6RGY

Revisiting pH-gated conformational switch. Complex HK853-RR468 pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0007165	biological_process	signal transduction
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0007165	biological_process	signal transduction
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0000160	biological_process	phosphorelay signal transduction system
C	0005515	molecular_function	protein binding
C	0046872	molecular_function	metal ion binding
D	0000160	biological_process	phosphorelay signal transduction system
D	0005515	molecular_function	protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue ADP A 501

Chain	Residue
A	ASN376
A	VAL431
A	GLY441
A	THR442
A	GLY443
A	GLY445
A	LEU446
A	HOH610
A	HOH617
A	HOH618
A	HOH620
A	ASN380
A	HOH628
A	HOH634
A	HOH648
A	LYS383
A	TYR384
A	ASP411
A	ILE416
A	ILE424
A	TYR429
A	ARG430

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 502

Chain	Residue
A	HIS260
B	LEU310
C	ALA84
C	LYS85
C	GLY86
C	ASP90

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 503

Chain	Residue
A	LYS270
A	GLU274
B	ASN300
C	SER108
C	GLN111

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 504

Chain	Residue
A	LYS245
A	ARG246
A	GLU426
A	GLN427
A	HOH611
A	HOH622

---

site_id	AC5
Number of Residues	24
Details	binding site for residue ADP B 501

Chain	Residue
B	ASN376
B	ASN380
B	LYS383
B	TYR384
B	ASP411
B	GLY415
B	ILE416
B	ILE424
B	TYR429
B	ARG430
B	VAL431
B	GLY441
B	THR442
B	GLY443
B	LEU446
B	PHE472
B	HOH610
B	HOH611
B	HOH612
B	HOH617
B	HOH629
B	HOH635
B	HOH642
B	HOH643

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 B 502

Chain	Residue
A	ASN300
B	LYS270
B	GLU274
D	SER108

---

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 B 503

Chain	Residue
B	ARG314
B	SER319
C	GLY87
C	GLU89
C	ASP90
C	HOH316

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 B 504

Chain	Residue
B	LYS245
B	GLN427
B	HOH608

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MG C 201

Chain	Residue
C	ASP10
C	BFD53
C	MET55
C	HOH311
C	HOH327

---

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 C 202

Chain	Residue
C	SER11
C	ALA12
C	VAL13
C	HOH301
C	HOH304
C	HOH325
C	HOH326

---

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 C 203

Chain	Residue
C	PHE45
C	THR46

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 C 204

Chain	Residue
C	VAL102
C	MET103
C	ARG104
C	HOH303

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MG D 201

Chain	Residue
D	HOH327
D	ASP9
D	ASP10
D	BFD53
D	MET55
D	HOH319

---

site_id	AD5
Number of Residues	8
Details	binding site for residue SO4 D 202

Chain	Residue
A	ARG314
B	HIS260
D	LYS85
D	GLY86
D	GLY87
D	ASP90
D	CIT206
D	HOH324

---

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 D 203

Chain	Residue
D	VAL102
D	MET103
D	ARG104
D	HOH302

---

site_id	AD7
Number of Residues	6
Details	binding site for residue SO4 D 204

Chain	Residue
D	SER11
D	ALA12
D	VAL13
D	HOH320
D	HOH330
D	HOH333

---

site_id	AD8
Number of Residues	6
Details	binding site for residue SO4 D 205

Chain	Residue
A	ARG314
A	SER319
D	GLY87
D	GLU89
D	ASP90
D	HOH323

---

site_id	AD9
Number of Residues	10
Details	binding site for residue CIT D 206

Chain	Residue
B	HIS260
B	GLU400
B	LYS401
B	ASP402
B	GLY403
D	LYS85
D	SO4202
D	HOH301
D	HOH315
D	HOH317

---