6RJN
Crystal structure of a Fungal Catalase at 2.3 Angstroms
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000302 | biological_process | response to reactive oxygen species |
| A | 0004096 | molecular_function | catalase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005777 | cellular_component | peroxisome |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000302 | biological_process | response to reactive oxygen species |
| B | 0004096 | molecular_function | catalase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005777 | cellular_component | peroxisome |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000302 | biological_process | response to reactive oxygen species |
| C | 0004096 | molecular_function | catalase activity |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005777 | cellular_component | peroxisome |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0042542 | biological_process | response to hydrogen peroxide |
| C | 0042744 | biological_process | hydrogen peroxide catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000302 | biological_process | response to reactive oxygen species |
| D | 0004096 | molecular_function | catalase activity |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005777 | cellular_component | peroxisome |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0020037 | molecular_function | heme binding |
| D | 0042542 | biological_process | response to hydrogen peroxide |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue HEM A 601 |
| Chain | Residue |
| A | ARG63 |
| A | PHE152 |
| A | HIS209 |
| A | LEU290 |
| A | PHE325 |
| A | VAL341 |
| A | SER344 |
| A | ARG345 |
| A | SER348 |
| A | TYR349 |
| A | THR352 |
| A | VAL64 |
| A | HIS353 |
| A | ARG356 |
| A | HOH736 |
| A | HOH742 |
| A | HOH779 |
| D | ASP56 |
| A | VAL65 |
| A | HIS66 |
| A | ARG103 |
| A | GLY122 |
| A | VAL137 |
| A | TYR138 |
| A | ASN139 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue NDP A 602 |
| Chain | Residue |
| A | PRO142 |
| A | HIS185 |
| A | SER192 |
| A | ARG194 |
| A | ASN204 |
| A | TYR206 |
| A | HIS226 |
| A | LYS228 |
| A | TRP294 |
| A | PRO295 |
| A | HIS296 |
| A | GLN441 |
| A | ALA444 |
| A | LEU445 |
| A | VAL448 |
| A | PHE449 |
| A | GLN455 |
| A | HOH724 |
| A | HOH740 |
| A | HOH749 |
| A | HOH758 |
| A | HOH763 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | TRP446 |
| A | LYS447 |
| A | GLU488 |
| A | HOH813 |
| A | HOH904 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | CYS368 |
| A | ASN386 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | GLU22 |
| A | GLN44 |
| B | LYS212 |
| B | TYR214 |
| B | GLU416 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | LYS212 |
| A | TYR214 |
| A | PRO336 |
| A | GLU416 |
| B | GLU22 |
| B | GLN44 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 607 |
| Chain | Residue |
| A | THR375 |
| A | MET378 |
| A | ASN386 |
| A | ASN388 |
| A | HOH741 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 608 |
| Chain | Residue |
| A | ARG147 |
| A | HIS427 |
| A | TRP428 |
| A | GLY429 |
| A | LEU432 |
| A | HOH719 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 609 |
| Chain | Residue |
| A | ARG57 |
| C | ARG57 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 610 |
| Chain | Residue |
| A | GLY454 |
| A | ARG457 |
| C | ARG457 |
| C | GOL605 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue K A 611 |
| Chain | Residue |
| A | PRO142 |
| A | GLY208 |
| A | GLN224 |
| A | LYS292 |
| A | HOH801 |
| A | HOH880 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 612 |
