6R8J

Crystal structure of di-phosphorylated human CLK1 in complex with 4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ASP325
A	HOH742
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324

---

site_id	AC2
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AC3
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AC4
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AC5
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AC6
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AC7
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AC8
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AC9
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD1
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD2
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD3
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD4
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD5
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD6
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD7
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

site_id	AD8
Number of Residues	11
Details	binding site for residues JUW A 501 and JUW A 502

Chain	Residue
A	LEU167
A	ALA189
A	LYS191
A	GLU206
A	PHE241
A	GLU242
A	LEU244
A	LEU295
A	VAL324
A	ASP325
A	HOH742

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVVeCidhkaggrh.........VAVK

Chain	Residue	Details
A	LEU167-LYS191

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LtHtDLKpeNILF

Chain	Residue	Details
A	LEU284-PHE296

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP288

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU167
A	LYS191

---