6RLD
STRUCTURE OF THE MECHANOSENSITIVE CHANNEL MSCS EMBEDDED IN THE MEMBRANE BILAYER
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005886 | cellular_component | plasma membrane |
A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
A | 0009992 | biological_process | intracellular water homeostasis |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0042802 | molecular_function | identical protein binding |
A | 0051260 | biological_process | protein homooligomerization |
A | 0055085 | biological_process | transmembrane transport |
B | 0005886 | cellular_component | plasma membrane |
B | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
B | 0009992 | biological_process | intracellular water homeostasis |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0042802 | molecular_function | identical protein binding |
B | 0051260 | biological_process | protein homooligomerization |
B | 0055085 | biological_process | transmembrane transport |
C | 0005886 | cellular_component | plasma membrane |
C | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
C | 0009992 | biological_process | intracellular water homeostasis |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0042802 | molecular_function | identical protein binding |
C | 0051260 | biological_process | protein homooligomerization |
C | 0055085 | biological_process | transmembrane transport |
D | 0005886 | cellular_component | plasma membrane |
D | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
D | 0009992 | biological_process | intracellular water homeostasis |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0042802 | molecular_function | identical protein binding |
D | 0051260 | biological_process | protein homooligomerization |
D | 0055085 | biological_process | transmembrane transport |
E | 0005886 | cellular_component | plasma membrane |
E | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
E | 0009992 | biological_process | intracellular water homeostasis |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0042802 | molecular_function | identical protein binding |
E | 0051260 | biological_process | protein homooligomerization |
E | 0055085 | biological_process | transmembrane transport |
F | 0005886 | cellular_component | plasma membrane |
F | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
F | 0009992 | biological_process | intracellular water homeostasis |
F | 0016020 | cellular_component | membrane |
F | 0034220 | biological_process | monoatomic ion transmembrane transport |
F | 0042802 | molecular_function | identical protein binding |
F | 0051260 | biological_process | protein homooligomerization |
F | 0055085 | biological_process | transmembrane transport |
G | 0005886 | cellular_component | plasma membrane |
G | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
G | 0009992 | biological_process | intracellular water homeostasis |
G | 0016020 | cellular_component | membrane |
G | 0034220 | biological_process | monoatomic ion transmembrane transport |
G | 0042802 | molecular_function | identical protein binding |
G | 0051260 | biological_process | protein homooligomerization |
G | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue PCW B 603 |
Chain | Residue |
A | LYS60 |
A | GLY104 |
B | PCW602 |
B | THR64 |
B | PHE68 |
B | ALA106 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue PCW B 602 |
Chain | Residue |
A | ARG59 |
B | PCW603 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue PCW A 603 |
Chain | Residue |
A | PHE68 |
A | VAL107 |
G | LYS60 |
G | GLY104 |
A | PCW602 |
A | THR64 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue PCW C 602 |
Chain | Residue |
B | ARG59 |
C | PCW603 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue PCW B 601 |
Chain | Residue |
A | ALA33 |
A | VAL40 |
A | ARG88 |
B | TYR27 |
B | ASN30 |
B | ILE31 |
B | ILE38 |
B | VAL89 |
B | GLN92 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue PCW C 603 |
Chain | Residue |
B | LYS60 |
B | GLY104 |
C | PCW602 |
C | THR64 |