| Chain | Residue |
| A | ASN28 |
| A | ASN34 |
| A | PRO36 |
| A | HOH788 |
| A | HOH917 |
| A | HOH943 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue K B 601 |
| Chain | Residue |
| A | GLN377 |
| A | MET378 |
| B | SER51 |
| B | PHE55 |
| B | HOH832 |
| site_id | AD5 |
| Number of Residues | 25 |
| Details | binding site for residue HEM B 602 |
| Chain | Residue |
| B | ARG63 |
| B | VAL64 |
| B | VAL65 |
| B | HIS66 |
| B | ARG103 |
| B | GLY122 |
| B | SER124 |
| B | TYR138 |
| B | ASN139 |
| B | PHE152 |
| B | HIS209 |
| B | LEU290 |
| B | PHE325 |
| B | VAL341 |
| B | SER344 |
| B | ARG345 |
| B | SER348 |
| B | TYR349 |
| B | THR352 |
| B | HIS353 |
| B | ARG356 |
| B | HOH747 |
| B | HOH767 |
| B | HOH777 |
| C | ASP56 |
| site_id | AD6 |
| Number of Residues | 21 |
| Details | binding site for residue NDP B 603 |
| Chain | Residue |
| B | HIS185 |
| B | ARG194 |
| B | ASN204 |
| B | TYR206 |
| B | HIS226 |
| B | LYS228 |
| B | VAL293 |
| B | TRP294 |
| B | PRO295 |
| B | HIS296 |
| B | GLN441 |
| B | LEU445 |
| B | VAL448 |
| B | PHE449 |
| B | GLN455 |
| B | GOL607 |
| B | HOH707 |
| B | HOH782 |
| B | HOH802 |
| B | HOH839 |
| B | HOH865 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | ARG118 |
| B | ASN238 |
| B | ALA241 |
| B | GLY242 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | ASP169 |
| B | ASN171 |
| B | HOH719 |
| D | GOL606 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | ASP193 |
| B | ASN235 |
| B | ASN237 |
| B | GLU240 |
| B | GLN455 |
| B | HOH862 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 607 |
| Chain | Residue |
| B | PRO295 |
| B | GLN441 |
| B | ALA444 |
| B | NDP603 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 608 |
| Chain | Residue |
| B | GLN279 |
| B | LYS282 |
| B | GLN283 |
| B | ASP298 |
| C | PEG608 |
| C | HOH838 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 609 |
| Chain | Residue |
| B | ARG57 |
| D | ARG57 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 610 |
| Chain | Residue |
| B | GLY454 |
| B | ARG457 |
| D | HOH851 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue K B 611 |
| Chain | Residue |
| B | PRO142 |
| B | GLY208 |
| B | GLN224 |
| B | LYS292 |
| B | HOH750 |
| B | HOH819 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 612 |
| Chain | Residue |
| B | ASN28 |
| B | ASN34 |
| B | PRO36 |
| B | HOH762 |
| B | HOH967 |
| B | HOH994 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue K B 613 |
| Chain | Residue |
| B | SER51 |
| B | HOH959 |
| C | SER150 |
| C | HOH805 |
| site_id | AE8 |
| Number of Residues | 25 |
| Details | binding site for residue HEM C 601 |
| Chain | Residue |
| B | ASP56 |
| C | ARG63 |
| C | VAL64 |
| C | VAL65 |
| C | HIS66 |
| C | ARG103 |
| C | GLY122 |
| C | VAL137 |
| C | TYR138 |
| C | ASN139 |
| C | PHE152 |
| C | HIS209 |
| C | PHE325 |
| C | VAL341 |
| C | SER344 |
| C | ARG345 |
| C | SER348 |
| C | TYR349 |
| C | THR352 |
| C | HIS353 |
| C | ARG356 |
| C | HOH710 |
| C | HOH756 |
| C | HOH771 |
| C | HOH777 |
| site_id | AE9 |
| Number of Residues | 22 |
| Details | binding site for residue NDP C 602 |
| Chain | Residue |
| C | HIS185 |
| C | TYR189 |
| C | SER192 |
| C | ARG194 |
| C | ASN204 |
| C | TYR206 |
| C | HIS226 |
| C | LYS228 |
| C | VAL293 |
| C | TRP294 |
| C | PRO295 |
| C | HIS296 |
| C | GLN441 |
| C | ALA444 |
| C | LEU445 |
| C | VAL448 |
| C | PHE449 |
| C | LYS451 |
| C | GLN455 |
| C | HOH706 |
| C | HOH740 |
| C | HOH867 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 603 |
| Chain | Residue |
