Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6RLD

STRUCTURE OF THE MECHANOSENSITIVE CHANNEL MSCS EMBEDDED IN THE MEMBRANE BILAYER

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0009992	biological_process	intracellular water homeostasis
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0009992	biological_process	intracellular water homeostasis
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0009992	biological_process	intracellular water homeostasis
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
D	0009992	biological_process	intracellular water homeostasis
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
E	0009992	biological_process	intracellular water homeostasis
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
F	0009992	biological_process	intracellular water homeostasis
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
G	0009992	biological_process	intracellular water homeostasis
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PCW B 603

Chain	Residue
A	LYS60
A	GLY104
B	PCW602
B	THR64
B	PHE68
B	ALA106

site_id	AC2
Number of Residues	2
Details	binding site for residue PCW B 602

Chain	Residue
A	ARG59
B	PCW603

site_id	AC3
Number of Residues	6
Details	binding site for residue PCW A 603

Chain	Residue
A	PHE68
A	VAL107
G	LYS60
G	GLY104
A	PCW602
A	THR64

site_id	AC4
Number of Residues	2
Details	binding site for residue PCW C 602

Chain	Residue
B	ARG59
C	PCW603

site_id	AC5
Number of Residues	9
Details	binding site for residue PCW B 601

Chain	Residue
A	ALA33
A	VAL40
A	ARG88
B	TYR27
B	ASN30
B	ILE31
B	ILE38
B	VAL89
B	GLN92

site_id	AC6
Number of Residues	5
Details	binding site for residue PCW C 603

Chain	Residue
B	LYS60
B	GLY104
C	PCW602
C	THR64
C	PHE68

site_id	AC7
Number of Residues	5
Details	binding site for residue PCW D 603

Chain	Residue
C	LYS60
C	GLY104
D	PCW602
D	THR64
D	PHE68

site_id	AC8
Number of Residues	2
Details	binding site for residue PCW D 602

Chain	Residue
C	ARG59
D	PCW603

site_id	AC9
Number of Residues	9
Details	binding site for residue PCW C 601

Chain	Residue
B	ALA33
B	VAL40
B	ARG88
C	TYR27
C	ASN30
C	ILE31
C	ILE38
C	VAL89
C	GLN92

site_id	AD1
Number of Residues	11
Details	binding site for residue PCW D 601

Chain	Residue
C	ALA33
C	ILE37
C	VAL40
C	PHE80
C	ARG88
D	TYR27
D	ASN30
D	ILE31
D	ILE38
D	VAL89
D	GLN92

site_id	AD2
Number of Residues	2
Details	binding site for residue PCW E 602

Chain	Residue
D	ARG59
E	PCW603

site_id	AD3
Number of Residues	5
Details	binding site for residue PCW E 603

Chain	Residue
D	LYS60
D	GLY104
E	PCW602
E	THR64
E	PHE68

site_id	AD4
Number of Residues	5
Details	binding site for residue PCW F 603

Chain	Residue
E	LYS60
E	GLY104
F	PCW602
F	THR64
F	PHE68

site_id	AD5
Number of Residues	2
Details	binding site for residue PCW F 602

Chain	Residue
E	ARG59
F	PCW603

site_id	AD6
Number of Residues	9
Details	binding site for residue PCW E 601

Chain	Residue
D	ALA33
D	VAL40
D	ARG88
E	TYR27
E	ASN30
E	ILE31
E	ILE38
E	VAL89
E	GLN92

site_id	AD7
Number of Residues	5
Details	binding site for residue PCW G 603

Chain	Residue
F	LYS60
F	GLY104
G	PCW602
G	THR64
G	PHE68

site_id	AD8
Number of Residues	2
Details	binding site for residue PCW G 602

Chain	Residue
F	ARG59
G	PCW603

site_id	AD9
Number of Residues	8
Details	binding site for residue PCW F 601

Chain	Residue
E	ALA33
E	ARG88
F	TYR27
F	ASN30
F	ILE31
F	ILE38
F	VAL89
F	GLN92

site_id	AE1
Number of Residues	11
Details	binding site for residue PCW A 801

Chain	Residue
A	VAL89
A	GLN92
G	ALA33
G	ILE37
G	VAL40
G	PHE80
G	ARG88
A	TYR27
A	ASN30
A	ILE31
A	ILE38

site_id	AE2
Number of Residues	2
Details	binding site for residue PCW A 602

Chain	Residue
A	PCW603
G	ARG59

site_id	AE3
Number of Residues	8
Details	binding site for residue PCW G 601

Chain	Residue
F	ALA33
F	ARG88
G	TYR27
G	ASN30
G	ILE31
G	ILE38
G	VAL89
G	GLN92

Functional Information from PROSITE/UniProt

site_id	PS01246
Number of Residues	35
Details	UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN

Chain	Residue	Details
A	GLY143-ASN177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	210
Details	TOPO_DOM: Periplasmic => ECO:0000305\|PubMed:15919996

Chain	Residue	Details
A	MET1-ASN30
E	VAL89-GLY90
F	MET1-ASN30
F	VAL89-GLY90
G	MET1-ASN30
G	VAL89-GLY90
A	VAL89-GLY90
B	MET1-ASN30
B	VAL89-GLY90
C	MET1-ASN30
C	VAL89-GLY90
D	MET1-ASN30
D	VAL89-GLY90
E	MET1-ASN30

site_id	SWS_FT_FI2
Number of Residues	427
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:12446901, ECO:0000269\|PubMed:26551077

Chain	Residue	Details
A	ILE31-VAL52
D	ILE31-VAL52
D	PHE68-ARG88
D	VAL91-LEU111
E	ILE31-VAL52
E	PHE68-ARG88
E	VAL91-LEU111
F	ILE31-VAL52
F	PHE68-ARG88
F	VAL91-LEU111
G	ILE31-VAL52
A	PHE68-ARG88
G	PHE68-ARG88
G	VAL91-LEU111
A	VAL91-LEU111
B	ILE31-VAL52
B	PHE68-ARG88
B	VAL91-LEU111
C	ILE31-VAL52
C	PHE68-ARG88
C	VAL91-LEU111

site_id	SWS_FT_FI3
Number of Residues	1316
Details	TOPO_DOM: Cytoplasmic => ECO:0000305\|PubMed:15919996

Chain	Residue	Details
A	ASN53-ASP67
E	GLN112-ALA286
F	ASN53-ASP67
F	GLN112-ALA286
G	ASN53-ASP67
G	GLN112-ALA286
A	GLN112-ALA286
B	ASN53-ASP67
B	GLN112-ALA286
C	ASN53-ASP67
C	GLN112-ALA286
D	ASN53-ASP67
D	GLN112-ALA286
E	ASN53-ASP67

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)