C | PHE68 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue PCW D 603 |
Chain | Residue |
C | LYS60 |
C | GLY104 |
D | PCW602 |
D | THR64 |
D | PHE68 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue PCW D 602 |
Chain | Residue |
C | ARG59 |
D | PCW603 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue PCW C 601 |
Chain | Residue |
B | ALA33 |
B | VAL40 |
B | ARG88 |
C | TYR27 |
C | ASN30 |
C | ILE31 |
C | ILE38 |
C | VAL89 |
C | GLN92 |
site_id | AD1 |
Number of Residues | 11 |
Details | binding site for residue PCW D 601 |
Chain | Residue |
C | ALA33 |
C | ILE37 |
C | VAL40 |
C | PHE80 |
C | ARG88 |
D | TYR27 |
D | ASN30 |
D | ILE31 |
D | ILE38 |
D | VAL89 |
D | GLN92 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue PCW E 602 |
Chain | Residue |
D | ARG59 |
E | PCW603 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue PCW E 603 |
Chain | Residue |
D | LYS60 |
D | GLY104 |
E | PCW602 |
E | THR64 |
E | PHE68 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue PCW F 603 |
Chain | Residue |
E | LYS60 |
E | GLY104 |
F | PCW602 |
F | THR64 |
F | PHE68 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue PCW F 602 |
Chain | Residue |
E | ARG59 |
F | PCW603 |
site_id | AD6 |
Number of Residues | 9 |
Details | binding site for residue PCW E 601 |
Chain | Residue |
D | ALA33 |
D | VAL40 |
D | ARG88 |
E | TYR27 |
E | ASN30 |
E | ILE31 |
E | ILE38 |
E | VAL89 |
E | GLN92 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue PCW G 603 |
Chain | Residue |
F | LYS60 |
F | GLY104 |
G | PCW602 |
G | THR64 |
G | PHE68 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue PCW G 602 |
Chain | Residue |
F | ARG59 |
G | PCW603 |
site_id | AD9 |
Number of Residues | 8 |
Details | binding site for residue PCW F 601 |
Chain | Residue |
E | ALA33 |
E | ARG88 |
F | TYR27 |
F | ASN30 |
F | ILE31 |
F | ILE38 |
F | VAL89 |
F | GLN92 |
site_id | AE1 |
Number of Residues | 11 |
Details | binding site for residue PCW A 801 |
Chain | Residue |
A | VAL89 |
A | GLN92 |
G | ALA33 |
G | ILE37 |
G | VAL40 |
G | PHE80 |
G | ARG88 |
A | TYR27 |
A | ASN30 |
A | ILE31 |
A | ILE38 |
site_id | AE2 |
Number of Residues | 2 |
Details | binding site for residue PCW A 602 |
Chain | Residue |
A | PCW603 |
G | ARG59 |
site_id | AE3 |
Number of Residues | 8 |
Details | binding site for residue PCW G 601 |
Chain | Residue |
F | ALA33 |
F | ARG88 |
G | TYR27 |
G | ASN30 |
G | ILE31 |
G | ILE38 |
G | VAL89 |
G | GLN92 |
Functional Information from PROSITE/UniProt
site_id | PS01246 |
Number of Residues | 35 |
Details | UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN |
Chain | Residue | Details |
A | GLY143-ASN177 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 210 |
Details | TOPO_DOM: Periplasmic => ECO:0000305|PubMed:15919996 |
Chain | Residue | Details |
A | MET1-ASN30 | |
E | VAL89-GLY90 | |
F | MET1-ASN30 | |
F | VAL89-GLY90 | |
G | MET1-ASN30 | |
G | VAL89-GLY90 | |
A | VAL89-GLY90 | |
B | MET1-ASN30 | |
B | VAL89-GLY90 | |
C | MET1-ASN30 | |
C | VAL89-GLY90 | |
D | MET1-ASN30 | |
D | VAL89-GLY90 | |
E | MET1-ASN30 |
site_id | SWS_FT_FI2 |
Number of Residues | 427 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077 |
Chain | Residue | Details |
A | ILE31-VAL52 | |
D | ILE31-VAL52 | |
D | PHE68-ARG88 | |
D | VAL91-LEU111 | |
E | ILE31-VAL52 | |
E | PHE68-ARG88 | |
E | VAL91-LEU111 | |
F | ILE31-VAL52 | |
F | PHE68-ARG88 | |
F | VAL91-LEU111 | |
G | ILE31-VAL52 | |
A | PHE68-ARG88 | |
G | PHE68-ARG88 | |
G | VAL91-LEU111 | |
A | VAL91-LEU111 | |
B | ILE31-VAL52 | |
B | PHE68-ARG88 | |
B | VAL91-LEU111 | |
C | ILE31-VAL52 | |
C | PHE68-ARG88 | |
C | VAL91-LEU111 |
site_id | SWS_FT_FI3 |
Number of Residues | 1316 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:15919996 |
Chain | Residue | Details |
A | ASN53-ASP67 | |
E | GLN112-ALA286 | |
F | ASN53-ASP67 | |
F | GLN112-ALA286 | |
G | ASN53-ASP67 | |
G | GLN112-ALA286 | |
A | GLN112-ALA286 | |
B | ASN53-ASP67 | |
B | GLN112-ALA286 | |
C | ASN53-ASP67 | |
C | GLN112-ALA286 | |
D | ASN53-ASP67 | |
D | GLN112-ALA286 | |
E | ASN53-ASP67 |