Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6RKF

Structure of human DASPO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003884	molecular_function	D-amino-acid oxidase activity
A	0005515	molecular_function	protein binding
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006531	biological_process	aspartate metabolic process
A	0008445	molecular_function	D-aspartate oxidase activity
A	0010646	biological_process	regulation of cell communication
A	0019478	biological_process	D-amino acid catabolic process
A	0047821	molecular_function	D-glutamate oxidase activity
A	0050877	biological_process	nervous system process
A	0071949	molecular_function	FAD binding
B	0003884	molecular_function	D-amino-acid oxidase activity
B	0005515	molecular_function	protein binding
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006531	biological_process	aspartate metabolic process
B	0008445	molecular_function	D-aspartate oxidase activity
B	0010646	biological_process	regulation of cell communication
B	0019478	biological_process	D-amino acid catabolic process
B	0047821	molecular_function	D-glutamate oxidase activity
B	0050877	biological_process	nervous system process
B	0071949	molecular_function	FAD binding
C	0003884	molecular_function	D-amino-acid oxidase activity
C	0005515	molecular_function	protein binding
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006531	biological_process	aspartate metabolic process
C	0008445	molecular_function	D-aspartate oxidase activity
C	0010646	biological_process	regulation of cell communication
C	0019478	biological_process	D-amino acid catabolic process
C	0047821	molecular_function	D-glutamate oxidase activity
C	0050877	biological_process	nervous system process
C	0071949	molecular_function	FAD binding
D	0003884	molecular_function	D-amino-acid oxidase activity
D	0005515	molecular_function	protein binding
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006531	biological_process	aspartate metabolic process
D	0008445	molecular_function	D-aspartate oxidase activity
D	0010646	biological_process	regulation of cell communication
D	0019478	biological_process	D-amino acid catabolic process
D	0047821	molecular_function	D-glutamate oxidase activity
D	0050877	biological_process	nervous system process
D	0071949	molecular_function	FAD binding
E	0003884	molecular_function	D-amino-acid oxidase activity
E	0005515	molecular_function	protein binding
E	0005777	cellular_component	peroxisome
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0006531	biological_process	aspartate metabolic process
E	0008445	molecular_function	D-aspartate oxidase activity
E	0010646	biological_process	regulation of cell communication
E	0019478	biological_process	D-amino acid catabolic process
E	0047821	molecular_function	D-glutamate oxidase activity
E	0050877	biological_process	nervous system process
E	0071949	molecular_function	FAD binding
F	0003884	molecular_function	D-amino-acid oxidase activity
F	0005515	molecular_function	protein binding
F	0005777	cellular_component	peroxisome
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0006531	biological_process	aspartate metabolic process
F	0008445	molecular_function	D-aspartate oxidase activity
F	0010646	biological_process	regulation of cell communication
F	0019478	biological_process	D-amino acid catabolic process
F	0047821	molecular_function	D-glutamate oxidase activity
F	0050877	biological_process	nervous system process
F	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue FAD A 401

Chain	Residue
A	GLY10
A	THR43
A	SER44
A	ALA47
A	ALA48
A	GLY49
A	MET50
A	ILE166
A	CYS182
A	SER183
A	GLY184
A	ALA11
A	GLY186
A	LEU190
A	GLY276
A	ARG278
A	PRO279
A	GLY307
A	SER308
A	GLY309
A	GLY310
A	ILE311
A	GLY12
A	SER312
A	GOL402
A	VAL13
A	VAL14
A	SER35
A	ASP36
A	LYS37
A	THR42

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 402

Chain	Residue
A	HIS54
A	ARG216
A	TYR225
A	ARG237
A	ARG278
A	SER308
A	FAD401

site_id	AC3
Number of Residues	6
Details	binding site for residue TRS A 403

Chain	Residue
A	PRO209
A	VAL211
A	GLU212
B	PRO209
B	VAL211
B	GLU212

site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 A 404

Chain	Residue
A	SER93
A	ARG117
B	ARG117

site_id	AC5
Number of Residues	31
Details	binding site for residue FAD B 401

Chain	Residue
B	GLY10
B	GLY12
B	VAL13
B	VAL14
B	SER35
B	ASP36
B	LYS37
B	THR42
B	THR43
B	SER44
B	ALA47
B	ALA48
B	MET50
B	ARG164
B	ARG165
B	ILE166
B	SER183
B	GLY184
B	GLY186
B	LEU190
B	GLY201
B	TYR225
B	GLY276
B	LEU277
B	ARG278
B	GLY307
B	SER308
B	GLY310
B	ILE311
B	SER312
B	GOL402

