6RH7

Revisiting pH-gated conformational switch. Complex HK853 mutant H260A -RR468 mutant D53A pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0007165	biological_process	signal transduction
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0007165	biological_process	signal transduction
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0000160	biological_process	phosphorelay signal transduction system
C	0005515	molecular_function	protein binding
C	0046872	molecular_function	metal ion binding
D	0000160	biological_process	phosphorelay signal transduction system
D	0005515	molecular_function	protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue ADP A 501

Chain	Residue
A	ASN376
A	VAL431
A	GLY441
A	THR442
A	GLY443
A	GLY445
A	LEU446
A	HOH622
A	HOH624
A	HOH633
A	HOH641
A	ASN380
A	HOH648
A	HOH675
A	HOH679
A	LYS383
A	TYR384
A	ASP411
A	ILE416
A	ILE424
A	TYR429
A	ARG430

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 502

Chain	Residue
A	ASN300
A	HIS301
A	ASN304
A	HOH601
A	HOH604
A	HOH611
A	HOH638

---

site_id	AC3
Number of Residues	22
Details	binding site for residue ADP B 501

Chain	Residue
B	ASN376
B	ASN380
B	LYS383
B	TYR384
B	ASP411
B	ILE416
B	ILE424
B	TYR429
B	ARG430
B	VAL431
B	GLY441
B	THR442
B	GLY443
B	GLY445
B	LEU446
B	HOH612
B	HOH620
B	HOH626
B	HOH629
B	HOH635
B	HOH656
B	HOH663

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 502

Chain	Residue
B	ASN300
B	HIS301
B	ASN304
B	HOH601

---

site_id	AC5
Number of Residues	1
Details	binding site for residue SO4 B 503

Chain	Residue
B	GLN427

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 C 201

Chain	Residue
C	ALA53
C	ILE54
C	MET55
C	THR83
C	ALA84
C	LYS105
C	HOH301

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 C 202

Chain	Residue
C	SER11
C	ALA12
C	VAL13
C	HOH303
C	HOH306

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 C 203

Chain	Residue
C	VAL102
C	MET103
C	ARG104
C	HOH302
C	HOH304
C	HOH334

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 C 204

Chain	Residue
A	GLU400
A	LYS401
A	ASP402
C	LYS85
C	HOH340

---

site_id	AD1
Number of Residues	6
Details	binding site for residue SO4 D 201

Chain	Residue
D	ALA53
D	ILE54
D	MET55
D	THR83
D	ALA84
D	LYS105

---

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 D 202

Chain	Residue
D	ASP10
D	SER11
D	ALA12
D	VAL13
D	HOH307
D	HOH334
D	HOH340

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 D 203

Chain	Residue
D	ARG104
D	HOH301

---

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 D 204

Chain	Residue
B	GLU400
B	LYS401
B	ASP402
D	LYS85

---