SER207
F	SER308
F	ASP363
F	LYS371
F	ASP394
G	ASP170
G	ASP172
G	ASP178
G	THR204
G	SER207
A	SER308
G	SER308
G	ASP363
G	LYS371
G	ASP394
H	ASP170
H	ASP172
H	ASP178
H	THR204
H	SER207
H	SER308
A	ASP363
H	ASP363
H	LYS371
H	ASP394
I	ASP170
I	ASP172
I	ASP178
I	THR204
I	SER207
I	SER308
I	ASP363
A	LYS371
I	LYS371
I	ASP394
J	ASP170
J	ASP172
J	ASP178
J	THR204
J	SER207
J	SER308
J	ASP363
J	LYS371
A	ASP394
J	ASP394
K	ASP170
K	ASP172
K	ASP178
K	THR204
K	SER207
K	SER308
K	ASP363
K	LYS371
K	ASP394

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