| B | ALA245 |
| C | GLY112 |
| C | ALA245 |
| C | PRO249 |
| C | HOH882 |
| site_id | AF2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 604 |
| Chain | Residue |
| C | PRO376 |
| C | THR392 |
| C | PRO393 |
| C | TYR395 |
| C | LYS396 |
| C | SER397 |
| C | CYS400 |
| C | PHE402 |
| D | TRP7 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 605 |
| Chain | Residue |
| A | GLY454 |
| A | CL610 |
| C | ARG457 |
| C | ASN458 |
| C | HIS461 |
| C | GLU496 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 606 |
| Chain | Residue |
| C | ALA117 |
| C | ARG118 |
| C | ASN238 |
| C | ALA241 |
| C | GLY242 |
| C | HOH791 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 607 |
| Chain | Residue |
| C | GLN362 |
| C | CYS368 |
| C | PRO369 |
| C | ASN386 |
| C | HOH701 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 608 |
| Chain | Residue |
| B | LYS282 |
| B | PEG608 |
| C | GLN279 |
| C | GLN283 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue K C 609 |
| Chain | Residue |
| C | PRO142 |
| C | GLY208 |
| C | GLN224 |
| C | LYS292 |
| C | HOH780 |
| C | HOH869 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 610 |
| Chain | Residue |
| C | ASN28 |
| C | ASN34 |
| C | PRO36 |
| C | HOH815 |
| C | HOH935 |
| C | HOH976 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue K C 611 |
| Chain | Residue |
| C | SER51 |
| C | PHE55 |
| C | HOH772 |
| D | GLN377 |
| D | MET378 |
| site_id | AG1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 601 |
| Chain | Residue |
| A | ARG147 |
| A | LYS292 |
| A | TRP428 |
| A | ASP438 |
| A | HOH719 |
| A | HOH786 |
| D | ASN33 |
| D | ALA35 |
| D | PRO36 |
| site_id | AG2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 602 |
| Chain | Residue |
| A | GLY112 |
| A | ALA245 |
| A | PRO249 |
| D | GLY112 |
| D | ALA245 |
| D | PRO249 |
| D | HOH830 |
| D | HOH882 |
| site_id | AG3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 603 |
| Chain | Residue |
| C | HIS54 |
| D | ASN360 |
| D | THR375 |
| D | MET378 |
| D | ASN386 |
| D | ASN388 |
| D | LEU389 |
| D | HOH701 |
| D | HOH816 |
| site_id | AG4 |
| Number of Residues | 24 |
| Details | binding site for residue HEM D 604 |
| Chain | Residue |
| A | ASP56 |
| D | ARG63 |
| D | VAL64 |
| D | VAL65 |
| D | HIS66 |
| D | ARG103 |
| D | GLY122 |
| D | TYR138 |
| D | ASN139 |
| D | PHE152 |
| D | SER207 |
| D | HIS209 |
| D | PHE325 |
| D | VAL341 |
| D | SER344 |
| D | ARG345 |
| D | SER348 |
| D | TYR349 |
| D | THR352 |
| D | HIS353 |
| D | ARG356 |
| D | HOH721 |
| D | HOH744 |
| D | HOH761 |
| site_id | AG5 |
| Number of Residues | 24 |
| Details | binding site for residue NDP D 605 |
| Chain | Residue |
| D | PRO142 |
| D | HIS185 |
| D | SER192 |
| D | ARG194 |
| D | ASN204 |
| D | TYR206 |
| D | HIS226 |
| D | LYS228 |
| D | VAL293 |
| D | TRP294 |
| D | PRO295 |
| D | HIS296 |
| D | GLN441 |
| D | ALA444 |
| D | LEU445 |
| D | VAL448 |
| D | PHE449 |
| D | LYS451 |
| D | GLN455 |
| D | HOH710 |
| D | HOH723 |
| D | HOH802 |
| D | HOH880 |
| D | HOH888 |
| site_id | AG6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 606 |
| Chain | Residue |
| B | GOL605 |
| D | PHE399 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue K D 608 |
| Chain | Residue |
| D | PRO142 |
| D | GLY208 |
| D | GLN224 |
| D | LYS292 |
| D | HOH791 |
| D | HOH834 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue NA D 609 |
| Chain | Residue |
| D | ASN28 |
| D | ASN34 |
| D | ALA35 |
| D | PRO36 |
| D | HOH750 |
| D | HOH954 |
| D | HOH961 |
Functional Information from PROSITE/UniProt
