6RH2

Revisiting pH-gated conformational switch. Complex HK853-RR468 D53A pH 5.3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0007165	biological_process	signal transduction
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0007165	biological_process	signal transduction
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0000160	biological_process	phosphorelay signal transduction system
C	0005515	molecular_function	protein binding
C	0046872	molecular_function	metal ion binding
D	0000160	biological_process	phosphorelay signal transduction system
D	0005515	molecular_function	protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue ADP A 501

Chain	Residue
A	ASN376
A	VAL431
A	GLY441
A	THR442
A	GLY443
A	GLY445
A	LEU446
A	SER470
A	HOH609
A	HOH616
A	HOH618
A	ASN380
A	HOH620
A	HOH622
A	HOH651
A	HOH658
A	HOH660
A	LYS383
A	TYR384
A	ASP411
A	ILE416
A	ILE424
A	TYR429
A	ARG430

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 502

Chain	Residue
A	LYS270
A	GLU274
B	ASN300
C	SER108
C	GLN111

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 503

Chain	Residue
A	ARG314
A	ARG317
B	HIS260
D	LYS85
D	SO4204

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 504

Chain	Residue
A	HIS260
A	LYS401
B	ARG314
B	ARG317
C	LYS85
C	SO4204

---

site_id	AC5
Number of Residues	22
Details	binding site for residue ADP B 501

Chain	Residue
B	ASN376
B	ASN380
B	LYS383
B	TYR384
B	ASP411
B	ILE416
B	ILE424
B	TYR429
B	ARG430
B	VAL431
B	GLY441
B	THR442
B	GLY443
B	GLY445
B	LEU446
B	SER470
B	HOH608
B	HOH611
B	HOH615
B	HOH620
B	HOH621
B	HOH662

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 B 502

Chain	Residue
A	ASN300
B	LYS270
B	GLU274
B	HOH624
D	SER108
D	GLN111
D	HOH302

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 C 201

Chain	Residue
C	ALA53
C	ILE54
C	MET55
C	THR83
C	ALA84
C	LYS105
C	HOH333

---

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 C 202

Chain	Residue
A	SER346
C	ASP10
C	SER11
C	ALA12
C	VAL13
C	HOH318
C	HOH319

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 C 203

Chain	Residue
C	MET103
C	ARG104
C	HOH306

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 C 204

Chain	Residue
A	LYS401
A	ASP402
A	SO4504
C	LYS85

---

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 D 201

Chain	Residue
D	ALA53
D	ILE54
D	MET55
D	THR83
D	ALA84
D	LYS105
D	HOH325
D	HOH331

---

site_id	AD3
Number of Residues	8
Details	binding site for residue SO4 D 202

Chain	Residue
D	ASP10
D	SER11
D	ALA12
D	VAL13
D	HOH311
D	HOH313
D	HOH327
B	SER346

---

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 D 203

Chain	Residue
D	VAL102
D	MET103
D	ARG104
D	HOH307

---

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 D 204

Chain	Residue
A	SO4503
B	GLU400
B	LYS401
B	ASP402
D	LYS85
D	HOH310

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