6R8W
Human Cyclophilin D in complex with 2-(exo-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-N-((1R,9R,10S)-10-hydroxy-12-oxa-8-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ylmethyl)-acetamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0006457 | biological_process | protein folding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue O4B A 301 |
| Chain | Residue |
| A | SER101 |
| A | SER101 |
| A | PHE102 |
| A | PHE102 |
| A | LYS190 |
| A | LYS190 |
| A | HOH422 |
| A | HOH422 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue P6G A 302 |
| Chain | Residue |
| A | ILE120 |
| A | TYR121 |
| A | VAL135 |
| A | PRO137 |
| A | HIS173 |
| A | HOH435 |
| A | HOH477 |
| A | HOH521 |
| A | PHE88 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue JVH A 303 |
| Chain | Residue |
| A | ARG97 |
| A | ARG97 |
| A | PHE102 |
| A | GLN105 |
| A | GLY114 |
| A | THR115 |
| A | THR115 |
| A | GLY116 |
| A | SER123 |
| A | ARG124 |
| A | ALA143 |
| A | ASN144 |
| A | THR149 |
| A | GLY151 |
| A | GLN153 |
| A | PHE155 |
| A | HIS168 |
| A | HOH454 |
| A | HOH464 |
| A | HOH481 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIpsFMcQAG |
| Chain | Residue | Details |
| A | TYR90-GLY107 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | LYS67 | |
| Chain | Residue | Details |
| A | LYS86 | |
| A | ILE175 | |
| A | LYS190 | |
| Chain | Residue | Details |
| A | LYS167 | |
| Chain | Residue | Details |
| A | CYS203 | |
