Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6REY

Human 20S-PA200 Proteasome Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0003723	molecular_function	RNA binding
A	0004175	molecular_function	endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0005840	cellular_component	ribosome
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016363	cellular_component	nuclear matrix
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030016	cellular_component	myofibril
A	0030017	cellular_component	sarcomere
A	0035639	molecular_function	purine ribonucleoside triphosphate binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0050727	biological_process	regulation of inflammatory response
A	0051059	molecular_function	NF-kappaB binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0070062	cellular_component	extracellular exosome
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0009615	biological_process	response to virus
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034774	cellular_component	secretory granule lumen
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen
c	0000502	cellular_component	proteasome complex
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006281	biological_process	DNA repair
c	0006974	biological_process	DNA damage response
c	0007283	biological_process	spermatogenesis
c	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
c	0016504	molecular_function	peptidase activator activity
c	0016607	cellular_component	nuclear speck
c	0030154	biological_process	cell differentiation
c	0035092	biological_process	sperm DNA condensation
c	0070577	molecular_function	lysine-acetylated histone binding
c	0070628	molecular_function	proteasome binding
c	1990111	cellular_component	spermatoproteasome complex
C	0000502	cellular_component	proteasome complex
C	0000932	cellular_component	P-body
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
d	0000502	cellular_component	proteasome complex
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006281	biological_process	DNA repair
d	0006974	biological_process	DNA damage response
d	0007283	biological_process	spermatogenesis
d	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
d	0016504	molecular_function	peptidase activator activity
d	0016607	cellular_component	nuclear speck
d	0030154	biological_process	cell differentiation
d	0035092	biological_process	sperm DNA condensation
d	0070577	molecular_function	lysine-acetylated histone binding
d	0070628	molecular_function	proteasome binding
d	1990111	cellular_component	spermatoproteasome complex
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0098794	cellular_component	postsynapse
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034774	cellular_component	secretory granule lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000502	cellular_component	proteasome complex
F	0001530	molecular_function	lipopolysaccharide binding
F	0002376	biological_process	immune system process
F	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045202	cellular_component	synapse
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0052548	biological_process	regulation of endopeptidase activity
G	0070062	cellular_component	extracellular exosome
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005839	cellular_component	proteasome core complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0010243	biological_process	response to organonitrogen compound
K	0010498	biological_process	proteasomal protein catabolic process
K	0014070	biological_process	response to organic cyclic compound
K	0016020	cellular_component	membrane
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0070062	cellular_component	extracellular exosome
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0003723	molecular_function	RNA binding
O	0004175	molecular_function	endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0005840	cellular_component	ribosome
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0016363	cellular_component	nuclear matrix
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030016	cellular_component	myofibril
O	0030017	cellular_component	sarcomere
O	0035639	molecular_function	purine ribonucleoside triphosphate binding
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0050727	biological_process	regulation of inflammatory response
O	0051059	molecular_function	NF-kappaB binding
O	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0070062	cellular_component	extracellular exosome
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0009615	biological_process	response to virus
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0034774	cellular_component	secretory granule lumen
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	1904813	cellular_component	ficolin-1-rich granule lumen
Q	0000502	cellular_component	proteasome complex
Q	0000932	cellular_component	P-body
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043231	cellular_component	intracellular membrane-bounded organelle
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0042802	molecular_function	identical protein binding
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	0098794	cellular_component	postsynapse
S	0000502	cellular_component	proteasome complex
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0034774	cellular_component	secretory granule lumen
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	1904813	cellular_component	ficolin-1-rich granule lumen
T	0000502	cellular_component	proteasome complex
T	0001530	molecular_function	lipopolysaccharide binding
T	0002376	biological_process	immune system process
T	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005813	cellular_component	centrosome
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0045202	cellular_component	synapse
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0052548	biological_process	regulation of endopeptidase activity
U	0070062	cellular_component	extracellular exosome
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005839	cellular_component	proteasome core complex
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
Y	0000502	cellular_component	proteasome complex
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0010243	biological_process	response to organonitrogen compound
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0014070	biological_process	response to organic cyclic compound
Y	0016020	cellular_component	membrane
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0070062	cellular_component	extracellular exosome
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue IHP c 1901

Chain	Residue
c	LYS156
c	ARG1388
c	LYS1391
c	HIS1392
c	SER1434
c	ARG1435
c	LYS1213
c	LYS1216
c	HIS1219
c	LYS1221
c	LYS1271
c	TYR1286
c	LYS1346
c	ARG1350

site_id	AC2
Number of Residues	7
Details	binding site for residue K0W c 1902

Chain	Residue
c	TYR34
c	LYS128
c	LYS129
c	TRP915
c	LYS922
c	LYS932
c	ARG943

site_id	AC3
Number of Residues	14
Details	binding site for residue IHP d 1901

Chain	Residue
d	LYS156
d	LYS1213
d	LYS1216
d	HIS1219
d	LYS1221
d	LYS1271
d	TYR1286
d	LYS1346
d	ARG1350
d	ARG1388
d	LYS1391
d	HIS1392
d	SER1434
d	ARG1435

site_id	AC4
Number of Residues	7
Details	binding site for residue K0W d 1902

Chain	Residue
d	TYR34
d	LYS128
d	LYS129
d	TRP915
d	LYS922
d	LYS932
d	ARG943

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdndvTvWSPqGRihQIEYAmeA

Chain	Residue	Details
F	TYR6-ALA28
C	TYR5-ALA27
A	PHE9-ALA31
B	TYR5-ALA27
E	TYR8-ALA30
D	TYR3-ALA25
G	TYR7-ALA29

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGVkFegGVVIAADmlgsygslarfrnis.RimrvnnstmlgasGdyAD

Chain	Residue	Details
b	LEU12-ASP59
I	ALA4-ASP51
C	LEU35-ASP82
a	LEU13-ASP60
H	MET4-ASP51
L	LEU4-ASP51
J	MET11-ASP58
K	ILE5-ASP52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
c	SER1121
d	SER1121
M	SER134
a	SER34
a	SER40
a	SER134

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
c	SER1614
c	SER1746
d	SER1614
d	SER1746
U	LYS205
U	LYS229

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
M	LYS176
a	LYS176
Q	LYS127
Q	LYS176
P	SER13
P	SER15

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
M	SER30
M	SER181
a	SER30
a	SER181

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
F	LYS115
S	SER63
F	LYS208
T	LYS115
T	LYS208

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
E	SER198
S	SER198

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P17220

Chain	Residue	Details
B	TYR120
P	TYR120

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)