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL B 402

Chain	Residue
B	HIS54
B	TYR225
B	ARG237
B	ARG278
B	FAD401

site_id	AC7
Number of Residues	27
Details	binding site for residue FAD C 401

Chain	Residue
C	GLY184
C	GLY186
C	LEU190
C	ARG278
C	GLY307
C	SER308
C	GLY309
C	GLY310
C	ILE311
C	SER312
C	GOL403
C	GLY10
C	ALA11
C	GLY12
C	VAL13
C	VAL14
C	SER35
C	ASP36
C	LYS37
C	THR42
C	SER44
C	ALA47
C	ALA48
C	MET50
C	ARG165
C	ILE166
C	SER183

site_id	AC8
Number of Residues	5
Details	binding site for residue TRS C 402

Chain	Residue
C	PRO209
C	VAL211
C	GLU212
D	GLU212
D	GLY227

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL C 403

Chain	Residue
C	ARG216
C	GLY220
C	TYR225
C	ARG237
C	ARG278
C	SER308
C	FAD401

site_id	AD1
Number of Residues	27
Details	binding site for residue FAD D 401

Chain	Residue
D	GLY10
D	ALA11
D	GLY12
D	VAL13
D	VAL14
D	SER35
D	ASP36
D	LYS37
D	THR43
D	SER44
D	VAL46
D	ALA47
D	MET50
D	ARG165
D	ILE166
D	SER183
D	GLY186
D	LEU190
D	ARG278
D	HIS306
D	GLY307
D	SER308
D	GLY309
D	GLY310
D	ILE311
D	SER312
D	GOL402

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL D 402

Chain	Residue
D	HIS54
D	ARG216
D	TYR225
D	FAD401

site_id	AD3
Number of Residues	27
Details	binding site for residue FAD E 401

Chain	Residue
E	GLY10
E	ALA11
E	GLY12
E	VAL13
E	VAL14
E	SER35
E	ASP36
E	LYS37
E	THR42
E	THR43
E	SER44
E	ALA47
E	MET50
E	ILE166
E	CYS182
E	SER183
E	GLY186
E	LEU190
E	GLY276
E	ARG278
E	GLY307
E	SER308
E	GLY309
E	GLY310
E	ILE311
E	SER312
E	GOL402

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL E 402

Chain	Residue
E	TYR225
E	ARG278
E	SER308
E	FAD401

site_id	AD5
Number of Residues	27
Details	binding site for residue FAD F 401

Chain	Residue
F	ALA11
F	GLY12
F	VAL13
F	VAL14
F	SER35
F	ASP36
F	LYS37
F	THR42
F	THR43
F	SER44
F	ALA47
F	ALA48
F	MET50
F	ARG164
F	ILE166
F	SER183
F	GLY186
F	LEU190
F	GLY276
F	ARG278
F	HIS306
F	GLY307
F	SER308
F	GLY309
F	GLY310
F	ILE311
F	SER312

site_id	AD6
Number of Residues	5
Details	binding site for residue TRS F 402

Chain	Residue
E	PRO209
E	GLU212
F	PRO209
F	GLY227
F	THR228

site_id	AD7
Number of Residues	6
Details	binding site for residue GOL F 403

Chain	Residue
F	HIS54
F	ARG216
F	GLY220
F	ARG237
F	ARG278
F	SER308

site_id	AD8
Number of Residues	5
Details	binding site for residue PO4 F 404

Chain	Residue
E	ARG117
F	SER93
F	GLY115
F	ARG117
F	THR137

Functional Information from PROSITE/UniProt

site_id	PS00677
Number of Residues	19
Details	DAO D-amino acid oxidases signature. VVHHYGhGSgGisvhwGtA

Chain	Residue	Details
A	VAL300-ALA318

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31914658","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RKF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)