6RAW

D. melanogaster CMG-DNA, State 1A

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005694	cellular_component	chromosome
2	0006260	biological_process	DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006279	biological_process	premeiotic DNA replication
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0030261	biological_process	chromosome condensation
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0046872	molecular_function	metal ion binding
2	0051301	biological_process	cell division
2	0071162	cellular_component	CMG complex
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005694	cellular_component	chromosome
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006279	biological_process	premeiotic DNA replication
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0042555	cellular_component	MCM complex
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0006260	biological_process	DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006279	biological_process	premeiotic DNA replication
4	0007052	biological_process	mitotic spindle organization
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0042555	cellular_component	MCM complex
4	0043138	molecular_function	3'-5' DNA helicase activity
4	0071162	cellular_component	CMG complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000712	biological_process	resolution of meiotic recombination intermediates
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005829	cellular_component	cytosol
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006279	biological_process	premeiotic DNA replication
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030261	biological_process	chromosome condensation
5	0042023	biological_process	DNA endoreduplication
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0051321	biological_process	meiotic cell cycle
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0006260	biological_process	DNA replication
6	0006270	biological_process	DNA replication initiation
6	0006279	biological_process	premeiotic DNA replication
6	0007307	biological_process	eggshell chorion gene amplification
6	0008270	molecular_function	zinc ion binding
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0042555	cellular_component	MCM complex
6	0043138	molecular_function	3'-5' DNA helicase activity
6	0046872	molecular_function	metal ion binding
6	0051301	biological_process	cell division
6	0071162	cellular_component	CMG complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006279	biological_process	premeiotic DNA replication
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0042555	cellular_component	MCM complex
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0071162	cellular_component	CMG complex
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0003682	molecular_function	chromatin binding
A	0003688	molecular_function	DNA replication origin binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006270	biological_process	DNA replication initiation
A	0030261	biological_process	chromosome condensation
A	0031261	cellular_component	DNA replication preinitiation complex
A	0051301	biological_process	cell division
A	0071162	cellular_component	CMG complex
A	1902977	biological_process	mitotic DNA replication preinitiation complex assembly
H	0000811	cellular_component	GINS complex
H	0005634	cellular_component	nucleus
H	0006260	biological_process	DNA replication
H	0006270	biological_process	DNA replication initiation
H	0071162	cellular_component	CMG complex
H	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
L	0000727	biological_process	double-strand break repair via break-induced replication
L	0000811	cellular_component	GINS complex
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006260	biological_process	DNA replication
L	0006270	biological_process	DNA replication initiation
L	0006271	biological_process	DNA strand elongation involved in DNA replication
L	0030261	biological_process	chromosome condensation
L	0032784	biological_process	regulation of DNA-templated transcription elongation
L	0071162	cellular_component	CMG complex
M	0000811	cellular_component	GINS complex
M	0005634	cellular_component	nucleus
M	0006260	biological_process	DNA replication
M	0006270	biological_process	DNA replication initiation
M	0071162	cellular_component	CMG complex
N	0000278	biological_process	mitotic cell cycle
N	0000727	biological_process	double-strand break repair via break-induced replication
N	0000811	cellular_component	GINS complex
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0006260	biological_process	DNA replication
N	0006261	biological_process	DNA-templated DNA replication
N	0006270	biological_process	DNA replication initiation
N	0071162	cellular_component	CMG complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue ATP 2 901

Chain	Residue
2	ILE470
6	GLU470
6	VAL610
6	ARG611
6	GLU614
2	GLY511
2	THR512
2	ALA513
2	LYS514
2	SER515
2	GLN516
2	LEU660
6	ARG379

---

site_id	AC2
Number of Residues	13
Details	binding site for residue ATP 2 902

Chain	Residue
2	GLN591
2	ARG641
2	ARG742
5	ILE340
5	PRO380
5	THR382
5	ALA383
5	LYS384
5	SER385
5	GLN386
5	ASN486
5	ILE533
5	HIS537

---

site_id	AC3
Number of Residues	11
Details	binding site for residue ATP 3 901

Chain	Residue
3	ILE302
3	ALA345
3	LYS346
3	SER347
3	GLU405
3	ASN448
5	LEU366
5	GLU460
5	ARG510
5	VAL609
5	ARG610

---

site_id	AC4
Number of Residues	11
Details	binding site for residue ADP 4 901

Chain	Residue
4	ILE472
4	PRO514
4	GLY515
4	THR516
4	SER517
4	LYS518
4	SER519
4	GLN520
4	GLU577
7	ALA603
7	ARG604

---

site_id	AC5
Number of Residues	8
Details	binding site for residue ADP 6 901

Chain	Residue
4	ARG645
6	ILE350
6	TYR351
6	GLY352
6	SER391
6	ALA393
6	LYS394
6	SER395

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ADP 7 801

Chain	Residue
3	GLU422
3	ARG473
3	ALA609
7	ILE344
7	ALA386
7	LYS387
7	SER388
7	GLN389
7	LEU533
7	ILE537

---

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVCLIDEFD

Chain	Residue	Details
2	GLY567-ASP575
7	GLY440-ASP448
4	GLY571-ASP579
6	GLY447-ASP455
3	GLY399-ASP407
5	GLY437-ASP445

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	622
Details	Domain: {"description":"MCM"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"Arginine finger"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P49736","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P25205","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33992","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	206
Details	Domain: {"description":"MCM","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	27
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q14566","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---